• 00:00 1.
    index 1
  • 00:16 2.
    Introduction
  • 00:19 3.
    Keywords
  • 00:30 4.
    RNA categories
  • 01:08 5.
    Long non-coding RNA functions
  • 01:59 6.
    Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
  • 02:49 7.
    Slide 7
  • 03:03 8.
    Results
  • 03:05 9.
    Targeted inactivation and restoration of Malat1 in mice suggest that Malat1 is a suppressor of breast cancer lung metastasis
  • 04:46 10.
    Slide 10
  • 05:17 11.
    Malat1 suppresses the metastatic ability of breast cancer cells
  • 06:30 12.
    Slide 12
  • 07:06 13.
    MALAT1 interacts with TEAD-family members
  • 09:24 14.
    Conclusion
  • 09:46 15.
    Slide 15
  • 09:57 16.
    In vitro and In vivo
  • 10:14 17.
    Keywords
  • 11:06 18.
    Results
  • 11:08 19.
    Induction of Malat1 levels in cultured BMECs after OGD and mouse cerebral microvessels after focal cerebral ischemia
  • 12:11 20.
    Slide 20
  • 13:37 21.
    Genetic deficiency of Malat1 potentiates ischemic brain injury in mice
  • 14:21 22.
    Inhibitory recovery of sensorimotor functions in Malat1 KO mice after focal cerebral ischemia.
  • 14:49 23.
    Slide 23
  • 16:02 24.
    Slide 24
  • 16:58 25.
    Slide 25
  • 17:42 26.
    Malat1 physically binds to Bim and E-selectin
  • 18:05 27.
    Conclusion
  • 18:22 28.
    Slide 28
  • 18:52 29.
    PI3K/PTEN/Akt pathway
  • 20:26 30.
    Results
  • 20:27 31.
    MALAT1 and Pten were upregulated while miR-320 was suppressed in a mouse model of MI
  • 20:51 32.
    MALAT1 functioned as a ceRNA of miR-320 to regulate Pten in mouse cardiomyocytes
  • 21:19 33.
    Slide 33
  • 23:26 34.
    MALAT1 overexpression promoted myocardial apoptosis via miR-320/Pten axis
  • 23:46 35.
    Slide 35
  • 25:31 36.
    MALAT1 inhibition improved myocardial function through upregulating miR-320 in vivo
  • 26:37 37.
    MALAT1 knockdown alleviated myocardial injury and apoptosis by sponging miR-320 in vivo
  • 26:58 38.
    Slide 38
  • 27:37 39.
    Conclusion
  • 28:21 40.
    THANK YOU
  • 28:33 41.
    Slide 41
  • 28:41 42.
    ** after 20210104_Lab meeting.pptx
  • 28:57 43.
    Slide 35
  • 29:47 44.
    Keywords
  • 29:53 45.
    Results
  • 29:54 46.
    Induction of Malat1 levels in cultured BMECs after OGD and mouse cerebral microvessels after focal cerebral ischemia
  • 29:55 47.
    Slide 20
  • 29:55 48.
    Genetic deficiency of Malat1 potentiates ischemic brain injury in mice
  • 29:56 49.
    Inhibitory recovery of sensorimotor functions in Malat1 KO mice after focal cerebral ischemia.
  • 29:57 50.
    Slide 23
  • 32:31 51.
    Slide 24
  • 32:32 52.
    Slide 25
  • 32:32 53.
    Malat1 physically binds to Bim and E-selectin
  • 32:33 54.
    Conclusion
  • 32:33 55.
    Slide 28
  • 32:34 56.
    PI3K/PTEN/Akt pathway
  • 32:34 57.
    Results
  • 32:34 58.
    MALAT1 and Pten were upregulated while miR-320 was suppressed in a mouse model of MI
  • 32:37 59.
    Long non-coding RNA functions
  • 35:34 60.
    RNA categories
  • 35:45 61.
    Long non-coding RNA functions
  • 35:45 62.
    Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
  • 36:00 63.
    Conclusion
  • 36:41 64.
    Slide 28
  • 36:42 65.
    PI3K/PTEN/Akt pathway
  • 38:52 66.
    Results
  • 38:54 67.
    MALAT1 and Pten were upregulated while miR-320 was suppressed in a mouse model of MI
  • 38:56 68.
    Results
  • 38:56 69.
    PI3K/PTEN/Akt pathway
  • 38:56 70.
    Slide 28
  • 38:57 71.
    Conclusion
  • 38:58 72.
    Malat1 physically binds to Bim and E-selectin
  • 38:58 73.
    Slide 25
  • 38:59 74.
    Slide 24
  • 39:00 75.
    Slide 23
  • 39:00 76.
    Inhibitory recovery of sensorimotor functions in Malat1 KO mice after focal cerebral ischemia.
  • 39:00 77.
    Genetic deficiency of Malat1 potentiates ischemic brain injury in mice
  • 39:01 78.
    Slide 20
  • 39:01 79.
    Induction of Malat1 levels in cultured BMECs after OGD and mouse cerebral microvessels after focal cerebral ischemia
  • 39:02 80.
    Results
  • 39:02 81.
    Keywords
  • 39:03 82.
    In vitro and In vivo
  • 39:03 83.
    Slide 15
  • 39:04 84.
    Conclusion
  • 39:04 85.
    MALAT1 interacts with TEAD-family members
  • 39:04 86.
    Slide 12
  • 39:07 87.
    Malat1 suppresses the metastatic ability of breast cancer cells
  • 39:26 88.
    Slide 10
  • 39:27 89.
    Targeted inactivation and restoration of Malat1 in mice suggest that Malat1 is a suppressor of breast cancer lung metastasis
  • 39:55 90.
    Results
  • 39:56 91.
    Slide 7
  • 39:57 92.
    Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
  • 39:58 93.
    Long non-coding RNA functions
  • 39:58 94.
    RNA categories
  • 39:59 95.
    Keywords
  • 40:00 96.
    Introduction
  • 40:00 97.
    Diverse roles of Long noncoding RNA MALAT1 in several pathologies
  • 40:05 98.
    ** after 20210104_Lab meeting.pptx
  • 41:22 99.
    Slide 47
  • 48:06 100.
    Keywords
  • 48:08 101.
    In vitro and In vivo
  • 48:08 102.
    Slide 15
  • 48:09 103.
    Conclusion
  • 48:09 104.
    MALAT1 interacts with TEAD-family members
  • 48:10 105.
    Conclusion
  • 49:10 106.
    Slide 42
  • 49:12 107.
    Slide 41
  • 49:12 108.
    THANK YOU
  • 49:13 109.
    Conclusion
  • 52:54 110.
    THANK YOU
  • 52:56 111.
    Slide 41
  • 52:59 112.
    ** after 20210104_Lab meeting.pptx
  • Index
  • Notes
  • Comment
  • Fullscreen
20210104-lab meeting_麗宇
Duration: 53:33, Browse: 467, Last Updated: 2021-01-11
    • 00:00 1.
      index 1
    • 00:16 2.
      Introduction
    • 00:19 3.
      Keywords
    • 00:30 4.
      RNA categories
    • 01:08 5.
      Long non-coding RNA functions
    • 01:59 6.
      Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
    • 02:49 7.
      Slide 7
    • 03:03 8.
      Results
    • 03:05 9.
      Targeted inactivation and restoration of Malat1 in mice suggest that Malat1 is a suppressor of breast cancer lung metastasis
    • 04:46 10.
      Slide 10
    • 05:17 11.
      Malat1 suppresses the metastatic ability of breast cancer cells
    • 06:30 12.
      Slide 12
    • 07:06 13.
      MALAT1 interacts with TEAD-family members
    • 09:24 14.
      Conclusion
    • 09:46 15.
      Slide 15
    • 09:57 16.
      In vitro and In vivo
    • 10:14 17.
      Keywords
    • 11:06 18.
      Results
    • 11:08 19.
      Induction of Malat1 levels in cultured BMECs after OGD and mouse cerebral microvessels after focal cerebral ischemia
    • 12:11 20.
      Slide 20
    • 13:37 21.
      Genetic deficiency of Malat1 potentiates ischemic brain injury in mice
    • 14:21 22.
      Inhibitory recovery of sensorimotor functions in Malat1 KO mice after focal cerebral ischemia.
    • 14:49 23.
      Slide 23
    • 16:02 24.
      Slide 24
    • 16:58 25.
      Slide 25
    • 17:42 26.
      Malat1 physically binds to Bim and E-selectin
    • 18:05 27.
      Conclusion
    • 18:22 28.
      Slide 28
    • 18:52 29.
      PI3K/PTEN/Akt pathway
    • 20:26 30.
      Results
    • 20:27 31.
      MALAT1 and Pten were upregulated while miR-320 was suppressed in a mouse model of MI
    • 20:51 32.
      MALAT1 functioned as a ceRNA of miR-320 to regulate Pten in mouse cardiomyocytes
    • 21:19 33.
      Slide 33
    • 23:26 34.
      MALAT1 overexpression promoted myocardial apoptosis via miR-320/Pten axis
    • 23:46 35.
      Slide 35
    • 25:31 36.
      MALAT1 inhibition improved myocardial function through upregulating miR-320 in vivo
    • 26:37 37.
      MALAT1 knockdown alleviated myocardial injury and apoptosis by sponging miR-320 in vivo
    • 26:58 38.
      Slide 38
    • 27:37 39.
      Conclusion
    • 28:21 40.
      THANK YOU
    • 28:33 41.
      Slide 41
    • 28:41 42.
      ** after 20210104_Lab meeting.pptx
    • 28:57 43.
      Slide 35
    • 29:47 44.
      Keywords
    • 29:53 45.
      Results
    • 29:54 46.
      Induction of Malat1 levels in cultured BMECs after OGD and mouse cerebral microvessels after focal cerebral ischemia
    • 29:55 47.
      Slide 20
    • 29:55 48.
      Genetic deficiency of Malat1 potentiates ischemic brain injury in mice
    • 29:56 49.
      Inhibitory recovery of sensorimotor functions in Malat1 KO mice after focal cerebral ischemia.
    • 29:57 50.
      Slide 23
    • 32:31 51.
      Slide 24
    • 32:32 52.
      Slide 25
    • 32:32 53.
      Malat1 physically binds to Bim and E-selectin
    • 32:33 54.
      Conclusion
    • 32:33 55.
      Slide 28
    • 32:34 56.
      PI3K/PTEN/Akt pathway
    • 32:34 57.
      Results
    • 32:34 58.
      MALAT1 and Pten were upregulated while miR-320 was suppressed in a mouse model of MI
    • 32:37 59.
      Long non-coding RNA functions
    • 35:34 60.
      RNA categories
    • 35:45 61.
      Long non-coding RNA functions
    • 35:45 62.
      Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
    • 36:00 63.
      Conclusion
    • 36:41 64.
      Slide 28
    • 36:42 65.
      PI3K/PTEN/Akt pathway
    • 38:52 66.
      Results
    • 38:54 67.
      MALAT1 and Pten were upregulated while miR-320 was suppressed in a mouse model of MI
    • 38:56 68.
      Results
    • 38:56 69.
      PI3K/PTEN/Akt pathway
    • 38:56 70.
      Slide 28
    • 38:57 71.
      Conclusion
    • 38:58 72.
      Malat1 physically binds to Bim and E-selectin
    • 38:58 73.
      Slide 25
    • 38:59 74.
      Slide 24
    • 39:00 75.
      Slide 23
    • 39:00 76.
      Inhibitory recovery of sensorimotor functions in Malat1 KO mice after focal cerebral ischemia.
    • 39:00 77.
      Genetic deficiency of Malat1 potentiates ischemic brain injury in mice
    • 39:01 78.
      Slide 20
    • 39:01 79.
      Induction of Malat1 levels in cultured BMECs after OGD and mouse cerebral microvessels after focal cerebral ischemia
    • 39:02 80.
      Results
    • 39:02 81.
      Keywords
    • 39:03 82.
      In vitro and In vivo
    • 39:03 83.
      Slide 15
    • 39:04 84.
      Conclusion
    • 39:04 85.
      MALAT1 interacts with TEAD-family members
    • 39:04 86.
      Slide 12
    • 39:07 87.
      Malat1 suppresses the metastatic ability of breast cancer cells
    • 39:26 88.
      Slide 10
    • 39:27 89.
      Targeted inactivation and restoration of Malat1 in mice suggest that Malat1 is a suppressor of breast cancer lung metastasis
    • 39:55 90.
      Results
    • 39:56 91.
      Slide 7
    • 39:57 92.
      Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
    • 39:58 93.
      Long non-coding RNA functions
    • 39:58 94.
      RNA categories
    • 39:59 95.
      Keywords
    • 40:00 96.
      Introduction
    • 40:00 97.
      Diverse roles of Long noncoding RNA MALAT1 in several pathologies
    • 40:05 98.
      ** after 20210104_Lab meeting.pptx
    • 41:22 99.
      Slide 47
    • 48:06 100.
      Keywords
    • 48:08 101.
      In vitro and In vivo
    • 48:08 102.
      Slide 15
    • 48:09 103.
      Conclusion
    • 48:09 104.
      MALAT1 interacts with TEAD-family members
    • 48:10 105.
      Conclusion
    • 49:10 106.
      Slide 42
    • 49:12 107.
      Slide 41
    • 49:12 108.
      THANK YOU
    • 49:13 109.
      Conclusion
    • 52:54 110.
      THANK YOU
    • 52:56 111.
      Slide 41
    • 52:59 112.
      ** after 20210104_Lab meeting.pptx
    Location
    Folder name
    2021
    Author
    陳逸安
    Branch
    賴亮全教授
    Created
    2021-01-11 10:50:37
    Last Updated
    2021-01-11 11:42:30
    Duration
    53:33