• 00:16 1.
    index 1
  • 00:02 2.
    Introduction
  • 00:11 3.
    Keywords
  • 00:37 4.
    RNA categories
  • 00:50 5.
    Long non-coding RNA functions
  • 00:50 6.
    Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
  • 00:14 7.
    Slide 7
  • 00:01 8.
    Results
  • 01:40 9.
    Targeted inactivation and restoration of Malat1 in mice suggest that Malat1 is a suppressor of breast cancer lung metastasis
  • 00:31 10.
    Slide 10
  • 01:12 11.
    Malat1 suppresses the metastatic ability of breast cancer cells
  • 00:36 12.
    Slide 12
  • 02:17 13.
    MALAT1 interacts with TEAD-family members
  • 00:21 14.
    Conclusion
  • 00:11 15.
    Slide 15
  • 00:16 16.
    In vitro and In vivo
  • 00:52 17.
    Keywords
  • 00:02 18.
    Results
  • 01:02 19.
    Induction of Malat1 levels in cultured BMECs after OGD and mouse cerebral microvessels after focal cerebral ischemia
  • 01:26 20.
    Slide 20
  • 00:44 21.
    Genetic deficiency of Malat1 potentiates ischemic brain injury in mice
  • 00:28 22.
    Inhibitory recovery of sensorimotor functions in Malat1 KO mice after focal cerebral ischemia.
  • 01:12 23.
    Slide 23
  • 00:56 24.
    Slide 24
  • 00:44 25.
    Slide 25
  • 00:22 26.
    Malat1 physically binds to Bim and E-selectin
  • 00:17 27.
    Conclusion
  • 00:29 28.
    Slide 28
  • 01:33 29.
    PI3K/PTEN/Akt pathway
  • 00:00 30.
    Results
  • 00:24 31.
    MALAT1 and Pten were upregulated while miR-320 was suppressed in a mouse model of MI
  • 00:28 32.
    MALAT1 functioned as a ceRNA of miR-320 to regulate Pten in mouse cardiomyocytes
  • 02:06 33.
    Slide 33
  • 00:19 34.
    MALAT1 overexpression promoted myocardial apoptosis via miR-320/Pten axis
  • 01:44 35.
    Slide 35
  • 01:06 36.
    MALAT1 inhibition improved myocardial function through upregulating miR-320 in vivo
  • 00:20 37.
    MALAT1 knockdown alleviated myocardial injury and apoptosis by sponging miR-320 in vivo
  • 00:38 38.
    Slide 38
  • 00:44 39.
    Conclusion
  • 00:11 40.
    THANK YOU
  • 00:08 41.
    Slide 41
  • 00:15 42.
    ** after 20210104_Lab meeting.pptx
  • 00:49 43.
    Slide 35
  • 00:06 44.
    Keywords
  • 00:00 45.
    Results
  • 00:00 46.
    Induction of Malat1 levels in cultured BMECs after OGD and mouse cerebral microvessels after focal cerebral ischemia
  • 00:00 47.
    Slide 20
  • 00:00 48.
    Genetic deficiency of Malat1 potentiates ischemic brain injury in mice
  • 00:00 49.
    Inhibitory recovery of sensorimotor functions in Malat1 KO mice after focal cerebral ischemia.
  • 02:34 50.
    Slide 23
  • 00:00 51.
    Slide 24
  • 00:00 52.
    Slide 25
  • 00:00 53.
    Malat1 physically binds to Bim and E-selectin
  • 00:00 54.
    Conclusion
  • 00:00 55.
    Slide 28
  • 00:00 56.
    PI3K/PTEN/Akt pathway
  • 00:00 57.
    Results
  • 00:02 58.
    MALAT1 and Pten were upregulated while miR-320 was suppressed in a mouse model of MI
  • 02:57 59.
    Long non-coding RNA functions
  • 00:10 60.
    RNA categories
  • 00:00 61.
    Long non-coding RNA functions
  • 00:14 62.
    Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
  • 00:40 63.
    Conclusion
  • 00:01 64.
    Slide 28
  • 02:10 65.
    PI3K/PTEN/Akt pathway
  • 00:01 66.
    Results
  • 00:02 67.
    MALAT1 and Pten were upregulated while miR-320 was suppressed in a mouse model of MI
  • 00:00 68.
    Results
  • 00:00 69.
    PI3K/PTEN/Akt pathway
  • 00:00 70.
    Slide 28
  • 00:00 71.
    Conclusion
  • 00:00 72.
    Malat1 physically binds to Bim and E-selectin
  • 00:00 73.
    Slide 25
  • 00:00 74.
    Slide 24
  • 00:00 75.
    Slide 23
  • 00:00 76.
    Inhibitory recovery of sensorimotor functions in Malat1 KO mice after focal cerebral ischemia.
  • 00:00 77.
    Genetic deficiency of Malat1 potentiates ischemic brain injury in mice
  • 00:00 78.
    Slide 20
  • 00:00 79.
    Induction of Malat1 levels in cultured BMECs after OGD and mouse cerebral microvessels after focal cerebral ischemia
  • 00:00 80.
    Results
  • 00:00 81.
    Keywords
  • 00:00 82.
    In vitro and In vivo
  • 00:00 83.
    Slide 15
  • 00:00 84.
    Conclusion
  • 00:00 85.
    MALAT1 interacts with TEAD-family members
  • 00:02 86.
    Slide 12
  • 00:18 87.
    Malat1 suppresses the metastatic ability of breast cancer cells
  • 00:01 88.
    Slide 10
  • 00:28 89.
    Targeted inactivation and restoration of Malat1 in mice suggest that Malat1 is a suppressor of breast cancer lung metastasis
  • 00:00 90.
    Results
  • 00:00 91.
    Slide 7
  • 00:00 92.
    Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
  • 00:00 93.
    Long non-coding RNA functions
  • 00:01 94.
    RNA categories
  • 00:00 95.
    Keywords
  • 00:00 96.
    Introduction
  • 00:04 97.
    Diverse roles of Long noncoding RNA MALAT1 in several pathologies
  • 01:16 98.
    ** after 20210104_Lab meeting.pptx
  • 06:44 99.
    Slide 47
  • 00:01 100.
    Keywords
  • 00:00 101.
    In vitro and In vivo
  • 00:00 102.
    Slide 15
  • 00:00 103.
    Conclusion
  • 00:01 104.
    MALAT1 interacts with TEAD-family members
  • 00:59 105.
    Conclusion
  • 00:01 106.
    Slide 42
  • 00:00 107.
    Slide 41
  • 00:00 108.
    THANK YOU
  • 03:41 109.
    Conclusion
  • 00:01 110.
    THANK YOU
  • 00:03 111.
    Slide 41
  • 00:33 112.
    ** after 20210104_Lab meeting.pptx
  • Index
  • Notes
  • Comment
  • Fullscreen
20210104-lab meeting_麗宇
Duration: 53:33, Browse: 344, Last Updated: 2021-01-11
    • 00:16 1.
      index 1
    • 00:02 2.
      Introduction
    • 00:11 3.
      Keywords
    • 00:37 4.
      RNA categories
    • 00:50 5.
      Long non-coding RNA functions
    • 00:50 6.
      Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
    • 00:14 7.
      Slide 7
    • 00:01 8.
      Results
    • 01:40 9.
      Targeted inactivation and restoration of Malat1 in mice suggest that Malat1 is a suppressor of breast cancer lung metastasis
    • 00:31 10.
      Slide 10
    • 01:12 11.
      Malat1 suppresses the metastatic ability of breast cancer cells
    • 00:36 12.
      Slide 12
    • 02:17 13.
      MALAT1 interacts with TEAD-family members
    • 00:21 14.
      Conclusion
    • 00:11 15.
      Slide 15
    • 00:16 16.
      In vitro and In vivo
    • 00:52 17.
      Keywords
    • 00:02 18.
      Results
    • 01:02 19.
      Induction of Malat1 levels in cultured BMECs after OGD and mouse cerebral microvessels after focal cerebral ischemia
    • 01:26 20.
      Slide 20
    • 00:44 21.
      Genetic deficiency of Malat1 potentiates ischemic brain injury in mice
    • 00:28 22.
      Inhibitory recovery of sensorimotor functions in Malat1 KO mice after focal cerebral ischemia.
    • 01:12 23.
      Slide 23
    • 00:56 24.
      Slide 24
    • 00:44 25.
      Slide 25
    • 00:22 26.
      Malat1 physically binds to Bim and E-selectin
    • 00:17 27.
      Conclusion
    • 00:29 28.
      Slide 28
    • 01:33 29.
      PI3K/PTEN/Akt pathway
    • 00:00 30.
      Results
    • 00:24 31.
      MALAT1 and Pten were upregulated while miR-320 was suppressed in a mouse model of MI
    • 00:28 32.
      MALAT1 functioned as a ceRNA of miR-320 to regulate Pten in mouse cardiomyocytes
    • 02:06 33.
      Slide 33
    • 00:19 34.
      MALAT1 overexpression promoted myocardial apoptosis via miR-320/Pten axis
    • 01:44 35.
      Slide 35
    • 01:06 36.
      MALAT1 inhibition improved myocardial function through upregulating miR-320 in vivo
    • 00:20 37.
      MALAT1 knockdown alleviated myocardial injury and apoptosis by sponging miR-320 in vivo
    • 00:38 38.
      Slide 38
    • 00:44 39.
      Conclusion
    • 00:11 40.
      THANK YOU
    • 00:08 41.
      Slide 41
    • 00:15 42.
      ** after 20210104_Lab meeting.pptx
    • 00:49 43.
      Slide 35
    • 00:06 44.
      Keywords
    • 00:00 45.
      Results
    • 00:00 46.
      Induction of Malat1 levels in cultured BMECs after OGD and mouse cerebral microvessels after focal cerebral ischemia
    • 00:00 47.
      Slide 20
    • 00:00 48.
      Genetic deficiency of Malat1 potentiates ischemic brain injury in mice
    • 00:00 49.
      Inhibitory recovery of sensorimotor functions in Malat1 KO mice after focal cerebral ischemia.
    • 02:34 50.
      Slide 23
    • 00:00 51.
      Slide 24
    • 00:00 52.
      Slide 25
    • 00:00 53.
      Malat1 physically binds to Bim and E-selectin
    • 00:00 54.
      Conclusion
    • 00:00 55.
      Slide 28
    • 00:00 56.
      PI3K/PTEN/Akt pathway
    • 00:00 57.
      Results
    • 00:02 58.
      MALAT1 and Pten were upregulated while miR-320 was suppressed in a mouse model of MI
    • 02:57 59.
      Long non-coding RNA functions
    • 00:10 60.
      RNA categories
    • 00:00 61.
      Long non-coding RNA functions
    • 00:14 62.
      Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
    • 00:40 63.
      Conclusion
    • 00:01 64.
      Slide 28
    • 02:10 65.
      PI3K/PTEN/Akt pathway
    • 00:01 66.
      Results
    • 00:02 67.
      MALAT1 and Pten were upregulated while miR-320 was suppressed in a mouse model of MI
    • 00:00 68.
      Results
    • 00:00 69.
      PI3K/PTEN/Akt pathway
    • 00:00 70.
      Slide 28
    • 00:00 71.
      Conclusion
    • 00:00 72.
      Malat1 physically binds to Bim and E-selectin
    • 00:00 73.
      Slide 25
    • 00:00 74.
      Slide 24
    • 00:00 75.
      Slide 23
    • 00:00 76.
      Inhibitory recovery of sensorimotor functions in Malat1 KO mice after focal cerebral ischemia.
    • 00:00 77.
      Genetic deficiency of Malat1 potentiates ischemic brain injury in mice
    • 00:00 78.
      Slide 20
    • 00:00 79.
      Induction of Malat1 levels in cultured BMECs after OGD and mouse cerebral microvessels after focal cerebral ischemia
    • 00:00 80.
      Results
    • 00:00 81.
      Keywords
    • 00:00 82.
      In vitro and In vivo
    • 00:00 83.
      Slide 15
    • 00:00 84.
      Conclusion
    • 00:00 85.
      MALAT1 interacts with TEAD-family members
    • 00:02 86.
      Slide 12
    • 00:18 87.
      Malat1 suppresses the metastatic ability of breast cancer cells
    • 00:01 88.
      Slide 10
    • 00:28 89.
      Targeted inactivation and restoration of Malat1 in mice suggest that Malat1 is a suppressor of breast cancer lung metastasis
    • 00:00 90.
      Results
    • 00:00 91.
      Slide 7
    • 00:00 92.
      Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
    • 00:00 93.
      Long non-coding RNA functions
    • 00:01 94.
      RNA categories
    • 00:00 95.
      Keywords
    • 00:00 96.
      Introduction
    • 00:04 97.
      Diverse roles of Long noncoding RNA MALAT1 in several pathologies
    • 01:16 98.
      ** after 20210104_Lab meeting.pptx
    • 06:44 99.
      Slide 47
    • 00:01 100.
      Keywords
    • 00:00 101.
      In vitro and In vivo
    • 00:00 102.
      Slide 15
    • 00:00 103.
      Conclusion
    • 00:01 104.
      MALAT1 interacts with TEAD-family members
    • 00:59 105.
      Conclusion
    • 00:01 106.
      Slide 42
    • 00:00 107.
      Slide 41
    • 00:00 108.
      THANK YOU
    • 03:41 109.
      Conclusion
    • 00:01 110.
      THANK YOU
    • 00:03 111.
      Slide 41
    • 00:33 112.
      ** after 20210104_Lab meeting.pptx
    Location
    Folder name
    2021
    Author
    陳逸安
    Branch
    賴亮全教授
    Created
    2021-01-11 10:50:37
    Last Updated
    2021-01-11 11:42:30
    Browse
    344
    Duration
    53:33