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00:03
1.
index 1
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00:31
2.
Slide 1
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00:58
3.
ROS
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01:22
4.
The interplay between m6A and oxidative stress
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00:46
5.
Slide 4
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00:47
6.
SUMOylation
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00:01
7.
ROS leads to up-regulation of global mRNA m6A methylation
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00:06
8.
SUMOylation
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04:36
9.
ROS leads to up-regulation of global mRNA m6A methylation
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00:41
10.
ROS leads to up-regulation of global mRNA m6A methylation
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00:05
11.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
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00:01
12.
ROS leads to up-regulation of global mRNA m6A methylation
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01:25
13.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
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03:03
14.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
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03:16
15.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
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06:31
16.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
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01:44
17.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
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00:57
18.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
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02:10
19.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
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03:45
20.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
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02:21
21.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
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07:16
22.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
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02:39
23.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
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02:53
24.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
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02:04
25.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
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05:50
26.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
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01:40
27.
Slide 22
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00:00
28.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
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00:00
29.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
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00:00
30.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
-
00:00
31.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
-
00:00
32.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
-
00:00
33.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
-
00:00
34.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
-
00:00
35.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
-
00:00
36.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
-
00:00
37.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
-
00:00
38.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
-
00:00
39.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
-
00:00
40.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
-
00:00
41.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
-
00:00
42.
ROS leads to up-regulation of global mRNA m6A methylation
-
00:00
43.
ROS leads to up-regulation of global mRNA m6A methylation
-
00:00
44.
SUMOylation
-
00:00
45.
Slide 4
-
00:00
46.
SUMOylation
-
00:01
47.
ROS leads to up-regulation of global mRNA m6A methylation
-
00:39
48.
ROS leads to up-regulation of global mRNA m6A methylation
-
00:00
49.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
-
00:00
50.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
-
00:00
51.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
-
00:00
52.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
-
00:00
53.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
-
00:00
54.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
-
00:00
55.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
-
00:00
56.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
-
00:00
57.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
-
00:01
58.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
-
00:01
59.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
-
00:01
60.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
-
00:30
61.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
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00:22
62.
20230206 lab meeting_照穎.pptx