20230206 lab meeting_照穎 (no sound)

Index

00:03 1.
index 1
00:31 2.
Slide 1
00:58 3.
ROS
01:22 4.
The interplay between m6A and oxidative stress
00:46 5.
Slide 4
00:47 6.
SUMOylation
00:01 7.
ROS leads to up-regulation of global mRNA m6A methylation
00:06 8.
SUMOylation
04:36 9.
ROS leads to up-regulation of global mRNA m6A methylation
00:41 10.
ROS leads to up-regulation of global mRNA m6A methylation
00:05 11.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
00:01 12.
ROS leads to up-regulation of global mRNA m6A methylation
01:25 13.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
03:03 14.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
03:16 15.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
06:31 16.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
01:44 17.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:57 18.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
02:10 19.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
03:45 20.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
02:21 21.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
07:16 22.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
02:39 23.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
02:53 24.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
02:04 25.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
05:50 26.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
01:40 27.
Slide 22
00:00 28.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
00:00 29.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
00:00 30.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:00 31.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:00 32.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:00 33.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
00:00 34.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
00:00 35.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 36.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 37.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 38.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
00:00 39.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
00:00 40.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
00:00 41.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
00:00 42.
ROS leads to up-regulation of global mRNA m6A methylation
00:00 43.
ROS leads to up-regulation of global mRNA m6A methylation
00:00 44.
SUMOylation
00:00 45.
Slide 4
00:00 46.
SUMOylation
00:01 47.
ROS leads to up-regulation of global mRNA m6A methylation
00:39 48.
ROS leads to up-regulation of global mRNA m6A methylation
00:00 49.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
00:00 50.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
00:00 51.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
00:00 52.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
00:00 53.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 54.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 55.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 56.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
00:00 57.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
00:01 58.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:01 59.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:01 60.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:30 61.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
00:22 62.
20230206 lab meeting_照穎.pptx

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Comment

00:03 1.
index 1
00:31 2.
Slide 1
00:58 3.
ROS
01:22 4.
The interplay between m6A and oxidative stress
00:46 5.
Slide 4
00:47 6.
SUMOylation
00:01 7.
ROS leads to up-regulation of global mRNA m6A methylation
00:06 8.
SUMOylation
04:36 9.
ROS leads to up-regulation of global mRNA m6A methylation
00:41 10.
ROS leads to up-regulation of global mRNA m6A methylation
00:05 11.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
00:01 12.
ROS leads to up-regulation of global mRNA m6A methylation
01:25 13.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
03:03 14.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
03:16 15.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
06:31 16.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
01:44 17.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:57 18.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
02:10 19.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
03:45 20.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
02:21 21.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
07:16 22.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
02:39 23.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
02:53 24.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
02:04 25.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
05:50 26.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
01:40 27.
Slide 22
00:00 28.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
00:00 29.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
00:00 30.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:00 31.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:00 32.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:00 33.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
00:00 34.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
00:00 35.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 36.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 37.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 38.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
00:00 39.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
00:00 40.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
00:00 41.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
00:00 42.
ROS leads to up-regulation of global mRNA m6A methylation
00:00 43.
ROS leads to up-regulation of global mRNA m6A methylation
00:00 44.
SUMOylation
00:00 45.
Slide 4
00:00 46.
SUMOylation
00:01 47.
ROS leads to up-regulation of global mRNA m6A methylation
00:39 48.
ROS leads to up-regulation of global mRNA m6A methylation
00:00 49.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
00:00 50.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
00:00 51.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
00:00 52.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
00:00 53.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 54.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 55.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 56.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
00:00 57.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
00:01 58.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:01 59.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:01 60.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:30 61.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
00:22 62.
20230206 lab meeting_照穎.pptx

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20230206 lab meeting_照穎 (no sound)

Duration: 59:34, Browse: 65, Last Updated: 2023-05-16

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00:03 1.
index 1
00:31 2.
Slide 1
00:58 3.
ROS
01:22 4.
The interplay between m6A and oxidative stress
00:46 5.
Slide 4
00:47 6.
SUMOylation
00:01 7.
ROS leads to up-regulation of global mRNA m6A methylation
00:06 8.
SUMOylation
04:36 9.
ROS leads to up-regulation of global mRNA m6A methylation
00:41 10.
ROS leads to up-regulation of global mRNA m6A methylation
00:05 11.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
00:01 12.
ROS leads to up-regulation of global mRNA m6A methylation
01:25 13.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
03:03 14.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
03:16 15.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
06:31 16.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
01:44 17.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:57 18.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
02:10 19.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
03:45 20.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
02:21 21.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
07:16 22.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
02:39 23.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
02:53 24.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
02:04 25.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
05:50 26.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
01:40 27.
Slide 22
00:00 28.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
00:00 29.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
00:00 30.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:00 31.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:00 32.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:00 33.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
00:00 34.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
00:00 35.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 36.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 37.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 38.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
00:00 39.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
00:00 40.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
00:00 41.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
00:00 42.
ROS leads to up-regulation of global mRNA m6A methylation
00:00 43.
ROS leads to up-regulation of global mRNA m6A methylation
00:00 44.
SUMOylation
00:00 45.
Slide 4
00:00 46.
SUMOylation
00:01 47.
ROS leads to up-regulation of global mRNA m6A methylation
00:39 48.
ROS leads to up-regulation of global mRNA m6A methylation
00:00 49.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
00:00 50.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
00:00 51.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
00:00 52.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
00:00 53.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 54.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 55.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
00:00 56.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
00:00 57.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
00:01 58.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:01 59.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:01 60.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
00:30 61.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
00:22 62.
20230206 lab meeting_照穎.pptx

Location

Folder name

2023

Author

黃照穎

Branch

賴亮全教授

Created

2023-02-06 10:28:01

Last Updated

2023-05-16 16:29:05

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Duration

59:34