20230206 lab meeting_照穎 (no sound)

索引

00:00 1.
index 1
00:03 2.
Slide 1
00:35 3.
ROS
01:33 4.
The interplay between m6A and oxidative stress
02:55 5.
Slide 4
03:42 6.
SUMOylation
04:29 7.
ROS leads to up-regulation of global mRNA m6A methylation
04:31 8.
SUMOylation
04:38 9.
ROS leads to up-regulation of global mRNA m6A methylation
09:14 10.
ROS leads to up-regulation of global mRNA m6A methylation
09:55 11.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
10:00 12.
ROS leads to up-regulation of global mRNA m6A methylation
10:02 13.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
11:28 14.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
14:31 15.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
17:47 16.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
24:19 17.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
26:04 18.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
27:01 19.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
29:12 20.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
32:57 21.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
35:19 22.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
42:35 23.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
45:15 24.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
48:09 25.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
50:13 26.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
56:03 27.
Slide 22
57:44 28.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
57:44 29.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
57:44 30.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
57:45 31.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
57:45 32.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
57:45 33.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
57:46 34.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
57:46 35.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
57:46 36.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
57:47 37.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
57:47 38.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
57:48 39.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
57:48 40.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
57:48 41.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
57:48 42.
ROS leads to up-regulation of global mRNA m6A methylation
57:49 43.
ROS leads to up-regulation of global mRNA m6A methylation
57:49 44.
SUMOylation
57:49 45.
Slide 4
57:50 46.
SUMOylation
57:50 47.
ROS leads to up-regulation of global mRNA m6A methylation
57:52 48.
ROS leads to up-regulation of global mRNA m6A methylation
58:32 49.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
58:32 50.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
58:32 51.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
58:33 52.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
58:33 53.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
58:33 54.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
58:34 55.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
58:34 56.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
58:34 57.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
58:35 58.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
58:37 59.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
58:39 60.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
58:40 61.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
59:11 62.
20230206 lab meeting_照穎.pptx

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討論

00:00 1.
index 1
00:03 2.
Slide 1
00:35 3.
ROS
01:33 4.
The interplay between m6A and oxidative stress
02:55 5.
Slide 4
03:42 6.
SUMOylation
04:29 7.
ROS leads to up-regulation of global mRNA m6A methylation
04:31 8.
SUMOylation
04:38 9.
ROS leads to up-regulation of global mRNA m6A methylation
09:14 10.
ROS leads to up-regulation of global mRNA m6A methylation
09:55 11.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
10:00 12.
ROS leads to up-regulation of global mRNA m6A methylation
10:02 13.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
11:28 14.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
14:31 15.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
17:47 16.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
24:19 17.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
26:04 18.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
27:01 19.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
29:12 20.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
32:57 21.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
35:19 22.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
42:35 23.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
45:15 24.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
48:09 25.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
50:13 26.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
56:03 27.
Slide 22
57:44 28.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
57:44 29.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
57:44 30.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
57:45 31.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
57:45 32.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
57:45 33.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
57:46 34.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
57:46 35.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
57:46 36.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
57:47 37.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
57:47 38.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
57:48 39.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
57:48 40.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
57:48 41.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
57:48 42.
ROS leads to up-regulation of global mRNA m6A methylation
57:49 43.
ROS leads to up-regulation of global mRNA m6A methylation
57:49 44.
SUMOylation
57:49 45.
Slide 4
57:50 46.
SUMOylation
57:50 47.
ROS leads to up-regulation of global mRNA m6A methylation
57:52 48.
ROS leads to up-regulation of global mRNA m6A methylation
58:32 49.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
58:32 50.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
58:32 51.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
58:33 52.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
58:33 53.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
58:33 54.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
58:34 55.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
58:34 56.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
58:34 57.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
58:35 58.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
58:37 59.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
58:39 60.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
58:40 61.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
59:11 62.
20230206 lab meeting_照穎.pptx

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20230206 lab meeting_照穎 (no sound)

長度: 59:34, 瀏覽: 316, 最近修訂: 2023-05-16

00:00 1.
index 1
00:03 2.
Slide 1
00:35 3.
ROS
01:33 4.
The interplay between m6A and oxidative stress
02:55 5.
Slide 4
03:42 6.
SUMOylation
04:29 7.
ROS leads to up-regulation of global mRNA m6A methylation
04:31 8.
SUMOylation
04:38 9.
ROS leads to up-regulation of global mRNA m6A methylation
09:14 10.
ROS leads to up-regulation of global mRNA m6A methylation
09:55 11.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
10:00 12.
ROS leads to up-regulation of global mRNA m6A methylation
10:02 13.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
11:28 14.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
14:31 15.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
17:47 16.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
24:19 17.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
26:04 18.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
27:01 19.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
29:12 20.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
32:57 21.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
35:19 22.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
42:35 23.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
45:15 24.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
48:09 25.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
50:13 26.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
56:03 27.
Slide 22
57:44 28.
ROS stress response occurs in mouse bone marrow progenitor cells in vivo
57:44 29.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
57:44 30.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
57:45 31.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
57:45 32.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
57:45 33.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
57:46 34.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
57:46 35.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
57:46 36.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
57:47 37.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
57:47 38.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
57:48 39.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
57:48 40.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
57:48 41.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
57:48 42.
ROS leads to up-regulation of global mRNA m6A methylation
57:49 43.
ROS leads to up-regulation of global mRNA m6A methylation
57:49 44.
SUMOylation
57:49 45.
Slide 4
57:50 46.
SUMOylation
57:50 47.
ROS leads to up-regulation of global mRNA m6A methylation
57:52 48.
ROS leads to up-regulation of global mRNA m6A methylation
58:32 49.
Reducing the expression of m6A writer partially blocks ROS - induced global increase in mRNA m6A methylation
58:32 50.
ROS promotes mRNA m6A demethylase ALKBH5 SUMOylation
58:32 51.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
58:33 52.
ALKBH5 SUMOylation blocks m6A demethylase activity by inhibition of substrate accessibility
58:33 53.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
58:33 54.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
58:34 55.
SUMOylation-deficient ALKBH5 overexpression blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis
58:34 56.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
58:34 57.
ROS induces ALKBH5 phosphorylation and SUMOylation by activation of ERK/JNK signaling
58:35 58.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
58:37 59.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
58:39 60.
Global gene expression profiling identifies DNA damage repair genes as ALKBH5 downstream targets induced by ROS
58:40 61.
m6A RNA modification enhances expression of FAAP20, ATRX by IGF2BPs-mediated mRNA stabilization
59:11 62.
20230206 lab meeting_照穎.pptx

位置

資料夾名稱

2023

發表人

黃照穎

單位

賴亮全教授

建立

2023-02-06 10:28:01

最近修訂

2023-05-16 16:29:05

長度

59:34