• 00:00 1.
    index 1
  • 00:22 2.
    Gastric cancer (GC)
  • 00:44 3.
    Gastric cancer (GC)
  • 01:06 4.
    Human Genome
  • 01:20 5.
    Circular RNA (CircRNA)
  • 01:42 6.
    Biogenesis of circRNA
  • 02:12 7.
    CircRNA circularization - Alu element
  • 02:48 8.
    CircRNA circularization – RNA Binding Protein (RBP)
  • 03:16 9.
    Functions of circRNA
  • 03:50 10.
    The role of circRNAs in cancer
  • 04:10 11.
    Results
  • 05:09 12.
    Results
  • 05:48 13.
    Aim
  • 06:04 14.
    Results
  • 06:36 15.
    CircPDIA4 promoted migration and metastasis capabilities of gastric cancer cells in vitro and in vivo
  • 07:24 16.
    CircPDIA4 promoted migration and metastasis capabilities of gastric cancer cells in vitro and in vivo
  • 08:20 17.
    Summary
  • 08:35 18.
    Slide 18
  • 08:43 19.
    The RBP QKI induced the formation of circPDIA4 in gastric cancer cells
  • 09:25 20.
    The RBP QKI induced the formation of circPDIA4 in gastric cancer cells
  • 09:46 21.
    The RBP QKI induced the formation of circPDIA4 in gastric cancer cells
  • 10:09 22.
    The RBP QKI induced the formation of circPDIA4 in gastric cancer cells
  • 10:39 23.
    Summary
  • 11:02 24.
    Slide 24
  • 11:07 25.
    CircPDIA4 bound with DHX9 and ERK1/2
  • 12:22 26.
    CircPDIA4 sustained high phosphorylation levels of ERK1/2
  • 13:30 27.
    CircPDIA4 sustained high phosphorylation levels of ERK1/2 through interrupting binding of DUSP6 with ERK1/2
  • 14:30 28.
    CircPDIA4 sustained high phosphorylation levels of ERK1/2 through interrupting binding of DUSP6 with ERK1/2
  • 14:59 29.
    CircPDIA4 sustained high phosphorylation levels of ERK1/2 and reduced the sensitivity of ERKi
  • 15:31 30.
    Summary
  • 15:31 31.
    CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
  • 15:33 32.
    Summary
  • 15:56 33.
    CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
  • 16:59 34.
    CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
  • 17:40 35.
    CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
  • 18:27 36.
    CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
  • 19:02 37.
    Summary
  • 19:28 38.
    Conclusion
  • 19:48 39.
    Conclusion
  • 20:02 40.
    Conclusion
  • 20:18 41.
    Pros :
  • 20:43 42.
    Slide 40
  • 20:46 43.
    Slide 41
  • 20:47 44.
    ** after 20230307 seminar - 複本.pptx
  • Index
  • Notes
  • Comment
  • Fullscreen
20230213 lab meeting_怡君 (no sound)
Duration: 46:59, Browse: 216, Last Updated: 2023-05-16
    • 00:00 1.
      index 1
    • 00:22 2.
      Gastric cancer (GC)
    • 00:44 3.
      Gastric cancer (GC)
    • 01:06 4.
      Human Genome
    • 01:20 5.
      Circular RNA (CircRNA)
    • 01:42 6.
      Biogenesis of circRNA
    • 02:12 7.
      CircRNA circularization - Alu element
    • 02:48 8.
      CircRNA circularization – RNA Binding Protein (RBP)
    • 03:16 9.
      Functions of circRNA
    • 03:50 10.
      The role of circRNAs in cancer
    • 04:10 11.
      Results
    • 05:09 12.
      Results
    • 05:48 13.
      Aim
    • 06:04 14.
      Results
    • 06:36 15.
      CircPDIA4 promoted migration and metastasis capabilities of gastric cancer cells in vitro and in vivo
    • 07:24 16.
      CircPDIA4 promoted migration and metastasis capabilities of gastric cancer cells in vitro and in vivo
    • 08:20 17.
      Summary
    • 08:35 18.
      Slide 18
    • 08:43 19.
      The RBP QKI induced the formation of circPDIA4 in gastric cancer cells
    • 09:25 20.
      The RBP QKI induced the formation of circPDIA4 in gastric cancer cells
    • 09:46 21.
      The RBP QKI induced the formation of circPDIA4 in gastric cancer cells
    • 10:09 22.
      The RBP QKI induced the formation of circPDIA4 in gastric cancer cells
    • 10:39 23.
      Summary
    • 11:02 24.
      Slide 24
    • 11:07 25.
      CircPDIA4 bound with DHX9 and ERK1/2
    • 12:22 26.
      CircPDIA4 sustained high phosphorylation levels of ERK1/2
    • 13:30 27.
      CircPDIA4 sustained high phosphorylation levels of ERK1/2 through interrupting binding of DUSP6 with ERK1/2
    • 14:30 28.
      CircPDIA4 sustained high phosphorylation levels of ERK1/2 through interrupting binding of DUSP6 with ERK1/2
    • 14:59 29.
      CircPDIA4 sustained high phosphorylation levels of ERK1/2 and reduced the sensitivity of ERKi
    • 15:31 30.
      Summary
    • 15:31 31.
      CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
    • 15:33 32.
      Summary
    • 15:56 33.
      CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
    • 16:59 34.
      CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
    • 17:40 35.
      CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
    • 18:27 36.
      CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
    • 19:02 37.
      Summary
    • 19:28 38.
      Conclusion
    • 19:48 39.
      Conclusion
    • 20:02 40.
      Conclusion
    • 20:18 41.
      Pros :
    • 20:43 42.
      Slide 40
    • 20:46 43.
      Slide 41
    • 20:47 44.
      ** after 20230307 seminar - 複本.pptx
    Location
    Folder name
    2023
    Author
    黃照穎
    Branch
    賴亮全教授
    Created
    2023-02-13 10:01:13
    Last Updated
    2023-05-16 16:29:24
    Duration
    46:59