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00:00
1.
index 1
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00:22
2.
Gastric cancer (GC)
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00:44
3.
Gastric cancer (GC)
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01:06
4.
Human Genome
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01:20
5.
Circular RNA (CircRNA)
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01:42
6.
Biogenesis of circRNA
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02:12
7.
CircRNA circularization - Alu element
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02:48
8.
CircRNA circularization – RNA Binding Protein (RBP)
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03:16
9.
Functions of circRNA
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03:50
10.
The role of circRNAs in cancer
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04:10
11.
Results
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05:09
12.
Results
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05:48
13.
Aim
-
06:04
14.
Results
-
06:36
15.
CircPDIA4 promoted migration and metastasis capabilities of gastric cancer cells in vitro and in vivo
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07:24
16.
CircPDIA4 promoted migration and metastasis capabilities of gastric cancer cells in vitro and in vivo
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08:20
17.
Summary
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08:35
18.
Slide 18
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08:43
19.
The RBP QKI induced the formation of circPDIA4 in gastric cancer cells
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09:25
20.
The RBP QKI induced the formation of circPDIA4 in gastric cancer cells
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09:46
21.
The RBP QKI induced the formation of circPDIA4 in gastric cancer cells
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10:09
22.
The RBP QKI induced the formation of circPDIA4 in gastric cancer cells
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10:39
23.
Summary
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11:02
24.
Slide 24
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11:07
25.
CircPDIA4 bound with DHX9 and ERK1/2
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12:22
26.
CircPDIA4 sustained high phosphorylation levels of ERK1/2
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13:30
27.
CircPDIA4 sustained high phosphorylation levels of ERK1/2 through interrupting binding of DUSP6 with ERK1/2
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14:30
28.
CircPDIA4 sustained high phosphorylation levels of ERK1/2 through interrupting binding of DUSP6 with ERK1/2
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14:59
29.
CircPDIA4 sustained high phosphorylation levels of ERK1/2 and reduced the sensitivity of ERKi
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15:31
30.
Summary
-
15:31
31.
CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
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15:33
32.
Summary
-
15:56
33.
CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
-
16:59
34.
CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
-
17:40
35.
CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
-
18:27
36.
CircPDIA4 competitively combined with DHX9 as a decoy to promote oncogenic circRNAs formation
-
19:02
37.
Summary
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19:28
38.
Conclusion
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19:48
39.
Conclusion
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20:02
40.
Conclusion
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20:18
41.
Pros :
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20:43
42.
Slide 40
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20:46
43.
Slide 41
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20:47
44.
** after 20230307 seminar - 複本.pptx