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00:00
1.
index 1
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00:11
2.
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2
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00:17
3.
** after 20230821 rehearsal.pptx
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00:25
4.
index 4
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00:31
5.
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2
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00:32
6.
Chronic obstructive pulmonary disease was ranked as the third leading cause of death
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00:35
7.
** after 20230821 rehearsal.pptx
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00:40
8.
index 8
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01:06
9.
Chronic obstructive pulmonary disease was ranked as the third leading cause of death
-
01:13
10.
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2
-
03:48
11.
Chronic obstructive pulmonary disease was ranked as the third leading cause of death
-
04:50
12.
Classification of severity in COPD
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05:25
13.
Risk factor of COPD
-
05:48
14.
Slide 5
-
06:23
15.
Ferroptosis
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07:14
16.
COPD therapy
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07:55
17.
N6-Methyladenosine (m6A)
-
09:24
18.
circRNA
-
10:26
19.
Whether COPD progression was associated with ferroptosis?Which circRNA could be a biomarker in this mechanism?
-
10:46
20.
Ferroptosis, an iron homeostasis disorder, related to COPD progression.
-
10:53
21.
Whether COPD progression was associated with ferroptosis?Which circRNA could be a biomarker in this mechanism?
-
10:54
22.
Ferroptosis, an iron homeostasis disorder, related to COPD progression.
-
10:56
23.
Whether COPD progression was associated with ferroptosis?Which circRNA could be a biomarker in this mechanism?
-
10:57
24.
circRNA
-
10:57
25.
N6-Methyladenosine (m6A)
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10:58
26.
COPD therapy
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10:58
27.
Ferroptosis
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10:59
28.
Slide 5
-
11:00
29.
Ferroptosis
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11:03
30.
COPD therapy
-
11:05
31.
Ferroptosis
-
11:05
32.
Slide 5
-
11:05
33.
Risk factor of COPD
-
11:06
34.
Classification of severity in COPD
-
11:06
35.
Chronic obstructive pulmonary disease was ranked as the third leading cause of death
-
11:06
36.
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2
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11:13
37.
Iron overload is involved in experimental COPD due to excessive lipid peroxidation.
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11:26
38.
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2
-
11:59
39.
Chronic obstructive pulmonary disease was ranked as the third leading cause of death
-
12:00
40.
Classification of severity in COPD
-
14:20
41.
Risk factor of COPD
-
14:22
42.
Slide 5
-
14:23
43.
Ferroptosis
-
15:01
44.
COPD therapy
-
15:02
45.
N6-Methyladenosine (m6A)
-
15:03
46.
circRNA
-
15:08
47.
N6-Methyladenosine (m6A)
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17:17
48.
circRNA
-
17:19
49.
Whether COPD progression was associated with ferroptosis?Which circRNA could be a biomarker in this mechanism?
-
17:20
50.
Ferroptosis, an iron homeostasis disorder, related to COPD progression.
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18:09
51.
Ferroptosis, an iron homeostasis disorder, related to COPD progression.
-
18:31
52.
Slide 13
-
18:46
53.
Ferroptosis, an iron homeostasis disorder, related to COPD progression.
-
18:46
54.
Ferroptosis, an iron homeostasis disorder, related to COPD progression.
-
19:10
55.
Whether COPD progression was associated with ferroptosis?Which circRNA could be a biomarker in this mechanism?
-
19:10
56.
circRNA
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19:11
57.
N6-Methyladenosine (m6A)
-
19:12
58.
COPD therapy
-
19:13
59.
Ferroptosis
-
19:20
60.
COPD therapy
-
19:20
61.
N6-Methyladenosine (m6A)
-
19:22
62.
circRNA
-
19:25
63.
Whether COPD progression was associated with ferroptosis?Which circRNA could be a biomarker in this mechanism?
-
19:25
64.
Ferroptosis, an iron homeostasis disorder, related to COPD progression.
-
21:23
65.
Ferroptosis, an iron homeostasis disorder, related to COPD progression.
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21:23
66.
Slide 13
-
21:24
67.
circSAV1 was elevated in lung tissue of smokers and COPD smokers, and related to COPD progression.
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21:45
68.
circSAV1 was elevated in lung tissue of smokers and COPD smokers, and related to COPD progression.
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22:43
69.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
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22:47
70.
circSAV1 was elevated in lung tissue of smokers and COPD smokers, and related to COPD progression.
-
23:31
71.
circSAV1 was elevated in lung tissue of smokers and COPD smokers, and related to COPD progression.
-
23:49
72.
circSAV1 was elevated in lung tissue of smokers and COPD smokers, and related to COPD progression.
-
24:11
73.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
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25:04
74.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
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25:32
75.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
-
26:20
76.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
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26:23
77.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
-
26:27
78.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
-
26:28
79.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
-
26:49
80.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
-
26:55
81.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
-
29:00
82.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
-
29:22
83.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
-
30:28
84.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
-
31:13
85.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
-
32:18
86.
In BEAS-2B cells, circSAV1 triggered ferroptosis via IREB2.
-
32:24
87.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
-
32:26
88.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
-
38:39
89.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
-
38:42
90.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
-
39:48
91.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
-
40:12
92.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
-
40:17
93.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
-
45:10
94.
** after 20230821 rehearsal.pptx
-
45:31
95.
EMSA
-
47:38
96.
** after 20230821 rehearsal.pptx
-
47:48
97.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
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57:53
98.
In BEAS-2B cells, circSAV1 triggered ferroptosis via IREB2.
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58:52
99.
In BEAS-2B cells, circSAV1 triggered ferroptosis via IREB2.
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59:15
100.
DFO ameliorated emphysema and airway remodeling through inhibiting ferroptosis in experimental COPD.
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59:18
101.
In BEAS-2B cells, circSAV1 triggered ferroptosis via IREB2.
-
59:30
102.
DFO ameliorated emphysema and airway remodeling through inhibiting ferroptosis in experimental COPD.
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1:00:11
103.
In BEAS-2B cells, circSAV1 triggered ferroptosis via IREB2.
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1:00:14
104.
DFO ameliorated emphysema and airway remodeling through inhibiting ferroptosis in experimental COPD.
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1:01:05
105.
DFO ameliorated emphysema and airway remodeling through inhibiting ferroptosis in experimental COPD.
-
1:02:10
106.
Downregulated circSAV1 reduces emphysema and airway remodeling through inhibiting ferroptosis in experimental COPD.
-
1:02:32
107.
Downregulated circSAV1 reduces emphysema and airway remodeling through inhibiting ferroptosis in experimental COPD.
-
1:02:44
108.
Downregulated circSAV1 reduces emphysema and airway remodeling through inhibiting ferroptosis in experimental COPD.
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1:03:08
109.
Slide 28
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1:04:04
110.
Slide 29
-
1:04:19
111.
Slide 30
-
1:05:03
112.
Slide 29
-
1:05:03
113.
Slide 28
-
1:05:04
114.
Downregulated circSAV1 reduces emphysema and airway remodeling through inhibiting ferroptosis in experimental COPD.
-
1:05:04
115.
Downregulated circSAV1 reduces emphysema and airway remodeling through inhibiting ferroptosis in experimental COPD.
-
1:05:05
116.
Downregulated circSAV1 reduces emphysema and airway remodeling through inhibiting ferroptosis in experimental COPD.
-
1:05:05
117.
DFO ameliorated emphysema and airway remodeling through inhibiting ferroptosis in experimental COPD.
-
1:05:06
118.
DFO ameliorated emphysema and airway remodeling through inhibiting ferroptosis in experimental COPD.
-
1:05:07
119.
In BEAS-2B cells, circSAV1 triggered ferroptosis via IREB2.
-
1:05:07
120.
In BEAS-2B cells, circSAV1 triggered ferroptosis via IREB2.
-
1:05:08
121.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
-
1:05:08
122.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
-
1:05:09
123.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
-
1:05:10
124.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
-
1:05:10
125.
circSAV1 enhanced free iron and triggered ferroptosis in CSE-treated BEAS-2B cells.
-
1:05:11
126.
circSAV1 was elevated in lung tissue of smokers and COPD smokers, and related to COPD progression.
-
1:05:12
127.
circSAV1 was elevated in lung tissue of smokers and COPD smokers, and related to COPD progression.
-
1:05:13
128.
Slide 13
-
1:05:14
129.
Ferroptosis, an iron homeostasis disorder, related to COPD progression.
-
1:05:14
130.
Ferroptosis, an iron homeostasis disorder, related to COPD progression.
-
1:05:15
131.
Whether COPD progression was associated with ferroptosis?Which circRNA could be a biomarker in this mechanism?
-
1:05:15
132.
circRNA
-
1:05:15
133.
N6-Methyladenosine (m6A)
-
1:05:16
134.
COPD therapy
-
1:05:16
135.
Ferroptosis
-
1:05:17
136.
Slide 5
-
1:05:17
137.
Risk factor of COPD
-
1:05:18
138.
Slide 5
-
1:06:09
139.
Ferroptosis
-
1:06:55
140.
Slide 5
-
1:06:56
141.
Risk factor of COPD
-
1:08:58
142.
Slide 5
-
1:08:59
143.
Ferroptosis
-
1:08:59
144.
COPD therapy
-
1:09:00
145.
N6-Methyladenosine (m6A)
-
1:09:01
146.
circRNA
-
1:09:06
147.
** after 20230821 rehearsal.pptx
-
1:09:22
148.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
-
1:10:33
149.
** after 20230821 rehearsal.pptx
-
1:10:42
150.
circSAV1 interacted with YTHDF1 via its m6A motif, which contributed to IREB2 mRNA translation.
-
1:15:23
151.
** after 20230821 rehearsal.pptx