20231030 lab meeting_楷軒 | 賴亮全實驗室

Index

00:00 1.
index 1
00:28 2.
Slide 2
00:29 3.
HBV-related hepatocellular carcinoma
02:15 4.
HBV induces protein O-GlcNAcylation in liver cancer
03:29 5.
Hexosamine Biosynthetic Pathway (O-GlcNAcylation)
05:00 6.
RNA N6-methyladenosine (m6A) Modification
06:18 7.
Slide 7
06:42 8.
Slide 8
07:47 9.
HBV infection enhanced YTHDF2 O-GlcNAcylation in vivo and clinical
07:50 10.
Slide 8
07:58 11.
HBV infection enhanced YTHDF2 O-GlcNAcylation in vivo and clinical
10:31 12.
HBV infection enhanced YTHDF2 O-GlcNAcylation in vitro
12:58 13.
OGT interacted with the N-terminal region of YTHDF2
23:00 14.
Ser263 is the major O-GlcNAcylation site of YTHDF2
29:00 15.
YTHDF2 protein was more stable after HBV infection in HCCKnockdown of OGT greatly shortened YTHDF2 lifespan
34:57 16.
TMG treatment could not restorereducing YTHDF2 half-life by S263A- YTHDF2 mutant
35:39 17.
Slide 15
35:40 18.
TMG treatment could not restorereducing YTHDF2 half-life by S263A- YTHDF2 mutant
38:36 19.
Slide 15
47:39 20.
O-GlcNAcylation of YTHDF2 promotes hepatocellular carcinoma cell proliferation, invasion and migration in vitro
49:57 21.
O-GlcNAcylation of YTHDF2 promotes tumor growth in vivo
50:37 22.
Identification of YTHDF2 targets by RNA-seq, m6A-seq and RIP-seq
58:19 23.
O-GlcNAcylation of YTHDF2 increased MCM2/5 mRNA stability in an m6A-dependent manner
1:06:02 24.
MCM2/5 promotes HCC proliferation by O-GlcNAcylation of YTHDF2
1:08:24 25.
Slide 21
1:10:38 26.
Slide 22
1:11:46 27.
Slide 23
1:12:37 28.
Slide 24
1:12:38 29.
Conclusion
1:13:33 30.
Comments
1:13:37 31.
Conclusion
1:14:02 32.
Comments
1:14:42 33.
Slide 27
1:15:11 34.
** after 20231030 meeting.pptx

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00:00 1.
index 1
00:28 2.
Slide 2
00:29 3.
HBV-related hepatocellular carcinoma
02:15 4.
HBV induces protein O-GlcNAcylation in liver cancer
03:29 5.
Hexosamine Biosynthetic Pathway (O-GlcNAcylation)
05:00 6.
RNA N6-methyladenosine (m6A) Modification
06:18 7.
Slide 7
06:42 8.
Slide 8
07:47 9.
HBV infection enhanced YTHDF2 O-GlcNAcylation in vivo and clinical
07:50 10.
Slide 8
07:58 11.
HBV infection enhanced YTHDF2 O-GlcNAcylation in vivo and clinical
10:31 12.
HBV infection enhanced YTHDF2 O-GlcNAcylation in vitro
12:58 13.
OGT interacted with the N-terminal region of YTHDF2
23:00 14.
Ser263 is the major O-GlcNAcylation site of YTHDF2
29:00 15.
YTHDF2 protein was more stable after HBV infection in HCCKnockdown of OGT greatly shortened YTHDF2 lifespan
34:57 16.
TMG treatment could not restorereducing YTHDF2 half-life by S263A- YTHDF2 mutant
35:39 17.
Slide 15
35:40 18.
TMG treatment could not restorereducing YTHDF2 half-life by S263A- YTHDF2 mutant
38:36 19.
Slide 15
47:39 20.
O-GlcNAcylation of YTHDF2 promotes hepatocellular carcinoma cell proliferation, invasion and migration in vitro
49:57 21.
O-GlcNAcylation of YTHDF2 promotes tumor growth in vivo
50:37 22.
Identification of YTHDF2 targets by RNA-seq, m6A-seq and RIP-seq
58:19 23.
O-GlcNAcylation of YTHDF2 increased MCM2/5 mRNA stability in an m6A-dependent manner
1:06:02 24.
MCM2/5 promotes HCC proliferation by O-GlcNAcylation of YTHDF2
1:08:24 25.
Slide 21
1:10:38 26.
Slide 22
1:11:46 27.
Slide 23
1:12:37 28.
Slide 24
1:12:38 29.
Conclusion
1:13:33 30.
Comments
1:13:37 31.
Conclusion
1:14:02 32.
Comments
1:14:42 33.
Slide 27
1:15:11 34.
** after 20231030 meeting.pptx

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20231030 lab meeting_楷軒

Duration: 1:15:17, Browse: 204, Last Updated: 2023-10-30

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00:00 1.
index 1
00:28 2.
Slide 2
00:29 3.
HBV-related hepatocellular carcinoma
02:15 4.
HBV induces protein O-GlcNAcylation in liver cancer
03:29 5.
Hexosamine Biosynthetic Pathway (O-GlcNAcylation)
05:00 6.
RNA N6-methyladenosine (m6A) Modification
06:18 7.
Slide 7
06:42 8.
Slide 8
07:47 9.
HBV infection enhanced YTHDF2 O-GlcNAcylation in vivo and clinical
07:50 10.
Slide 8
07:58 11.
HBV infection enhanced YTHDF2 O-GlcNAcylation in vivo and clinical
10:31 12.
HBV infection enhanced YTHDF2 O-GlcNAcylation in vitro
12:58 13.
OGT interacted with the N-terminal region of YTHDF2
23:00 14.
Ser263 is the major O-GlcNAcylation site of YTHDF2
29:00 15.
YTHDF2 protein was more stable after HBV infection in HCCKnockdown of OGT greatly shortened YTHDF2 lifespan
34:57 16.
TMG treatment could not restorereducing YTHDF2 half-life by S263A- YTHDF2 mutant
35:39 17.
Slide 15
35:40 18.
TMG treatment could not restorereducing YTHDF2 half-life by S263A- YTHDF2 mutant
38:36 19.
Slide 15
47:39 20.
O-GlcNAcylation of YTHDF2 promotes hepatocellular carcinoma cell proliferation, invasion and migration in vitro
49:57 21.
O-GlcNAcylation of YTHDF2 promotes tumor growth in vivo
50:37 22.
Identification of YTHDF2 targets by RNA-seq, m6A-seq and RIP-seq
58:19 23.
O-GlcNAcylation of YTHDF2 increased MCM2/5 mRNA stability in an m6A-dependent manner
1:06:02 24.
MCM2/5 promotes HCC proliferation by O-GlcNAcylation of YTHDF2
1:08:24 25.
Slide 21
1:10:38 26.
Slide 22
1:11:46 27.
Slide 23
1:12:37 28.
Slide 24
1:12:38 29.
Conclusion
1:13:33 30.
Comments
1:13:37 31.
Conclusion
1:14:02 32.
Comments
1:14:42 33.
Slide 27
1:15:11 34.
** after 20231030 meeting.pptx

Location

Folder name

2023

Author

周楷軒

Branch

賴亮全教授

Created

2023-10-30 10:47:27

Last Updated

2023-10-30 11:17:48

Duration

1:15:17