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00:00
1.
Muscle Physiology
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00:17
2.
Goals of the Lecture
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00:34
3.
Outlines_Background
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00:35
3.1
Characteristics & Functions of Muscle
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01:54
3.2
Morphological Classification of Muscle
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03:15
3.3
Muscle Type and Activity
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04:02
4.
Outlines_Skeletal Muscle
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04:06
4.1
picture of skeletal muscles
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04:14
5.
Outlines_architecture & structure
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04:14
5.1
Shapes of Skeletal Muscle
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05:33
5.2
Skeletal Muscle Action
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09:12
5.3
Question: Are skeletal muscle an orgarn?
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11:15
5.4
Architecture of Skeletal Muscle
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13:20
5.5
Architecture of Skeletal Muscle
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14:18
5.6
Architecture of Skeletal Muscle
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15:15
5.7
Structure of Skeletal Myofiber1
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17:37
5.8
Structure of Skeletal Myofiber2
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19:04
5.9
Structure of Skeletal Myofiber3
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19:53
5.10
Architecture of Skeletal Muscle
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20:23
5.11
Thick Filament1
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21:30
5.12
Thick Filament2
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22:32
5.13
Question: Do thick filaments connect to Z-line?
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23:22
5.14
Thick Filament3
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23:46
5.15
Thin Filament1
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25:31
5.16
Thin Filament2
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27:26
5.17
Structure of Sarcomere1
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28:27
5.18
Structure of Sarcomere2
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33:30
5.19
If we did cross-section of skeletal muscles, which area can be seen the following:1. Thick filaments only H zone2. Thin filaments only I band3. Both thick and thin filaments C zone
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34:36
5.20
Architecture of Skeletal Muscle
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35:49
5.21
Summary: Architecture of Skeletal Muscle
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36:44
5.22
Video
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38:07
5.23
Sensory Receptors of Skeletal M.
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39:08
5.24
Structure of M. Spindle
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41:24
5.25
Structure of M. Spindle
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42:35
5.26
Structure of M. Spindle
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43:45
5.27
Question: How to maintain the sensitivity of afferent (sensory) nerve
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44:04
5.28
Sensitivity Modulation(α-γ Coactivation)
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46:17
5.29
Skeletal Muscle Repair
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46:52
5.30
Architecture of Skeletal Muscle
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47:05
5.31
Sliding Filaments
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48:41
5.32
Example Question
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49:33
5.33
Example Question
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51:16
5.34
Example Question
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53:08
6.
Outlines: Process of Skeletal M. Contraction
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53:13
6.1
Video
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54:35
6.2
Phases of M. Contraction
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55:04
6.3
Process of Skeletal Muscle Contraction
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55:34
6.4
Process of Skeletal Muscle Contraction
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55:38
6.5
Neuromuscular Junction1
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56:15
6.6
Neuromuscular Junction2
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57:05
6.7
Question: Why injection of Botulinum toxin (肉毒桿菌素) can reduce facial wrinkles?
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58:33
6.8
Cosmetic Aesthetic Medicine
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58:54
6.9
Question: What is the purpose of converting electrical signal to chemical signal?
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59:32
6.10
Neuromuscular Junction3
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1:00:08
6.11
Neuromuscular Junction4
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1:01:20
6.12
Neuromuscular Junction5
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1:03:05
6.13
Neuromuscular Junction6
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1:03:55
6.14
Question: How to prolong the function of Acetylcholine at neuromuscular junction?
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1:04:12
6.15
Neuromuscular Junction Disease
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1:05:46
6.16
Process of Skeletal Muscle Contraction
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1:08:13
6.17
Events of M. Contraction
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1:08:28
6.18
Events of M. Contraction
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1:09:45
6.19
Molecular Mechanisms of Contraction
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1:11:48
6.20
Crossbridge Cycle1
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1:16:39
6.21
Crossbridge Cycle2
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1:18:24
6.22
Summary of Crossbridge Cycle
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1:18:59
6.23
Animation
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1:20:21
6.24
Summary: Process of Skeletal Muscle Contraction
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1:21:11
6.25
Process of Skeletal Muscle Relaxation
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1:22:25
6.26
Muscle Cramps
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1:24:05
7.
Outlines: Control of Skeletal M. Contraction
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1:24:08
7.1
Question: Can voluntary muscles produce involuntary movement?
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1:24:18
7.2
Skeletal Muscle Reflexes
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1:25:10
7.3
Monosynaptic Stretch Reflex
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1:26:40
7.4
The response of skeletal m. is always excitatory. How to inhibit the response of skeletal muscle?Reduce the excitability of neuronActivation of antagonist
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1:28:13
7.5
Disynaptic Reflex
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1:28:27
7.6
Reciprocal Innervation
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1:30:08
8.
Outline: Mechanics of Skeletal M. Contraction
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1:30:17
8.1
Types of Muscle Contraction
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1:31:46
8.2
Isotonic Contraction With Different Loads
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1:32:13
8.3
Load-Velocity Relation
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1:32:30
8.4
Question: Are all-or-none law applied for muscle fibers?
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1:33:09
8.5
Different Response of M. Fiber vs. Whole Muscle
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1:34:34
8.6
Motor Unit1
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1:35:26
8.7
Motor Unit2
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1:36:42
8.8
Motor Unit3
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1:39:02
8.9
Muscle Tone
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1:40:39
8.10
Frequency-Tension Relation1
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1:42:57
8.11
Frequency-Tension Relation2
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1:43:02
8.12
Muscle Force1
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1:43:45
8.13
Muscle Force2
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1:44:30
8.14
Length-Tension Relation1
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1:45:37
8.15
Question: Why the active tension decreased when the muscle length is shorter than the normal resting length?
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1:45:56
8.16
Length-Tension Relation2
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1:47:52
8.17
Muscle Fatigue
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1:51:23
8.18
Causes of Muscular Fatigue
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1:54:18
9.
Outlines: Energetics of Skeletal M. Contraction
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1:54:22
9.1
Question: What are the energy sources of skeletal muscle contraction?
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1:54:33
9.2
Energy for Contraction1
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1:55:23
9.3
Energy for Contraction2
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1:56:05
9.4
Question: What does ATP do for providing energy in skeletal muscle contraction?
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1:56:42
9.5
Functions of ATP in Skeletal-Muscle Contraction
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1:56:57
9.6
Energy Sources in Working M.
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1:57:48
9.7
Types of Skeletal Muscle Fiber1
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2:00:45
9.8
Types of Skeletal Muscle Fiber2
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2:02:20
9.9
Question: Why can skeletal muscles be divided into red muscles and white muscles?
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2:03:32
9.10
Types of Skeletal Muscle Fiber2
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2:07:38
9.11
Exercise Training on Adaptation of Muscle Fibers
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2:09:06
9.12
Exercise Training on Adaptation of Muscle Fibers
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2:11:33
9.13
Myofascial Pain
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2:13:56
10.
Goals of the Lecture
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2:14:05
11.
Outlines: Structural Characteristics of smooth muscle
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2:14:06
11.1
Smooth Muscle
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2:14:18
11.2
Structural Characteristics of Smooth M1
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2:16:01
11.3
Structural Characteristics of Smooth M2
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2:17:50
11.4
Structural Characteristics of Smooth M3
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2:18:27
11.5
Structural Characteristics of Smooth M4
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2:19:36
11.6
Structural Characteristics of Smooth M5
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2:19:40
11.7
Structural Characteristics of Smooth M4
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2:20:14
11.8
Structural Characteristics of Smooth M5
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2:20:27
11.9
Voltage-Gated Channels in Smooth M.
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2:21:20
12.
Outlines: Smooth Muscle Contraction & Relaxation
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2:21:25
12.1
Single Muscle Twitch
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2:21:57
12.2
Smooth Muscle Contraction
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2:24:07
12.3
Mechanisms of Smooth M. Relaxation1
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2:24:58
12.4
Mechanisms of Smooth M. Relaxation2
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2:26:15
12.5
Smooth M. Latch State
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2:27:44
12.6
Unique Mechanical Properties
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2:29:13
12.7
Difference in Contraction Mechanism Between Smooth M. & Striated M.
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2:30:44
13.
Outlines: Classification of Smooth Muscle
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2:30:49
13.1
Classification of Smooth Muscle
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2:31:08
13.2
Single-Unit Smooth Muscle1
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2:32:21
13.3
Single-Unit Smooth Muscle2
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2:33:58
13.4
Single-Unit Smooth Muscle3
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2:36:04
13.5
Multiunit Smooth Muscle1
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2:37:13
13.6
Multiunit Smooth Muscle2
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2:38:07
14.
Goals of the Lecture
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2:38:27
15.
Outlines: Cardiac Muscle
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2:38:28
15.1
Cardiac Muscle
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2:38:33
15.2
Cardiac Muscle
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2:40:01
15.3
Characteristics of the Cardiac M.
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2:42:20
15.4
Automaticity (Chronotropic effect)
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2:43:13
15.5
Conductivity (Dromotropic effect)
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2:44:47
15.6
Action Potentials of contractile cardiac cellsPhase 0: Rapid depolarization (Na+ channels open, Na+ in)Phase 1: Rapid, partial early repolarization (Na+ channels close)Phase 2: Prolonged period of slow repolarization (Ca2+ channels open, Ca2+ in; fast K+
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2:45:53
15.7
Excitability
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2:47:00
15.8
Contractility (Inotropic effect)
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2:48:33
15.9
Contractility
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2:50:34
15.10
Contractility
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2:51:17
15.11
Contractility
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2:51:57
15.12
Contractility
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2:52:13
15.13
Mechanism of Cardiac Muscle Excitation, Contraction, & Relaxation (Lusitropic effect)
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2:55:46
15.14
Question: If a drug has a positive inotropic effect on heart, which means this drug can increase heart’s heart rate conductivity contractility relaxation excitability
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2:56:23
15.15
Excitation Contraction: Cardiac vs. Skeletal M.
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2:57:33
16.
Goals of the Lecture
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2:57:46
17.
Comparison of Skeletal, Cardiac, and Smooth Muscle
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2:58:33
18.
Comparison of Skeletal, Cardiac, and Smooth Muscle
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3:00:26
19.
Comparison of Skeletal, Cardiac, and Smooth Muscle
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3:03:01
20.
Comparison of Skeletal, Cardiac, and Smooth Muscle