學術著作

[Publication list]

T. Y. Lin, D. Jiang, W. R. Chen, J. S. Lin, X. Y. Zhang, C. H. Chen, C. L. Hsu, L. C. Lai, P. H. Chen, and K. C. Yang. (2023). Trained immunity induced by high‐salt diet impedes stroke recovery. EMBO reports:e57164.
W.-N. Lyu, M.-C. Lin, C.-Y. Shen, L.-H. Chen, Y.-H. Lee, S.-K. Chen, L.C. Lai, E. Y. Chuang, P.-J. Lou, and M.-H. Tsai. (2023). An Oral Microbial Biomarker for Early Detection of Recurrence of Oral Squamous Cell Carcinoma. ACS Infectious Diseases, 9:1783.
A. Chattopadhyay, C.-Y. Lee, Y.-C. Shen, K.-C. Lu, T.-H. Hsiao, C.-H. Lin, L.C. Lai., M.-H. Tsai, T.-P. Lu, and E. Y. Chuang. (2023). Multi-ethnic Imputation System (MI-System): A genotype imputation server for high-dimensional data. Journal of Biomedical Informatics, 143:104423.
T. Y. Wu, Y. T. Hsieh, Y. H. Wang, J. M. Chiou, T. F. Chen, L. C. Lai, J. H. Chen, and Y. C. Chen. (2023). The association between retinal vascular fractal dimension and cognitive function in the community-dwelling older adults cohort TIGER. J Formos Med Assoc, 10.1016/j.jfma.2023.04.001.
K.-Y. Lee, C.-M. Liu, L.-H. Chen, C.-Y. Lee, T.-P. Lu, L.-L. Chuang, and L.C. Lai. (2023). Hypoxia-responsive circular RNA circAAGAB reduces breast cancer malignancy by activating p38 MAPK and sponging miR-378 h. Cancer Cell International, 23:1.
H.-H. Chao, J.-L. Luo, M.-H. Hsu, L.-H. Chen, T.-P. Lu, M.-H. Tsai, E. Y. Chuang, L.-L. Chuang, and L.C. Lai. (2022). Regulatory mechanisms and function of hypoxia-induced long noncoding RNA NDRG1-OT1 in breast cancer cells. Cell Death & Disease, 13.
Y.-P. Hsieh, Y.-M. Hung, M.-H. Tsai, L.C. Lai, and E. Y. Chuang. (2022). 16S-ITGDB: An Integrated Database for Improving Species Classification of Prokaryotic 16S Ribosomal RNA Sequences. Frontiers in Bioinformatics, 2.
S. Shivani, C. Y. Kao, A. Chattopadhyay, J. W. Chen, L. C. Lai, W. H. Lin, T. P. Lu, I. H. Huang, M. H. Tsai, C. H. Teng, J. J. Wu, Y. H. Hsieh, M. C. Wang, and E. Y. Chuang. (2022). Uremic Toxin-Producing Bacteroides Species Prevail in the Gut Microbiota of Taiwanese CKD Patients: An Analysis Using the New Taiwan Microbiome Baseline. Front Cell Infect Microbiol, 12:726256.
Y. M. Hung, W. N. Lyu, M. L. Tsai, C. L. Liu, L. C. Lai, M. H. Tsai, and E. Y. Chuang. (2022). To compare the performance of prokaryotic taxonomy classifiers using curated 16S full-length rRNA sequences. Comput Biol Med, 145:105416.
M. Z. Chen, L. Y. Su, P. H. Ko, M. H. Hsu, L. L. Chuang, L. H. Chen, T. P. Lu, E. Y. Chuang, L. P. Chow, M. H. Tsai, H. H. Hsu, and L. C. Lai. (2022). Extracellular domain of semaphorin 5A serves a tumor‑suppressing role by activating interferon signaling pathways in lung adenocarcinoma cells. International Journal of Oncology, 60:1.
C. Lin, W. T. Tseng, Y. Y. Chang, M. H. Tsai, E. Y. Chuang, T. P. Lu, and L. C. Lai. (2022). Lidocaine and Bupivacaine Downregulate MYB and DANCR lncRNA by Upregulating miR-187-5p in MCF-7 Cells. Frontiers in Medicine, 8:2969.
Y.C. Huang, T.C. Tsai, C.H. Chang, K.T. Chang, P.H. Ko, L. C. Lai, Indoxyl Sulfate Elevated Lnc-SLC15A1-1 Upregulating CXCL10/CXCL8 Expression in High-Glucose Endothelial Cells by Sponging MicroRNAs. Toxins. 13 (2021) 873.
Y.H. Lin, J.M. Chiou, T.F. Chen, L. C. Lai, J.H. Chen, Y.C. Chen, The association between metabolic syndrome and successful aging- using an extended definition of successful aging. PLoS One. 16 (2021) e0260550.
W. Fang, C.H. Wu, Q. Sun, Z.T. Gu, L. Zhu, T. Mao, X.F. Zhang, N. Xu, T.P. Lu, M.H. Tsai, L.H. Chen, L. C. Lai, E.Y. Chuang, Novel Tumor-Specific Antigens for Immunotherapy Identified from Multi-omics Profiling in Thymic Carcinomas. Front Immunol. 4804.
C.H. Lu, C.H. Wu, M.H. Tsai, L. C. Lai, E.Y. Chuang, MutScape: an analytical toolkit for probing the mutational landscape in cancer genomics. NAR genomics and bioinformatics. 3 (2021) lqab099.
Chen JH, Shih HS, Tu J, Chiou JM, Chang SH, Hsu WL, L. C. Lai, Chen TF, and Chen YC. A Longitudinal Study on the Association of Interrelated Factors Among Frailty Dimensions, Cognitive Domains, Cognitive Frailty, and All-Cause Mortality. JOURNAL OF ALZHEIMER'S DISEASE. 2021. Oct 29.
Yu LCH, Wei SC, Li YH, Lin PY, Chang XY, Weng JP, Shue YW, L. C. Lai, Wang JT, and Jeng YM. Invasive Pathobionts Contribute to Colon Cancer Initiation by Counterbalancing Epithelial Antimicrobial Responses. Cellular and Molecular Gastroenterology and Hepatology. 2021.
Lin YS, Kuo TT, Lo CC, Cheng WC, Chang WC, Tseng GC, Bai ST, Huang YK, Hsieh CY, Hsu HS, Jiang YF, Lin CY, L. C. Lai, Li XG, and Sher YP. ADAM9 functions as a transcriptional regulator to drive angiogenesis in esophageal squamous cell carcinoma. Int J Biol Sci. 2021. 17:3898-3910.
Wu CH, Hsieh CS, Chang YC, Huang CC, Yeh HT, Hou MF, Chung YC, Tu SH, Chang KJ, Chattopadhyay A, L. C. Lai, Lu TP, Li YH, Tsai MH, and Chuang EY. Differential whole-genome doubling and homologous recombination deficiencies across breast cancer subtypes from the Taiwanese population. Communication Biology. 2021. Sep 9; 4:1052.
Lee CY, Lee YF, L. C. Lai, Tsai MH, Lu TP, and Chuang EY. MiDSystem: A Comprehensive Online System for De Novo Assembly and Analysis of Microbial Genomes. New Biotechnology. 2021. 65:42-52.
Phan NN, Chattopadhyay A, Lee TT, Yin HI, Lu TP, L. C. Lai, Hwa HL, Tsai MH, and Chuang EY. High-performance deep learning pipeline predicts individuals in mixtures of DNA using sequencing data. Briefings in Bioinformatics. 2021. Aug 7.
Chattopadhyay A, Teoh ZH, Wu CY, Juang JJ, L. C. Lai, Tsai MH, Wu CH, Lu TP, and Chuang EY. CNVIntegrate: the first multi-ethnic database for identifying copy number variations associated with cancer. Database (Oxford). 2021. Jul 14; 2021.
Cheng YC, Su LY, Chen LH, Lu TP, Chuang EY, Tsai MH, Chuang LL, and L. C. Lai. Regulatory Mechanisms and Functional Roles of Hypoxia-Induced Long Non-Coding RNA MTORT1 in Breast Cancer Cells. Frontiers in Oncology. 2021. 11:663114.
Hung YM, Tsai MH, L. C. Lai, and Chuang EY. ATTRACTIVE – An Auto-Updating Database for Experimental Protocols in Regenerative Medicine. IEEE Access. 2021. 9:75202-75210.
Shih CH, Chuang LL, Tsai MH, Chen LH, Chuang EY, Lu TP, and L. C. Lai. Hypoxia-Induced MALAT1 Promotes the Proliferation and Migration of Breast Cancer Cells by Sponging MiR-3064-5p. Frontiers in Oncology. 2021. 11:658151.
Wu CH, Yeh HT, Hsieh CS, Huang CC, Chattopadhyay A, Chung YC, Tu SH, Li YH, Lu TP, L. C. Lai, Hou MF, Chang KJ, Tsai MH, and Chuang EY. Evolutionary Trajectories and Genomic Divergence in Localized Breast Cancers after Ipsilateral Breast Tumor Recurrence. Cancers (Basel). 2021. Apr 11; 13.
Chin WY, He CY, Chow TW, Yu QY, L. C. Lai, and Miaw SC. Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1alpha and AMPK in Macrophages. Frontiers in Immunology. 2021. 12:630318.
Hung YM, Lu TP, Tsai MH, L. C. Lai, and Chuang EY. EasyMAP: A user-friendly online platform for analyzing 16S ribosomal DNA sequencing data. New Biotechnology. 2021. Mar 9; 63:37-44.
Y.M. Hung, L. C. Lai, Factors to be considered in designing frameworks for automated bioinformatics pipelines—a perspective based on application setting. Transl Cancer Res. 9 (2020) 7382-7383.
H. C. Lo, J. H. Hsu, L. C. Lai, M. H. Tsai, and E. Y. Chuang. (2020, Sep 3). MicroRNA-107 enhances radiosensitivity by suppressing granulin in PC-3 prostate cancer cells. Scientific Reports, 10:14584.
Lin CC, Huang YK, Cho CF, Lin YS, Lo CC, Kuo TT, Tseng GC, Cheng WC, Chang WC, Hsiao TH, L. C. Lai, Shih JY, Liu YH, Chao KSC, Hsu JL, Lee PC, Sun X, Hung MC, and Sher YP. Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression. Theranostics. 2020. 10:10925-10939.
Chou YH, Pan SY, Shao YH, Shih HM, Wei SY, Lai CF, Chiang WC, Schrimpf C, Yang KC, L. C. Lai, Chen YM, Chu TS, and Lin SL. Methylation in pericytes after acute injury promotes chronic kidney disease. The Journal of Clinical Investigation. 2020. Aug 4; 10.1172/JCI135773.
Juang JJ, Binda A, Lee SJ, Hwang JJ, Chen WJ, Liu YB, Lin LY, Yu CC, Ho LT, Huang HC, Chen CJ, Lu TP, L. C. Lai, Yeh SS, Lai LP, Chuang EY, Rivolta I, and Antzelevitch C. GSTM3 variant is a novel genetic modifier in Brugada syndrome, a disease with risk of sudden cardiac death. EBioMedicine. 2020. Jul; 57:102843.
Huang YS, L. C. Lai, Chen YA, Lin KY, Chou YH, Chen HC, Wang SS, Wang JT, and Chang SC. Colonization with multidrug-resistant organisms among healthy adults in the community setting: prevalence, risk factors, and composition of gut microbiome. Frontiers in Microbiology. 2020. Jun 24; 11:1402.
Chen CH, Chen YF, Tsai PH, Chiou JM, L. C. Lai, Chen TF, Hung H, Chen JH, and Chen YC. Impacts of kidney dysfunction and cerebral cortical thinning on cognitive change in elderly population. Journal of Alzheimer's Disease. 2020. May 19.
Chao KH, Hsiao YW, Lee YF, Lee CY, L. C. Lai, Tsai MH, Lu TP, and Chuang EY. RNASeqR: an R package for automated two-group RNA-Seq analysis workflow. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2019. Dec 2.
W.C. Lin, L.H. Chen, Y.C. Hsieh, P.W. Yang, L. C. Lai, E.Y. Chuang, J.M. Lee, M.H. Tsai, miR-338-5p inhibits cell proliferation, colony formation, migration, and cisplatin resistance in esophageal squamous cancer cells by targeting FERMT2. Carcinogenesis. 40 (2019) 883-892.
Ko PH, Lenka G, Chen YA, Chuang EY, Tsai MH, Sher YP, and L. C. Lai. Semaphorin 5A suppresses the proliferation and migration of lung adenocarcinoma cells. International Journal of Oncology. 2019. Dec 2:10.3892/ijo.2019.4932.
Huang YC, and L. C. Lai. The potential roles of stem cell-derived extracellular vesicles as a therapeutic tool. Annals of Translational Medicine. 2019. Nov 10:10.21037/atm.2019.11.66.
Wang CH, Chang RW, Wu ET, Hsiao YJ, Wu MS, Yu HY, Chen YS, L. C. Lai, and Yu SL. Extracorporeal life support enhances the forward pressure wave to cause a mismatch between cardiac oxygen demand and supply. Scientific Reports. 2019. Sep 25; 9:13882.
Chen LH, Liao CY, L. C. Lai, Tsai MH, and Chuang EY. Semaphorin 6A attenuates the migration capability of lung cancer cells via the NRF2/HMOX1 axis. Scientific Reports. 2019. Sep 16; 9:13302.
L. C. Lai, Sun QL, Chen YA, Hsiao YW, Lu TP, Tsai MH, Zhu L, Chuang EY, and Fang W. Using proteomic profiling to characterize protein signatures of different thymoma subtypes. BMC Cancer. 2019. Aug 13; 19:796.
Wang TT, Lee CY, L. C. Lai, Tsai MH, Lu TP, and Chuang EY. anamiR: integrated analysis of MicroRNA and gene expression profiling. BMC Bioinformatics. 2019. May 14; 20:239.
Ko PH, Huang CW, Chang HH, Chuang EY, Tsai MH, and L. C. Lai. Identifying the functions and biomarkers of Codonopsis pilosula and Astragalus membranaceus aqueous extracts in hepatic cells. Chinese Medicine. 2019. Mar; 14:10.
Ko PH, Shen YC, Murugan K, Huang CW, Sivakumar G, Pal P, Liao CC, Luo KS, Chuang EY, Tsai MH, and L. C. Lai. Macrophage migration inhibitory factor acts as the potential target of a newly synthesized compound, 1-(9′-methyl-3′-carbazole)-3, 4-dihydro-β-carboline. Scientific Reports. 2019. Feb 14; 9:2147.
Lee CY, Chattopadhyay A, Chiang LM, Juang JJ, L. C. Lai, Tsai MH, Lu TP, and Chuang EY. VariED: the first integrated database of gene annotation and expression profiles for variants related to human diseases. Database (Oxford). 2019. Jan 1; 2019:10.1093/database/baz075.
Shen CY, Chang YC, Chen LH, Lin WC, Lee YH, Yeh ST, Chen HK, Fang W, Hsu CP, Lee JM, Lu TP, Hsiao PW, L. C. Lai, Tsai MH, and Chuang EY. The extracellular SEMA domain attenuates intracellular apoptotic signaling of semaphorin 6A in lung cancer cells. Oncogenesis. 2018. Dec 5; 7:95.
Yeh CC, Luo JL, Nhut Phan N, Cheng YC, Chow LP, Tsai MH, Chuang EY, and L. C. Lai. Different effects of long noncoding RNA NDRG1-OT1 fragments on NDRG1 transcription in breast cancer cells under hypoxia. RNA Biology. 2018. Nov 30.
Lee, C. Y., P. H. Hsieh, L. M. Chiang, A. Chattopadhyay, K. Y. Li, Y. F. Lee, T. P. Lu, L. C. Lai, E. C. Lin, H. Lee, S. T. Ding, M. H. Tsai, C. Y. Chen, and E. Y. Chuang. Whole-genome de novo sequencing reveals unique genes that contributed to the adaptive evolution of the Mikado pheasant. Gigascience. 2018. May 1; 7.
Tseng, T. C., D. Y. Huang, L. C. Lai, H. Hwai, Y. W. Hsiao, J. P. Jhou, E. Y. Chuang, and S. J. Tzeng. Dual immuno-renal targeting of 7-benzylidenenaltrexone alleviates lupus nephritis via FcgammaRIIB and HO-1. Journal of Molecular Medicine. 2018. Mar; 10.1007/s00109-018-1626-9.
Lin, H. C., C. C. Yeh, L. Y. Chao, M. H. Tsai, H. H. Chen, E. Y. Chuang, and L. C. Lai. The hypoxia-responsive lncRNA NDRG-OT1 promotes NDRG1 degradation via ubiquitin-mediated proteolysis in breast cancer cells. Oncotarget. 2018. Feb; 9:10470-10482.
Huang, S. H., Y. S. Chang, J. J. Juang, K. W. Chang, M. H. Tsai, T. P. Lu, L. C. Lai, E. Y. Chuang, and N. T. Huang. An automated microfluidic DNA microarray platform for genetic variant detection in inherited arrhythmic diseases. Analyst. 2018. Feb 9; 10.1039/c7an01648d.
Lee, Y. F., C. Y. Lee, L. C. Lai, M. H. Tsai, T. P. Lu, and E. Y. Chuang. CellExpress: a comprehensive microarray-based cancer cell line and clinical sample gene expression analysis online system. Database-the Journal of Biological Databases and Curation. 2018. Jan; 10.1093/database/bax101.
Chang, Y. Y., L. C. Lai, M. H. Tsai, and E. Y. Chuang. Deep sequencing reveals a microRNA expression signature in triple-negative breast cancer. Methods in Molecular Biology. 2018. 1699:99-111.
Wang, C. H., R. W. Chang, C. Y. Chang, M. S. Wu, H. L. Kao, L. C. Lai, T. H. Young, H. Y. Yu, Y. S. Chen, and K. C. Chang. Quantification of contractile mechanics in the rat heart from ventricular pressure alone. Oncotarget. 2017. Nov 10; 8:96161-96170.
Lin, C. Y., C. F. Cho, S. T. Bai, J. P. Liu, T. T. Kuo, L. J. Wang, Y. S. Lin, C. C. Lin, L. C. Lai, T. P. Lu, C. Y. Hsieh, C. N. Chu, D. C. Cheng, and Y. P. Sher. ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT. Scientific Reports. 2017. Nov; 7:15108.
Wei, S. C., H. F. Yang-Yen, P. N. Tsao, M. T. Weng, C. C. Tung, L. C. H. Yu, L. C. Lai, J. H. Hsiao, E. Y. Chuang, C. T. Shun, Y. H. Ni, R. J. Xavier, D. K. Podolsky, J. J. Y. Yen, and J. M. Wong. SHANK3 regulates intestinal barrier function through modulating ZO-1 expression through the PKCepsilon-dependent pathway. Inflammatory Bowel Diseases. 2017. Oct; 23:1730-1740.
Chiu, K. L., Y. S. Lin, T. T. Kuo, C. C. Lo, Y. K. Huang, H. F. Chang, E. Y. Chuang, C. C. Lin, W. C. Cheng, Y. N. Liu, L. C. Lai, and Y. P. Sher. ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis. Oncotarget. 2017. Jul; 8:47365-47378.
Chang, C. Y., R. W. Chang, S. H. Hsu, M. S. Wu, Y. J. Cheng, H. L. Kao, L. C. Lai, C. H. Wang, and K. C. Chang. Defects in vascular mechanics due to aging in rats: studies on arterial wave properties from a single aortic pressure pulse. Frontiers in Physiology. 2017. Jul; 8:503.
Lenka, G., M. H. Tsai, H. C. Lin, J. H. Hsiao, Y. C. Lee, T. P. Lu, J. M. Lee, C. P. Hsu, L. C. Lai, and E. Y. Chuang. Identification of methylation-driven, differentially expressed STXBP6 as a novel biomarker in lung adenocarcinoma. Scientific Reports. 2017. Feb; 7:42573.
Chang, R. W., C. Y. Chang, L. C. Lai, M. S. Wu, T. H. Young, Y. S. Chen, C. H. Wang, and K. C. Chang. Determining arterial wave transit time from a single aortic pressure pulse in rats: vascular impulse response analysis. Scientific Reports. 2017. Jan; 7:40998.
Lai, Y. P., L. B. Wang, W. A. Wang, L. C. Lai, M. H. Tsai, T. P. Lu, and E. Y. Chuang. iGC-an integrated analysis package of gene expression and copy number alteration. BMC Bioinformatics. 2017. Jan; 18:35.
Shen, C. Y., L. H. Chen, Y. F. Lin, L. C. Lai, E. Y. Chuang, and M. H. Tsai. Mitomycin C treatment induces resistance and enhanced migration via phosphorylated Akt in aggressive lung cancer cells. Oncotarget. 2016. Nov; 7:79995-80007.
Wang, W. A., L. C. Lai, M. H. Tsai, T. P. Lu, and E. Y. Chuang. Development of a prediction model for radiosensitivity using the expression values of genes and long non-coding RNAs. Oncotarget. 2016. May; 7:26739-50.
Lenka, G., M. H. Tsai, J. H. Hsiao, L. C. Lai, and E. Y. Chuang. Overexpression of methylation-driven DCC suppresses proliferation of lung cancer cells. Translational Cancer Research. 2016. Apr; 5:169-175.
Hsiao, T. H., Y. C. Chiu, P. Y. Hsu, T. P. Lu, L. C. Lai, M. H. Tsai, T. H. Huang, E. Y. Chuang, and Y. Chen. Differential network analysis reveals the genome-wide landscape of estrogen receptor modulation in hormonal cancers. Scientific Reports. 2016. Mar; 6:23035.
Chiu, Y. C., M. H. Tsai, W. C. Chou, Y. C. Liu, Y. Y. Kuo, H. A. Hou, T. P. Lu, L. C. Lai, Y. Chen, H. F. Tien, and E. Y. Chuang. Prognostic significance of NPM1 mutation-modulated microRNA-mRNA regulation in acute myeloid leukemia. Leukemia. 2016. Feb; 30:274-84.
Li, E. Y., W. Y. Huang, Y. C. Chang, M. H. Tsai, E. Y. Chuang, Q. Y. Kuok, S. T. Bai, L. Y. Chao, Y. P. Sher, and L. C. Lai. Aryl hydrocarbon receptor activates NDRG1 transcription under hypoxia in breast cancer cells. Scientific Reports. 2016. Feb; 6:20808.
Chang, R. W., C. Y. Chang, M. S. Wu, H. Y. Yu, J. M. Luo, Y. S. Chen, F. Y. Lin, L. C. Lai, C. H. Wang, and K. C. Chang. Systolic aortic pressure-time area is a useful index describing arterial wave properties in rats with diabetes. Scientific Reports. 2015. Dec; 5:17293.
Chiu, K. L., T. T. Kuo, Q. Y. Kuok, Y. S. Lin, C. H. Hua, C. Y. Lin, P. Y. Su, L. C. Lai, and Y. P. Sher. ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumor metastasis. Scientific Reports. 2015. Nov; 5:16426.
Woolston, A., N. Sintupisut, T. P. Lu, L. C. Lai, M. H. Tsai, E. Y. Chuang, and C. H. Yeang. Putative effectors for prognosis in lung adenocarcinoma are ethnic and gender specific. Oncotarget. 2015. Aug; 6:19483-99.
Kang, Y., Y. Y. Chang, Y. C. Liu, L. C. Lai, E. Y. Chuang, and M. H. Tsai. A microarray study of radiation-induced transcriptional responses and the role of Jagged 1 in two closely-related lung cancer cell lines. Translational Cancer Research. 2015. 4:314-323.
Lu, T. P., C. K. Hsiao, L. C. Lai, M. H. Tsai, C. P. Hsu, J. M. Lee, and E. Y. Chuang. Identification of regulatory SNPs associated with genetic modifications in lung adenocarcinoma. BMC Research Notes. 2015. Mar; 8:92.
Chang, Y. Y., W. H. Kuo, J. H. Hung, C. Y. Lee, Y. H. Lee, Y. C. Chang, W. C. Lin, C. Y. Shen, C. S. Huang, F. J. Hsieh, L. C. Lai, M. H. Tsai, K. J. Chang, and E. Y. Chuang. Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing. Molecular Cancer. 2015. Feb; 14:301.
Juang, J. M., T. P. Lu, L. C. Lai, C. C. Ho, Y. B. Liu, C. T. Tsai, L. Y. Lin, C. C. Yu, W. J. Chen, F. T. Chiang, S. F. Yeh, L. P. Lai, E. Y. Chuang, and J. L. Lin. Disease-targeted sequencing of ion channel genes identifies de novo mutations in patients with non-familial Brugada syndrome. Scientific Reports. 2014. Oct; 4:6733.
Huang, C. C., S. H. Tu, H. H. Lien, C. S. Huang, C. J. Huang, L. C. Lai, M. H. Tsai, and E. Y. Chuang. Refinement of breast cancer risk prediction with concordant leading edge subsets from prognostic gene signatures. Breast Cancer Research and Treatment. 2014. Sep; 147:353-70.
Lin, C. Y., H. J. Chen, C. C. Huang, L. C. Lai, T. P. Lu, G. C. Tseng, T. T. Kuo, Q. Y. Kuok, J. L. Hsu, S. Y. Sung, M. C. Hung, and Y. P. Sher. ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway. Cancer Research. 2014. Sep; 74:5229-43.
Lu, T. P., Y. Y. Hsu, L. C. Lai, M. H. Tsai, and E. Y. Chuang. Identification of gene expression biomarkers for predicting radiation exposure. Scientific Reports. 2014. Sep; 4:6293.
Luo, E. C., Y. C. Chang, Y. P. Sher, W. Y. Huang, L. L. Chuang, Y. C. Chiu, M. H. Tsai, E. Y. Chuang, and L. C. Lai. MicroRNA-769-3p down-regulates NDRG1 and enhances apoptosis in MCF-7 cells during reoxygenation. Scientific Reports. 2014. Aug; 4:5908.
Wei, S. C., Y. Y. Tan, M. T. Weng, L. C. Lai, J. H. Hsiao, E. Y. Chuang, C. T. Shun, D. C. Wu, A. W. Kao, C. S. Chuang, Y. H. Ni, M. J. Shieh, C. C. Tung, Y. Chen, C. Y. Wang, R. J. Xavier, D. K. Podolsky, and J. M. Wong. SLCO3A1, a novel Crohn's disease-associated gene, regulates NF-kappaB activity and associates with intestinal perforation. PLoS One. 2014. Jun; 9:e100515.
Sher, Y. P., L. J. Wang, L. L. Chuang, M. H. Tsai, T. T. Kuo, C. C. Huang, E. Y. Chuang, and L. C. Lai. ADAM9 up-regulates N-cadherin via miR-218 suppression in lung adenocarcinoma cells. PLoS One. 2014. Apr; 9:e94065.
L. C. Lai, M. H. Tsai, P. C. Chen, L. H. Chen, J. H. Hsiao, S. K. Chen, T. P. Lu, J. M. Lee, C. P. Hsu, C. K. Hsiao, and E. Y. Chuang. SNP rs10248565 in HDAC9 as a novel genomic aberration biomarker of lung adenocarcinoma in non-smoking women. Journal of Biomedical Science. 2014. Mar; 21:24.
Lu, T. P., K. T. Chen, M. H. Tsai, K. T. Kuo, C. K. Hsiao, L. C. Lai, and E. Y. Chuang. Identification of genes with consistent methylation levels across different human tissues. Scientific Reports. 2014. Mar; 4:4351.
Huang, C. C., S. H. Tu, H. H. Lien, J. Y. Jeng, J. S. Liu, C. S. Huang, L. C. Lai, and E. Y. Chuang. Estrogen receptor status prediction by gene component regression: a comparative study. International Journal of Data Mining and Bioinformatics. 2014. Feb; 9:149-71.
Juang, J. M., T. P. Lu, L. C. Lai, C. H. Hsueh, Y. B. Liu, C. T. Tsai, L. Y. Lin, C. C. Yu, J. J. Hwang, F. T. Chiang, S. S. Yeh, W. P. Chen, E. Y. Chuang, L. P. Lai, and J. L. Lin. Utilizing multiple in silico analyses to identify putative causal SCN5A variants in Brugada syndrome. Scientific Reports. 2014. Jan; 4:3850.
Huang, C. C., S. H. Tu, C. S. Huang, H. H. Lien, L. C. Lai, and E. Y. Chuang. Multiclass prediction with partial least square regression for gene expression data: applications in breast cancer intrinsic taxonomy. BioMed Research International. 2013. Nov; 2013:1-9.
Huang, C. C., S. H. Tu, H. H. Lien, J. Y. Jeng, C. S. Huang, C. J. Huang, L. C. Lai, and E. Y. Chuang. Concurrent gene signatures for Han Chinese breast cancers. PLoS One. 2013. Oct; 8:e76421.
Lai, T. Y., S. D. Wu, M. H. Tsai, E. Y. Chuang, L. L. Chuang, L. C. Hsu, and L. C. Lai. Transcription of Tnfaip3 is regulated by NF-kappaB and p38 via C/EBPbeta in activated macrophages. PLoS One. 2013. Sep; 8:e73153.
Chen, P. C., T. P. Lu, J. C. Chang,L. C. Lai, M. H. Tsai, C. K. Hsiao, and E. Y. Chuang. Concurrent analysis of copy number variation and gene expression: application in paired non-smoking female lung cancer patients. International Journal of Data Mining and Bioinformatics. 2013. Jul; 8:92-104.
Wu, F. C., L. C. Lai, Y. H. Kuo, Y. H. Lee, F. H. Hsu, C. Y. Shen, E. Y. Chuang, and M. H. Tsai. Differential genomic alterations in normal and cancerous lung cells in response to chronic inflammation. Translational Cancer Research. 2013. Apr; 2:64-73.
Liu, Y. J., Y. F. Lin, Y. F. Chen, E. C. Luo, Y. P. Sher, M. H. Tsai, E. Y. Chuang, and L. C. Lai. MicroRNA-449a enhances radiosensitivity in CL1-0 lung adenocarcinoma cells. PLoS One. 2013. Apr; 8:e62383.
Huang, C. C., J. Y. Jeng, S. H. Tu, H. H. Lien, C. S. Huang, L. C. Lai, and E. Y. Chuang. A preliminary study of concurrent gains and losses across gene expression profiles and comparative genomic hybridization in Taiwanese breast cancer patients. Translational Cancer Research. 2013. Feb; 2:18-24.
L. C. Lai Using gene set signature to guide hypothesis-driven experiments. Translational Cancer Research. 2013. Feb; 2:1-2.
Lee, C. H., Y. C. Chiu, L. B. Wang, Y. L. Kuo, E. Y. Chuang, L. C. Lai, and M. H. Tsai. Common applications of next-generation sequencing technologies in genomic research. Translational Cancer Research. 2013. Feb; 2:33-45.
Lin, S. Y., S. C. Hsieh, Y. C. Lin, C. N. Lee, M. H. Tsai, L. C. Lai, E. Y. Chuang, P. C. Chen, C. C. Hung, L. Y. Chen, W. S. Hsieh, D. M. Niu, Y. N. Su, and H. N. Ho. A whole genome methylation analysis of systemic lupus erythematosus: hypomethylation of the IL10 and IL1R2 promoters is associated with disease activity. Genes Immunity. 2012. Nov; 13:214.
Huang, C. C., S. H. Tu, H. H. Lien, J. Y. Jeng, J. S. Liu, C. S. Huang, Y. Y. Wu, C. Y. Liu, L. C. Lai, and E. Y. Chuang. Prediction consistency and clinical presentations of breast cancer molecular subtypes for Han Chinese population. Journal of Translational Medicine. 2012. Sep; 10 Suppl 1:S10.
Kuo, W. H., Y. Y. Chang, L. C. Lai, M. H. Tsai, C. K. Hsiao, K. J. Chang, and E. Y. Chuang. Molecular characteristics and metastasis predictor genes of triple-negative breast cancer: a clinical study of triple-negative breast carcinomas. PLoS One. 2012. Sep; 7:e45831.
Lu, T. P., C. Y. Lee, M. H. Tsai, Y. C. Chiu, C. K. Hsiao, L. C. Lai, and E. Y. Chuang. miRSystem: An integrated system for characterizing enriched functions and pathways of microRNA targets. PLoS One. 2012. Aug; 7:e42390.
Chen, P. C., Y. C. Chen, L. C. Lai, M. H. Tsai, S. K. Chen, P. W. Yang, Y. C. Lee, C. K. Hsiao, J. M. Lee, and E. Y. Chuang. Use of germline polymorphisms in predicting concurrent chemoradiotherapy response in esophageal cancer. International Journal of Radiation Oncology • Biology • Physics. 2012. May; 82:1996-2003.
Lu, T. P., M. H. Tsai, C. K. Hsiao, L. C. Lai, and E. Y. Chuang. Expression and functions of semaphorins in cancer. Translational Cancer Research. 2012. Apr; 1:74-78.
Chen, S. Y., T. F. Chen, L. C. Lai, J. H. Chen, Y. Sun, L. L. Wen, P. K. Yip, Y. M. Chu, and Y. C. Chen. Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease. Journal of Neuroinflammation. 2012. Jan; 9:21.
Chen, Y. C., L. C. Lai, Y. P. Tu, S. D. Wu, C. F. Chen, and B. Li. Far infrared ray irradiation attenuates apoptosis and cell death of cultured keratinocytes stressed by dehydration. Journal of Photochemistry and Photobiology B: Biology. 2012. Jan; 106:61-8.
Cheng, H. C., Y. Sun, L. C. Lai, S. Y. Chen, W. C. Lee, J. H. Chen, T. F. Chen, H. H. Chen, L. L. Wen, P. K. Yip, Y. M. Chu, W. J. Chen, and Y. C. Chen. Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease. Journal of Negative Results in BioMedicine. 2012. Jan; 11:5.
Lin, Y. L., S. Y. Chen, L. C. Lai, J. H. Chen, S. Y. Yang, Y. L. Huang, T. F. Chen, Y. Sun, L. L. Wen, P. K. Yip, Y. M. Chu, W. J. Chen, and Y. C. Chen. Genetic polymorphisms of clusterin gene are associated with a decreased risk of Alzheimer's disease. European Journal of Epidemiology. 2012. Jan; 27:73-75.
Chen, L. H., W. H. Kuo, M. H. Tsai, P. C. Chen, C. K. Hsiao, E. Y. Chuang, L. Y. Chang, F. J. Hsieh, L. C. Lai, and K. J. Chang. Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan. PLoS One. 2011. Nov; 6:e28222.
Hsu, F. H., H. I. Chen, M. H. Tsai, L. C. Lai, C. C. Huang, S. H. Tu, E. Y. Chuang, and Y. Chen. A model-based circular binary segmentation algorithm for the analysis of array CGH data. BMC Research Notes. 2011. Oct.; 4:394.
Lu, T. P., L. C. Lai, M. H. Tsai, P. C. Chen, C. P. Hsu, J. M. Lee, C. K. Hsiao, and E. Y. Chuang. Integrated analyses of copy number variations and gene expression in lung adenocarcinoma. PLoS One. 2011. Sep; 6:e24829.
L. C. Lai, Y. Y. Su, K. C. Chen, M. H. Tsai, Y. P. Sher, T. P. Lu, C. Y. Lee, and E. Y. Chuang. Down-regulation of NDRG1 promotes migration of cancer cells during reoxygenation. PLoS One. 2011. Aug; 6:e24375.
Kuo, H. C., P. Y. Lin, T. C. Chung, C. M. Chao, L. C. Lai, M. H. Tsai, and E. Y. Chuang. DBCAT: Database of CpG islands and analytical tools for identifying comprehensive methylation profiles in cancer cells. Journal of Computational Biology. 2011. Aug; 18:1013-7.
Lin, K. P., S. Y. Chen, L. C. Lai, Y. L. Huang, J. H. Chen, T. F. Chen, Y. Sun, L. L. Wen, P. K. Yip, Y. M. Chu, W. J. Chen, and Y. C. Chen. Genetic polymorphisms of a novel vascular susceptibility gene, Ninjurin2 (NINJ2), are associated with a decreased risk of Alzheimer's disease. PLoS One. 2011. Jun.; 6:e20573.
Hsu, L. C., T. Enzler, J. Seita, A. M. Timmer, C. Y. Lee, T. Y. Lai, G. Y. Yu, L. C. Lai, V. Temkin, U. Sinzig, T. Aung, V. Nizet, I. L. Weissman, and M. Karin. IL-1beta-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKbeta. Nature Immunology. 2011. Feb; 12:144-50.
Lu, T. P., M. H. Tsai, J. M. Lee, C. P. Hsu, P. C. Chen, C. W. Lin, J. Y. Shih, P. C. Yang, C. K. Hsiao, L. C. Lai, and E. Y. Chuang. Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women. Cancer Epidemiology, Biomarkers & Prevention. 2010. Oct; 19:2590-7.
Lu, T. P., L. C. Lai, B. I. Lin, L. H. Chen, T. H. Hsiao, H. L. Liber, J. A. Cook, J. B. Mitchell, M. H. Tsai, and E. Y. Chuang. Distinct signaling pathways after higher or lower doses of radiation in three closely related human lymphoblast cell lines. International Journal of Radiation Oncology • Biology • Physics. 2010. Jan; 76:212-9.
L. C. Lai, M. T. Kissinger, P. V. Burke, and K. E. Kwast. Comparison of the transcriptomic "stress response" evoked by antimycin A and oxygen deprivation in Saccharomyces cerevisiae. BMC Genomics. 2008. Dec; 9:627.
L. C. Lai, A. L. Kosorukoff, P. V. Burke, and K. E. Kwast. Metabolic-state-dependent remodeling of the transcriptome in response to anoxia and subsequent reoxygenation in Saccharomyces cerevisiae. Eukaryotic Cell. 2006. Sep; 5:1468-89.
L. C. Lai, A. L. Kosorukoff, P. V. Burke, and K. E. Kwast. Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media. Molecular and Cellular Biology. 2005. May; 25:4075-91.
Burke, P. V., L. C. Lai, and K. E. Kwast. A rapid filtration apparatus for harvesting cells under controlled conditions for use in genome-wide temporal profiling studies. Analytical Biochemistry. 2004. May; 328:29-34.
Kwast, K. E., L. C. Lai, N. Menda, D. T. James, 3rd, S. Aref, and P. V. Burke. Genomic analyses of anaerobically induced genes in Saccharomyces cerevisiae: functional roles of Rox1 and other factors in mediating the anoxic response. Journal of Bacteriology. 2002. Jan; 184:250-65.
Lai, Y. L., S. C. Lee, L. C. Lai, F. C. Hu, T. L. Tsai, and Y. F. Tsai. Catecholamines in hyperpnoea-induced airway constriction of guinea pigs. Journal of Autonomic Pharmacology. 2001. Jun; 21:151-7.
Lai, Y. L., C. W. Lin, and L. C. Lai. Attenuation of isocapnic hyperpnoea-induced guinea-pig bronchoconstriction by chronic hypoxia. European Respiratory Journal. 1998. May; 11:1075-80.

學術著作

[Publication list]

T. Y. Lin, D. Jiang, W. R. Chen, J. S. Lin, X. Y. Zhang, C. H. Chen, C. L. Hsu, L. C. Lai, P. H. Chen, and K. C. Yang. (2023). Trained immunity induced by high‐salt diet impedes stroke recovery. EMBO reports:e57164.
W.-N. Lyu, M.-C. Lin, C.-Y. Shen, L.-H. Chen, Y.-H. Lee, S.-K. Chen, L.C. Lai, E. Y. Chuang, P.-J. Lou, and M.-H. Tsai. (2023). An Oral Microbial Biomarker for Early Detection of Recurrence of Oral Squamous Cell Carcinoma. ACS Infectious Diseases, 9:1783.
A. Chattopadhyay, C.-Y. Lee, Y.-C. Shen, K.-C. Lu, T.-H. Hsiao, C.-H. Lin, L.C. Lai., M.-H. Tsai, T.-P. Lu, and E. Y. Chuang. (2023). Multi-ethnic Imputation System (MI-System): A genotype imputation server for high-dimensional data. Journal of Biomedical Informatics, 143:104423.
T. Y. Wu, Y. T. Hsieh, Y. H. Wang, J. M. Chiou, T. F. Chen, L. C. Lai, J. H. Chen, and Y. C. Chen. (2023). The association between retinal vascular fractal dimension and cognitive function in the community-dwelling older adults cohort TIGER. J Formos Med Assoc, 10.1016/j.jfma.2023.04.001.
K.-Y. Lee, C.-M. Liu, L.-H. Chen, C.-Y. Lee, T.-P. Lu, L.-L. Chuang, and L.C. Lai. (2023). Hypoxia-responsive circular RNA circAAGAB reduces breast cancer malignancy by activating p38 MAPK and sponging miR-378 h. Cancer Cell International, 23:1.
H.-H. Chao, J.-L. Luo, M.-H. Hsu, L.-H. Chen, T.-P. Lu, M.-H. Tsai, E. Y. Chuang, L.-L. Chuang, and L.C. Lai. (2022). Regulatory mechanisms and function of hypoxia-induced long noncoding RNA NDRG1-OT1 in breast cancer cells. Cell Death & Disease, 13.
Y.-P. Hsieh, Y.-M. Hung, M.-H. Tsai, L.C. Lai, and E. Y. Chuang. (2022). 16S-ITGDB: An Integrated Database for Improving Species Classification of Prokaryotic 16S Ribosomal RNA Sequences. Frontiers in Bioinformatics, 2.
S. Shivani, C. Y. Kao, A. Chattopadhyay, J. W. Chen, L. C. Lai, W. H. Lin, T. P. Lu, I. H. Huang, M. H. Tsai, C. H. Teng, J. J. Wu, Y. H. Hsieh, M. C. Wang, and E. Y. Chuang. (2022). Uremic Toxin-Producing Bacteroides Species Prevail in the Gut Microbiota of Taiwanese CKD Patients: An Analysis Using the New Taiwan Microbiome Baseline. Front Cell Infect Microbiol, 12:726256.
Y. M. Hung, W. N. Lyu, M. L. Tsai, C. L. Liu, L. C. Lai, M. H. Tsai, and E. Y. Chuang. (2022). To compare the performance of prokaryotic taxonomy classifiers using curated 16S full-length rRNA sequences. Comput Biol Med, 145:105416.
M. Z. Chen, L. Y. Su, P. H. Ko, M. H. Hsu, L. L. Chuang, L. H. Chen, T. P. Lu, E. Y. Chuang, L. P. Chow, M. H. Tsai, H. H. Hsu, and L. C. Lai. (2022). Extracellular domain of semaphorin 5A serves a tumor‑suppressing role by activating interferon signaling pathways in lung adenocarcinoma cells. International Journal of Oncology, 60:1.
C. Lin, W. T. Tseng, Y. Y. Chang, M. H. Tsai, E. Y. Chuang, T. P. Lu, and L. C. Lai. (2022). Lidocaine and Bupivacaine Downregulate MYB and DANCR lncRNA by Upregulating miR-187-5p in MCF-7 Cells. Frontiers in Medicine, 8:2969.
Y.C. Huang, T.C. Tsai, C.H. Chang, K.T. Chang, P.H. Ko, L. C. Lai, Indoxyl Sulfate Elevated Lnc-SLC15A1-1 Upregulating CXCL10/CXCL8 Expression in High-Glucose Endothelial Cells by Sponging MicroRNAs. Toxins. 13 (2021) 873.
Y.H. Lin, J.M. Chiou, T.F. Chen, L. C. Lai, J.H. Chen, Y.C. Chen, The association between metabolic syndrome and successful aging- using an extended definition of successful aging. PLoS One. 16 (2021) e0260550.
W. Fang, C.H. Wu, Q. Sun, Z.T. Gu, L. Zhu, T. Mao, X.F. Zhang, N. Xu, T.P. Lu, M.H. Tsai, L.H. Chen, L. C. Lai, E.Y. Chuang, Novel Tumor-Specific Antigens for Immunotherapy Identified from Multi-omics Profiling in Thymic Carcinomas. Front Immunol. 4804.
C.H. Lu, C.H. Wu, M.H. Tsai, L. C. Lai, E.Y. Chuang, MutScape: an analytical toolkit for probing the mutational landscape in cancer genomics. NAR genomics and bioinformatics. 3 (2021) lqab099.
Chen JH, Shih HS, Tu J, Chiou JM, Chang SH, Hsu WL, L. C. Lai, Chen TF, and Chen YC. A Longitudinal Study on the Association of Interrelated Factors Among Frailty Dimensions, Cognitive Domains, Cognitive Frailty, and All-Cause Mortality. JOURNAL OF ALZHEIMER'S DISEASE. 2021. Oct 29.
Yu LCH, Wei SC, Li YH, Lin PY, Chang XY, Weng JP, Shue YW, L. C. Lai, Wang JT, and Jeng YM. Invasive Pathobionts Contribute to Colon Cancer Initiation by Counterbalancing Epithelial Antimicrobial Responses. Cellular and Molecular Gastroenterology and Hepatology. 2021.
Lin YS, Kuo TT, Lo CC, Cheng WC, Chang WC, Tseng GC, Bai ST, Huang YK, Hsieh CY, Hsu HS, Jiang YF, Lin CY, L. C. Lai, Li XG, and Sher YP. ADAM9 functions as a transcriptional regulator to drive angiogenesis in esophageal squamous cell carcinoma. Int J Biol Sci. 2021. 17:3898-3910.
Wu CH, Hsieh CS, Chang YC, Huang CC, Yeh HT, Hou MF, Chung YC, Tu SH, Chang KJ, Chattopadhyay A, L. C. Lai, Lu TP, Li YH, Tsai MH, and Chuang EY. Differential whole-genome doubling and homologous recombination deficiencies across breast cancer subtypes from the Taiwanese population. Communication Biology. 2021. Sep 9; 4:1052.
Lee CY, Lee YF, L. C. Lai, Tsai MH, Lu TP, and Chuang EY. MiDSystem: A Comprehensive Online System for De Novo Assembly and Analysis of Microbial Genomes. New Biotechnology. 2021. 65:42-52.
Phan NN, Chattopadhyay A, Lee TT, Yin HI, Lu TP, L. C. Lai, Hwa HL, Tsai MH, and Chuang EY. High-performance deep learning pipeline predicts individuals in mixtures of DNA using sequencing data. Briefings in Bioinformatics. 2021. Aug 7.
Chattopadhyay A, Teoh ZH, Wu CY, Juang JJ, L. C. Lai, Tsai MH, Wu CH, Lu TP, and Chuang EY. CNVIntegrate: the first multi-ethnic database for identifying copy number variations associated with cancer. Database (Oxford). 2021. Jul 14; 2021.
Cheng YC, Su LY, Chen LH, Lu TP, Chuang EY, Tsai MH, Chuang LL, and L. C. Lai. Regulatory Mechanisms and Functional Roles of Hypoxia-Induced Long Non-Coding RNA MTORT1 in Breast Cancer Cells. Frontiers in Oncology. 2021. 11:663114.
Hung YM, Tsai MH, L. C. Lai, and Chuang EY. ATTRACTIVE – An Auto-Updating Database for Experimental Protocols in Regenerative Medicine. IEEE Access. 2021. 9:75202-75210.
Shih CH, Chuang LL, Tsai MH, Chen LH, Chuang EY, Lu TP, and L. C. Lai. Hypoxia-Induced MALAT1 Promotes the Proliferation and Migration of Breast Cancer Cells by Sponging MiR-3064-5p. Frontiers in Oncology. 2021. 11:658151.
Wu CH, Yeh HT, Hsieh CS, Huang CC, Chattopadhyay A, Chung YC, Tu SH, Li YH, Lu TP, L. C. Lai, Hou MF, Chang KJ, Tsai MH, and Chuang EY. Evolutionary Trajectories and Genomic Divergence in Localized Breast Cancers after Ipsilateral Breast Tumor Recurrence. Cancers (Basel). 2021. Apr 11; 13.
Chin WY, He CY, Chow TW, Yu QY, L. C. Lai, and Miaw SC. Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1alpha and AMPK in Macrophages. Frontiers in Immunology. 2021. 12:630318.
Hung YM, Lu TP, Tsai MH, L. C. Lai, and Chuang EY. EasyMAP: A user-friendly online platform for analyzing 16S ribosomal DNA sequencing data. New Biotechnology. 2021. Mar 9; 63:37-44.
Y.M. Hung, L. C. Lai, Factors to be considered in designing frameworks for automated bioinformatics pipelines—a perspective based on application setting. Transl Cancer Res. 9 (2020) 7382-7383.
H. C. Lo, J. H. Hsu, L. C. Lai, M. H. Tsai, and E. Y. Chuang. (2020, Sep 3). MicroRNA-107 enhances radiosensitivity by suppressing granulin in PC-3 prostate cancer cells. Scientific Reports, 10:14584.
Lin CC, Huang YK, Cho CF, Lin YS, Lo CC, Kuo TT, Tseng GC, Cheng WC, Chang WC, Hsiao TH, L. C. Lai, Shih JY, Liu YH, Chao KSC, Hsu JL, Lee PC, Sun X, Hung MC, and Sher YP. Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression. Theranostics. 2020. 10:10925-10939.
Chou YH, Pan SY, Shao YH, Shih HM, Wei SY, Lai CF, Chiang WC, Schrimpf C, Yang KC, L. C. Lai, Chen YM, Chu TS, and Lin SL. Methylation in pericytes after acute injury promotes chronic kidney disease. The Journal of Clinical Investigation. 2020. Aug 4; 10.1172/JCI135773.
Juang JJ, Binda A, Lee SJ, Hwang JJ, Chen WJ, Liu YB, Lin LY, Yu CC, Ho LT, Huang HC, Chen CJ, Lu TP, L. C. Lai, Yeh SS, Lai LP, Chuang EY, Rivolta I, and Antzelevitch C. GSTM3 variant is a novel genetic modifier in Brugada syndrome, a disease with risk of sudden cardiac death. EBioMedicine. 2020. Jul; 57:102843.
Huang YS, L. C. Lai, Chen YA, Lin KY, Chou YH, Chen HC, Wang SS, Wang JT, and Chang SC. Colonization with multidrug-resistant organisms among healthy adults in the community setting: prevalence, risk factors, and composition of gut microbiome. Frontiers in Microbiology. 2020. Jun 24; 11:1402.
Chen CH, Chen YF, Tsai PH, Chiou JM, L. C. Lai, Chen TF, Hung H, Chen JH, and Chen YC. Impacts of kidney dysfunction and cerebral cortical thinning on cognitive change in elderly population. Journal of Alzheimer's Disease. 2020. May 19.
Chao KH, Hsiao YW, Lee YF, Lee CY, L. C. Lai, Tsai MH, Lu TP, and Chuang EY. RNASeqR: an R package for automated two-group RNA-Seq analysis workflow. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2019. Dec 2.
W.C. Lin, L.H. Chen, Y.C. Hsieh, P.W. Yang, L. C. Lai, E.Y. Chuang, J.M. Lee, M.H. Tsai, miR-338-5p inhibits cell proliferation, colony formation, migration, and cisplatin resistance in esophageal squamous cancer cells by targeting FERMT2. Carcinogenesis. 40 (2019) 883-892.
Ko PH, Lenka G, Chen YA, Chuang EY, Tsai MH, Sher YP, and L. C. Lai. Semaphorin 5A suppresses the proliferation and migration of lung adenocarcinoma cells. International Journal of Oncology. 2019. Dec 2:10.3892/ijo.2019.4932.
Huang YC, and L. C. Lai. The potential roles of stem cell-derived extracellular vesicles as a therapeutic tool. Annals of Translational Medicine. 2019. Nov 10:10.21037/atm.2019.11.66.
Wang CH, Chang RW, Wu ET, Hsiao YJ, Wu MS, Yu HY, Chen YS, L. C. Lai, and Yu SL. Extracorporeal life support enhances the forward pressure wave to cause a mismatch between cardiac oxygen demand and supply. Scientific Reports. 2019. Sep 25; 9:13882.
Chen LH, Liao CY, L. C. Lai, Tsai MH, and Chuang EY. Semaphorin 6A attenuates the migration capability of lung cancer cells via the NRF2/HMOX1 axis. Scientific Reports. 2019. Sep 16; 9:13302.
L. C. Lai, Sun QL, Chen YA, Hsiao YW, Lu TP, Tsai MH, Zhu L, Chuang EY, and Fang W. Using proteomic profiling to characterize protein signatures of different thymoma subtypes. BMC Cancer. 2019. Aug 13; 19:796.
Wang TT, Lee CY, L. C. Lai, Tsai MH, Lu TP, and Chuang EY. anamiR: integrated analysis of MicroRNA and gene expression profiling. BMC Bioinformatics. 2019. May 14; 20:239.
Ko PH, Huang CW, Chang HH, Chuang EY, Tsai MH, and L. C. Lai. Identifying the functions and biomarkers of Codonopsis pilosula and Astragalus membranaceus aqueous extracts in hepatic cells. Chinese Medicine. 2019. Mar; 14:10.
Ko PH, Shen YC, Murugan K, Huang CW, Sivakumar G, Pal P, Liao CC, Luo KS, Chuang EY, Tsai MH, and L. C. Lai. Macrophage migration inhibitory factor acts as the potential target of a newly synthesized compound, 1-(9′-methyl-3′-carbazole)-3, 4-dihydro-β-carboline. Scientific Reports. 2019. Feb 14; 9:2147.
Lee CY, Chattopadhyay A, Chiang LM, Juang JJ, L. C. Lai, Tsai MH, Lu TP, and Chuang EY. VariED: the first integrated database of gene annotation and expression profiles for variants related to human diseases. Database (Oxford). 2019. Jan 1; 2019:10.1093/database/baz075.
Shen CY, Chang YC, Chen LH, Lin WC, Lee YH, Yeh ST, Chen HK, Fang W, Hsu CP, Lee JM, Lu TP, Hsiao PW, L. C. Lai, Tsai MH, and Chuang EY. The extracellular SEMA domain attenuates intracellular apoptotic signaling of semaphorin 6A in lung cancer cells. Oncogenesis. 2018. Dec 5; 7:95.
Yeh CC, Luo JL, Nhut Phan N, Cheng YC, Chow LP, Tsai MH, Chuang EY, and L. C. Lai. Different effects of long noncoding RNA NDRG1-OT1 fragments on NDRG1 transcription in breast cancer cells under hypoxia. RNA Biology. 2018. Nov 30.
Lee, C. Y., P. H. Hsieh, L. M. Chiang, A. Chattopadhyay, K. Y. Li, Y. F. Lee, T. P. Lu, L. C. Lai, E. C. Lin, H. Lee, S. T. Ding, M. H. Tsai, C. Y. Chen, and E. Y. Chuang. Whole-genome de novo sequencing reveals unique genes that contributed to the adaptive evolution of the Mikado pheasant. Gigascience. 2018. May 1; 7.
Tseng, T. C., D. Y. Huang, L. C. Lai, H. Hwai, Y. W. Hsiao, J. P. Jhou, E. Y. Chuang, and S. J. Tzeng. Dual immuno-renal targeting of 7-benzylidenenaltrexone alleviates lupus nephritis via FcgammaRIIB and HO-1. Journal of Molecular Medicine. 2018. Mar; 10.1007/s00109-018-1626-9.
Lin, H. C., C. C. Yeh, L. Y. Chao, M. H. Tsai, H. H. Chen, E. Y. Chuang, and L. C. Lai. The hypoxia-responsive lncRNA NDRG-OT1 promotes NDRG1 degradation via ubiquitin-mediated proteolysis in breast cancer cells. Oncotarget. 2018. Feb; 9:10470-10482.
Huang, S. H., Y. S. Chang, J. J. Juang, K. W. Chang, M. H. Tsai, T. P. Lu, L. C. Lai, E. Y. Chuang, and N. T. Huang. An automated microfluidic DNA microarray platform for genetic variant detection in inherited arrhythmic diseases. Analyst. 2018. Feb 9; 10.1039/c7an01648d.
Lee, Y. F., C. Y. Lee, L. C. Lai, M. H. Tsai, T. P. Lu, and E. Y. Chuang. CellExpress: a comprehensive microarray-based cancer cell line and clinical sample gene expression analysis online system. Database-the Journal of Biological Databases and Curation. 2018. Jan; 10.1093/database/bax101.
Chang, Y. Y., L. C. Lai, M. H. Tsai, and E. Y. Chuang. Deep sequencing reveals a microRNA expression signature in triple-negative breast cancer. Methods in Molecular Biology. 2018. 1699:99-111.
Wang, C. H., R. W. Chang, C. Y. Chang, M. S. Wu, H. L. Kao, L. C. Lai, T. H. Young, H. Y. Yu, Y. S. Chen, and K. C. Chang. Quantification of contractile mechanics in the rat heart from ventricular pressure alone. Oncotarget. 2017. Nov 10; 8:96161-96170.
Lin, C. Y., C. F. Cho, S. T. Bai, J. P. Liu, T. T. Kuo, L. J. Wang, Y. S. Lin, C. C. Lin, L. C. Lai, T. P. Lu, C. Y. Hsieh, C. N. Chu, D. C. Cheng, and Y. P. Sher. ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT. Scientific Reports. 2017. Nov; 7:15108.
Wei, S. C., H. F. Yang-Yen, P. N. Tsao, M. T. Weng, C. C. Tung, L. C. H. Yu, L. C. Lai, J. H. Hsiao, E. Y. Chuang, C. T. Shun, Y. H. Ni, R. J. Xavier, D. K. Podolsky, J. J. Y. Yen, and J. M. Wong. SHANK3 regulates intestinal barrier function through modulating ZO-1 expression through the PKCepsilon-dependent pathway. Inflammatory Bowel Diseases. 2017. Oct; 23:1730-1740.
Chiu, K. L., Y. S. Lin, T. T. Kuo, C. C. Lo, Y. K. Huang, H. F. Chang, E. Y. Chuang, C. C. Lin, W. C. Cheng, Y. N. Liu, L. C. Lai, and Y. P. Sher. ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis. Oncotarget. 2017. Jul; 8:47365-47378.
Chang, C. Y., R. W. Chang, S. H. Hsu, M. S. Wu, Y. J. Cheng, H. L. Kao, L. C. Lai, C. H. Wang, and K. C. Chang. Defects in vascular mechanics due to aging in rats: studies on arterial wave properties from a single aortic pressure pulse. Frontiers in Physiology. 2017. Jul; 8:503.
Lenka, G., M. H. Tsai, H. C. Lin, J. H. Hsiao, Y. C. Lee, T. P. Lu, J. M. Lee, C. P. Hsu, L. C. Lai, and E. Y. Chuang. Identification of methylation-driven, differentially expressed STXBP6 as a novel biomarker in lung adenocarcinoma. Scientific Reports. 2017. Feb; 7:42573.
Chang, R. W., C. Y. Chang, L. C. Lai, M. S. Wu, T. H. Young, Y. S. Chen, C. H. Wang, and K. C. Chang. Determining arterial wave transit time from a single aortic pressure pulse in rats: vascular impulse response analysis. Scientific Reports. 2017. Jan; 7:40998.
Lai, Y. P., L. B. Wang, W. A. Wang, L. C. Lai, M. H. Tsai, T. P. Lu, and E. Y. Chuang. iGC-an integrated analysis package of gene expression and copy number alteration. BMC Bioinformatics. 2017. Jan; 18:35.
Shen, C. Y., L. H. Chen, Y. F. Lin, L. C. Lai, E. Y. Chuang, and M. H. Tsai. Mitomycin C treatment induces resistance and enhanced migration via phosphorylated Akt in aggressive lung cancer cells. Oncotarget. 2016. Nov; 7:79995-80007.
Wang, W. A., L. C. Lai, M. H. Tsai, T. P. Lu, and E. Y. Chuang. Development of a prediction model for radiosensitivity using the expression values of genes and long non-coding RNAs. Oncotarget. 2016. May; 7:26739-50.
Lenka, G., M. H. Tsai, J. H. Hsiao, L. C. Lai, and E. Y. Chuang. Overexpression of methylation-driven DCC suppresses proliferation of lung cancer cells. Translational Cancer Research. 2016. Apr; 5:169-175.
Hsiao, T. H., Y. C. Chiu, P. Y. Hsu, T. P. Lu, L. C. Lai, M. H. Tsai, T. H. Huang, E. Y. Chuang, and Y. Chen. Differential network analysis reveals the genome-wide landscape of estrogen receptor modulation in hormonal cancers. Scientific Reports. 2016. Mar; 6:23035.
Chiu, Y. C., M. H. Tsai, W. C. Chou, Y. C. Liu, Y. Y. Kuo, H. A. Hou, T. P. Lu, L. C. Lai, Y. Chen, H. F. Tien, and E. Y. Chuang. Prognostic significance of NPM1 mutation-modulated microRNA-mRNA regulation in acute myeloid leukemia. Leukemia. 2016. Feb; 30:274-84.
Li, E. Y., W. Y. Huang, Y. C. Chang, M. H. Tsai, E. Y. Chuang, Q. Y. Kuok, S. T. Bai, L. Y. Chao, Y. P. Sher, and L. C. Lai. Aryl hydrocarbon receptor activates NDRG1 transcription under hypoxia in breast cancer cells. Scientific Reports. 2016. Feb; 6:20808.
Chang, R. W., C. Y. Chang, M. S. Wu, H. Y. Yu, J. M. Luo, Y. S. Chen, F. Y. Lin, L. C. Lai, C. H. Wang, and K. C. Chang. Systolic aortic pressure-time area is a useful index describing arterial wave properties in rats with diabetes. Scientific Reports. 2015. Dec; 5:17293.
Chiu, K. L., T. T. Kuo, Q. Y. Kuok, Y. S. Lin, C. H. Hua, C. Y. Lin, P. Y. Su, L. C. Lai, and Y. P. Sher. ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumor metastasis. Scientific Reports. 2015. Nov; 5:16426.
Woolston, A., N. Sintupisut, T. P. Lu, L. C. Lai, M. H. Tsai, E. Y. Chuang, and C. H. Yeang. Putative effectors for prognosis in lung adenocarcinoma are ethnic and gender specific. Oncotarget. 2015. Aug; 6:19483-99.
Kang, Y., Y. Y. Chang, Y. C. Liu, L. C. Lai, E. Y. Chuang, and M. H. Tsai. A microarray study of radiation-induced transcriptional responses and the role of Jagged 1 in two closely-related lung cancer cell lines. Translational Cancer Research. 2015. 4:314-323.
Lu, T. P., C. K. Hsiao, L. C. Lai, M. H. Tsai, C. P. Hsu, J. M. Lee, and E. Y. Chuang. Identification of regulatory SNPs associated with genetic modifications in lung adenocarcinoma. BMC Research Notes. 2015. Mar; 8:92.
Chang, Y. Y., W. H. Kuo, J. H. Hung, C. Y. Lee, Y. H. Lee, Y. C. Chang, W. C. Lin, C. Y. Shen, C. S. Huang, F. J. Hsieh, L. C. Lai, M. H. Tsai, K. J. Chang, and E. Y. Chuang. Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing. Molecular Cancer. 2015. Feb; 14:301.
Juang, J. M., T. P. Lu, L. C. Lai, C. C. Ho, Y. B. Liu, C. T. Tsai, L. Y. Lin, C. C. Yu, W. J. Chen, F. T. Chiang, S. F. Yeh, L. P. Lai, E. Y. Chuang, and J. L. Lin. Disease-targeted sequencing of ion channel genes identifies de novo mutations in patients with non-familial Brugada syndrome. Scientific Reports. 2014. Oct; 4:6733.
Huang, C. C., S. H. Tu, H. H. Lien, C. S. Huang, C. J. Huang, L. C. Lai, M. H. Tsai, and E. Y. Chuang. Refinement of breast cancer risk prediction with concordant leading edge subsets from prognostic gene signatures. Breast Cancer Research and Treatment. 2014. Sep; 147:353-70.
Lin, C. Y., H. J. Chen, C. C. Huang, L. C. Lai, T. P. Lu, G. C. Tseng, T. T. Kuo, Q. Y. Kuok, J. L. Hsu, S. Y. Sung, M. C. Hung, and Y. P. Sher. ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway. Cancer Research. 2014. Sep; 74:5229-43.
Lu, T. P., Y. Y. Hsu, L. C. Lai, M. H. Tsai, and E. Y. Chuang. Identification of gene expression biomarkers for predicting radiation exposure. Scientific Reports. 2014. Sep; 4:6293.
Luo, E. C., Y. C. Chang, Y. P. Sher, W. Y. Huang, L. L. Chuang, Y. C. Chiu, M. H. Tsai, E. Y. Chuang, and L. C. Lai. MicroRNA-769-3p down-regulates NDRG1 and enhances apoptosis in MCF-7 cells during reoxygenation. Scientific Reports. 2014. Aug; 4:5908.
Wei, S. C., Y. Y. Tan, M. T. Weng, L. C. Lai, J. H. Hsiao, E. Y. Chuang, C. T. Shun, D. C. Wu, A. W. Kao, C. S. Chuang, Y. H. Ni, M. J. Shieh, C. C. Tung, Y. Chen, C. Y. Wang, R. J. Xavier, D. K. Podolsky, and J. M. Wong. SLCO3A1, a novel Crohn's disease-associated gene, regulates NF-kappaB activity and associates with intestinal perforation. PLoS One. 2014. Jun; 9:e100515.
Sher, Y. P., L. J. Wang, L. L. Chuang, M. H. Tsai, T. T. Kuo, C. C. Huang, E. Y. Chuang, and L. C. Lai. ADAM9 up-regulates N-cadherin via miR-218 suppression in lung adenocarcinoma cells. PLoS One. 2014. Apr; 9:e94065.
L. C. Lai, M. H. Tsai, P. C. Chen, L. H. Chen, J. H. Hsiao, S. K. Chen, T. P. Lu, J. M. Lee, C. P. Hsu, C. K. Hsiao, and E. Y. Chuang. SNP rs10248565 in HDAC9 as a novel genomic aberration biomarker of lung adenocarcinoma in non-smoking women. Journal of Biomedical Science. 2014. Mar; 21:24.
Lu, T. P., K. T. Chen, M. H. Tsai, K. T. Kuo, C. K. Hsiao, L. C. Lai, and E. Y. Chuang. Identification of genes with consistent methylation levels across different human tissues. Scientific Reports. 2014. Mar; 4:4351.
Huang, C. C., S. H. Tu, H. H. Lien, J. Y. Jeng, J. S. Liu, C. S. Huang, L. C. Lai, and E. Y. Chuang. Estrogen receptor status prediction by gene component regression: a comparative study. International Journal of Data Mining and Bioinformatics. 2014. Feb; 9:149-71.
Juang, J. M., T. P. Lu, L. C. Lai, C. H. Hsueh, Y. B. Liu, C. T. Tsai, L. Y. Lin, C. C. Yu, J. J. Hwang, F. T. Chiang, S. S. Yeh, W. P. Chen, E. Y. Chuang, L. P. Lai, and J. L. Lin. Utilizing multiple in silico analyses to identify putative causal SCN5A variants in Brugada syndrome. Scientific Reports. 2014. Jan; 4:3850.
Huang, C. C., S. H. Tu, C. S. Huang, H. H. Lien, L. C. Lai, and E. Y. Chuang. Multiclass prediction with partial least square regression for gene expression data: applications in breast cancer intrinsic taxonomy. BioMed Research International. 2013. Nov; 2013:1-9.
Huang, C. C., S. H. Tu, H. H. Lien, J. Y. Jeng, C. S. Huang, C. J. Huang, L. C. Lai, and E. Y. Chuang. Concurrent gene signatures for Han Chinese breast cancers. PLoS One. 2013. Oct; 8:e76421.
Lai, T. Y., S. D. Wu, M. H. Tsai, E. Y. Chuang, L. L. Chuang, L. C. Hsu, and L. C. Lai. Transcription of Tnfaip3 is regulated by NF-kappaB and p38 via C/EBPbeta in activated macrophages. PLoS One. 2013. Sep; 8:e73153.
Chen, P. C., T. P. Lu, J. C. Chang,L. C. Lai, M. H. Tsai, C. K. Hsiao, and E. Y. Chuang. Concurrent analysis of copy number variation and gene expression: application in paired non-smoking female lung cancer patients. International Journal of Data Mining and Bioinformatics. 2013. Jul; 8:92-104.
Wu, F. C., L. C. Lai, Y. H. Kuo, Y. H. Lee, F. H. Hsu, C. Y. Shen, E. Y. Chuang, and M. H. Tsai. Differential genomic alterations in normal and cancerous lung cells in response to chronic inflammation. Translational Cancer Research. 2013. Apr; 2:64-73.
Liu, Y. J., Y. F. Lin, Y. F. Chen, E. C. Luo, Y. P. Sher, M. H. Tsai, E. Y. Chuang, and L. C. Lai. MicroRNA-449a enhances radiosensitivity in CL1-0 lung adenocarcinoma cells. PLoS One. 2013. Apr; 8:e62383.
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Kuo, W. H., Y. Y. Chang, L. C. Lai, M. H. Tsai, C. K. Hsiao, K. J. Chang, and E. Y. Chuang. Molecular characteristics and metastasis predictor genes of triple-negative breast cancer: a clinical study of triple-negative breast carcinomas. PLoS One. 2012. Sep; 7:e45831.
Lu, T. P., C. Y. Lee, M. H. Tsai, Y. C. Chiu, C. K. Hsiao, L. C. Lai, and E. Y. Chuang. miRSystem: An integrated system for characterizing enriched functions and pathways of microRNA targets. PLoS One. 2012. Aug; 7:e42390.
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Chen, S. Y., T. F. Chen, L. C. Lai, J. H. Chen, Y. Sun, L. L. Wen, P. K. Yip, Y. M. Chu, and Y. C. Chen. Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease. Journal of Neuroinflammation. 2012. Jan; 9:21.
Chen, Y. C., L. C. Lai, Y. P. Tu, S. D. Wu, C. F. Chen, and B. Li. Far infrared ray irradiation attenuates apoptosis and cell death of cultured keratinocytes stressed by dehydration. Journal of Photochemistry and Photobiology B: Biology. 2012. Jan; 106:61-8.
Cheng, H. C., Y. Sun, L. C. Lai, S. Y. Chen, W. C. Lee, J. H. Chen, T. F. Chen, H. H. Chen, L. L. Wen, P. K. Yip, Y. M. Chu, W. J. Chen, and Y. C. Chen. Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease. Journal of Negative Results in BioMedicine. 2012. Jan; 11:5.
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Chen, L. H., W. H. Kuo, M. H. Tsai, P. C. Chen, C. K. Hsiao, E. Y. Chuang, L. Y. Chang, F. J. Hsieh, L. C. Lai, and K. J. Chang. Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan. PLoS One. 2011. Nov; 6:e28222.
Hsu, F. H., H. I. Chen, M. H. Tsai, L. C. Lai, C. C. Huang, S. H. Tu, E. Y. Chuang, and Y. Chen. A model-based circular binary segmentation algorithm for the analysis of array CGH data. BMC Research Notes. 2011. Oct.; 4:394.
Lu, T. P., L. C. Lai, M. H. Tsai, P. C. Chen, C. P. Hsu, J. M. Lee, C. K. Hsiao, and E. Y. Chuang. Integrated analyses of copy number variations and gene expression in lung adenocarcinoma. PLoS One. 2011. Sep; 6:e24829.
L. C. Lai, Y. Y. Su, K. C. Chen, M. H. Tsai, Y. P. Sher, T. P. Lu, C. Y. Lee, and E. Y. Chuang. Down-regulation of NDRG1 promotes migration of cancer cells during reoxygenation. PLoS One. 2011. Aug; 6:e24375.
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L. C. Lai, M. T. Kissinger, P. V. Burke, and K. E. Kwast. Comparison of the transcriptomic "stress response" evoked by antimycin A and oxygen deprivation in Saccharomyces cerevisiae. BMC Genomics. 2008. Dec; 9:627.
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