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00:00
1.
index 1
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00:35
2.
Slide 2
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00:37
3.
Gastric Cancer
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01:01
4.
Risk factors of gastric cancer
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01:43
5.
RNA methylation (N6-methyladenosine modification, m6A)
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02:48
6.
Alteration of RNA m6A modification participates in the progression of gastric cancer
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03:57
7.
The relationship between demethylase and gastric cancer is still unclear……
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04:37
8.
Aims of the study
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04:54
9.
Slide 9
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04:57
10.
Methylated RNA immunoprecipitation sequencing of gastric cancer tissue
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05:31
11.
Workflow of meRIP-seq and data analysis
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06:14
12.
Methylated RNA immunoprecipitation sequencing of gastric cancer tissue
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06:45
13.
Methylated RNA immunoprecipitation sequencing of gastric cancer tissue
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07:55
14.
The expression level of ALKBH5 in gastric cancer tissues
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08:23
15.
The expression level of ALKBH5 in gastric cancer tissues
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09:04
16.
The functions of ALKBH5 in gastric cancer cells
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09:43
17.
The functions of ALKBH5 in gastric cancer cells
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11:10
18.
Summary-1
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11:34
19.
Investigate the downstream target of ALKBH5
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12:40
20.
Investigate the downstream target of ALKBH5
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13:04
21.
The role of PKMYT1
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13:05
22.
Investigate the downstream target of ALKBH5
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13:18
23.
The role of PKMYT1
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14:16
24.
The impact of PKMYT1 m6A modification
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15:01
25.
The impact of PKMYT1 m6A modification
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15:18
26.
The impact of PKMYT1 m6A modification
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15:55
27.
Summary-2
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16:13
28.
Results
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16:48
29.
Investigate the potential “reader” protein of PKMYT1
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17:22
30.
Investigate the potential “reader” protein of PKMYT1
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18:46
31.
Detect tumor lung metastasis in vivo
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19:21
32.
Results
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20:08
33.
Comments
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20:48
34.
Comments
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21:06
35.
Thank you
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21:15
36.
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