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00:00
1.
index 1
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00:03
2.
Slide 1
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00:11
3.
CircMET expression is significantly increased in NONO‑TFE3 tRCC
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05:24
4.
Characterization of CircMET in NONO‑TFE3 tRCC
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07:29
5.
CircMET is predominantly located in the cytosol
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10:04
6.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
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10:07
7.
CircMET is predominantly located in the cytosol
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11:02
8.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
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13:31
9.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
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14:57
10.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
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16:01
11.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
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16:02
12.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
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16:07
13.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
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16:11
14.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
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17:04
15.
Slide 8
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17:16
16.
NONO-TFE3 directly interacted with the promoter of MET
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38:14
17.
NONO-TFE3 promotes tumor progression by upregulating circMET
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38:19
18.
NONO-TFE3 directly interacted with the promoter of MET
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39:31
19.
NONO-TFE3 promotes tumor progression by upregulating circMET
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39:38
20.
Slide 11
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39:41
21.
CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
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1:02:10
22.
CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
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1:04:29
23.
CircMET
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1:04:29
24.
CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
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1:08:31
25.
CircMET
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1:08:39
26.
CircMET downregulates CDKN2A mRNA by direct binding
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1:08:41
27.
CircMET
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1:10:15
28.
CircMET downregulates CDKN2A mRNA by direct binding
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1:12:48
29.
CircMET downregulates CDKN2A mRNA by direct binding
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1:13:24
30.
CircMET accelerates the decay of CDKN2A mRNA by recruitment of YTHDF2
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1:18:28
31.
CircMET accelerates the decay of CDKN2A mRNA by recruitment of YTHDF2
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1:19:33
32.
Proliferation were inhibited by transfection with ΔYTHDF2 and gRNA-CDKN2A
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1:19:35
33.
Slide 20
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1:19:46
34.
CircMET functions as a ceRNA to sponge miR-1197
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1:20:53
35.
CircMET functions as a ceRNA to sponge miR-1197
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1:21:21
36.
CircMET functions as a ceRNA to sponge miR-1197
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1:21:28
37.
miR-1197 binds to 3’-UTR of SMAD3 mRNA
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1:22:16
38.
CircMET promotes SMAD3 expression through post‑transcriptional regulation
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1:22:20
39.
miR-1197 binds to 3’-UTR of SMAD3 mRNA
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1:23:11
40.
CircMET promotes SMAD3 expression through post‑transcriptional regulation
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1:24:07
41.
miR-1197 inhibits cell proliferation by downregulated SMAD3
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1:24:09
42.
Slide 27