• 00:00 1.
    index 1
  • 00:03 2.
    Slide 1
  • 00:11 3.
    CircMET expression is significantly increased in NONO‑TFE3 tRCC
  • 05:24 4.
    Characterization of CircMET in NONO‑TFE3 tRCC
  • 07:29 5.
    CircMET is predominantly located in the cytosol
  • 10:04 6.
    CircMET accelerates proliferation of NONO‑TFE3 tRCC
  • 10:07 7.
    CircMET is predominantly located in the cytosol
  • 11:02 8.
    CircMET accelerates proliferation of NONO‑TFE3 tRCC
  • 13:31 9.
    CircMET accelerates proliferation of NONO‑TFE3 tRCC
  • 14:57 10.
    CircMET accelerates proliferation of NONO‑TFE3 tRCC
  • 16:01 11.
    CircMET accelerates proliferation of NONO‑TFE3 tRCC
  • 16:02 12.
    CircMET accelerates proliferation of NONO‑TFE3 tRCC
  • 16:07 13.
    CircMET accelerates proliferation of NONO‑TFE3 tRCC
  • 16:11 14.
    CircMET accelerates proliferation of NONO‑TFE3 tRCC
  • 17:04 15.
    Slide 8
  • 17:16 16.
    NONO-TFE3 directly interacted with the promoter of MET
  • 38:14 17.
    NONO-TFE3 promotes tumor progression by upregulating circMET
  • 38:19 18.
    NONO-TFE3 directly interacted with the promoter of MET
  • 39:31 19.
    NONO-TFE3 promotes tumor progression by upregulating circMET
  • 39:38 20.
    Slide 11
  • 39:41 21.
    CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
  • 1:02:10 22.
    CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
  • 1:04:29 23.
    CircMET
  • 1:04:29 24.
    CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
  • 1:08:31 25.
    CircMET
  • 1:08:39 26.
    CircMET downregulates CDKN2A mRNA by direct binding
  • 1:08:41 27.
    CircMET
  • 1:10:15 28.
    CircMET downregulates CDKN2A mRNA by direct binding
  • 1:12:48 29.
    CircMET downregulates CDKN2A mRNA by direct binding
  • 1:13:24 30.
    CircMET accelerates the decay of CDKN2A mRNA by recruitment of YTHDF2
  • 1:18:28 31.
    CircMET accelerates the decay of CDKN2A mRNA by recruitment of YTHDF2
  • 1:19:33 32.
    Proliferation were inhibited by transfection with ΔYTHDF2 and gRNA-CDKN2A
  • 1:19:35 33.
    Slide 20
  • 1:19:46 34.
    CircMET functions as a ceRNA to sponge miR-1197
  • 1:20:53 35.
    CircMET functions as a ceRNA to sponge miR-1197
  • 1:21:21 36.
    CircMET functions as a ceRNA to sponge miR-1197
  • 1:21:28 37.
    miR-1197 binds to 3’-UTR of SMAD3 mRNA
  • 1:22:16 38.
    CircMET promotes SMAD3 expression through post‑transcriptional regulation
  • 1:22:20 39.
    miR-1197 binds to 3’-UTR of SMAD3 mRNA
  • 1:23:11 40.
    CircMET promotes SMAD3 expression through post‑transcriptional regulation
  • 1:24:07 41.
    miR-1197 inhibits cell proliferation by downregulated SMAD3
  • 1:24:09 42.
    Slide 27
  • Index
  • Notes
  • Comment
  • Fullscreen
20220321 lab meeting_家銘
Duration: 1:29:48, Browse: 299, Last Updated: 2022-03-29
    • 00:00 1.
      index 1
    • 00:03 2.
      Slide 1
    • 00:11 3.
      CircMET expression is significantly increased in NONO‑TFE3 tRCC
    • 05:24 4.
      Characterization of CircMET in NONO‑TFE3 tRCC
    • 07:29 5.
      CircMET is predominantly located in the cytosol
    • 10:04 6.
      CircMET accelerates proliferation of NONO‑TFE3 tRCC
    • 10:07 7.
      CircMET is predominantly located in the cytosol
    • 11:02 8.
      CircMET accelerates proliferation of NONO‑TFE3 tRCC
    • 13:31 9.
      CircMET accelerates proliferation of NONO‑TFE3 tRCC
    • 14:57 10.
      CircMET accelerates proliferation of NONO‑TFE3 tRCC
    • 16:01 11.
      CircMET accelerates proliferation of NONO‑TFE3 tRCC
    • 16:02 12.
      CircMET accelerates proliferation of NONO‑TFE3 tRCC
    • 16:07 13.
      CircMET accelerates proliferation of NONO‑TFE3 tRCC
    • 16:11 14.
      CircMET accelerates proliferation of NONO‑TFE3 tRCC
    • 17:04 15.
      Slide 8
    • 17:16 16.
      NONO-TFE3 directly interacted with the promoter of MET
    • 38:14 17.
      NONO-TFE3 promotes tumor progression by upregulating circMET
    • 38:19 18.
      NONO-TFE3 directly interacted with the promoter of MET
    • 39:31 19.
      NONO-TFE3 promotes tumor progression by upregulating circMET
    • 39:38 20.
      Slide 11
    • 39:41 21.
      CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
    • 1:02:10 22.
      CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
    • 1:04:29 23.
      CircMET
    • 1:04:29 24.
      CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
    • 1:08:31 25.
      CircMET
    • 1:08:39 26.
      CircMET downregulates CDKN2A mRNA by direct binding
    • 1:08:41 27.
      CircMET
    • 1:10:15 28.
      CircMET downregulates CDKN2A mRNA by direct binding
    • 1:12:48 29.
      CircMET downregulates CDKN2A mRNA by direct binding
    • 1:13:24 30.
      CircMET accelerates the decay of CDKN2A mRNA by recruitment of YTHDF2
    • 1:18:28 31.
      CircMET accelerates the decay of CDKN2A mRNA by recruitment of YTHDF2
    • 1:19:33 32.
      Proliferation were inhibited by transfection with ΔYTHDF2 and gRNA-CDKN2A
    • 1:19:35 33.
      Slide 20
    • 1:19:46 34.
      CircMET functions as a ceRNA to sponge miR-1197
    • 1:20:53 35.
      CircMET functions as a ceRNA to sponge miR-1197
    • 1:21:21 36.
      CircMET functions as a ceRNA to sponge miR-1197
    • 1:21:28 37.
      miR-1197 binds to 3’-UTR of SMAD3 mRNA
    • 1:22:16 38.
      CircMET promotes SMAD3 expression through post‑transcriptional regulation
    • 1:22:20 39.
      miR-1197 binds to 3’-UTR of SMAD3 mRNA
    • 1:23:11 40.
      CircMET promotes SMAD3 expression through post‑transcriptional regulation
    • 1:24:07 41.
      miR-1197 inhibits cell proliferation by downregulated SMAD3
    • 1:24:09 42.
      Slide 27
    Location
    Folder name
    2022
    Author
    柯怡君
    Branch
    賴亮全教授
    Created
    2022-03-21 11:00:50
    Last Updated
    2022-03-29 09:59:11
    Duration
    1:29:48