20220321 lab meeting_家銘 | 賴亮全實驗室

Index

00:00 1.
index 1
00:03 2.
Slide 1
00:11 3.
CircMET expression is significantly increased in NONO‑TFE3 tRCC
05:24 4.
Characterization of CircMET in NONO‑TFE3 tRCC
07:29 5.
CircMET is predominantly located in the cytosol
10:04 6.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
10:07 7.
CircMET is predominantly located in the cytosol
11:02 8.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
13:31 9.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
14:57 10.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
16:01 11.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
16:02 12.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
16:07 13.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
16:11 14.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
17:04 15.
Slide 8
17:16 16.
NONO-TFE3 directly interacted with the promoter of MET
38:14 17.
NONO-TFE3 promotes tumor progression by upregulating circMET
38:19 18.
NONO-TFE3 directly interacted with the promoter of MET
39:31 19.
NONO-TFE3 promotes tumor progression by upregulating circMET
39:38 20.
Slide 11
39:41 21.
CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
1:02:10 22.
CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
1:04:29 23.
CircMET
1:04:29 24.
CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
1:08:31 25.
CircMET
1:08:39 26.
CircMET downregulates CDKN2A mRNA by direct binding
1:08:41 27.
CircMET
1:10:15 28.
CircMET downregulates CDKN2A mRNA by direct binding
1:12:48 29.
CircMET downregulates CDKN2A mRNA by direct binding
1:13:24 30.
CircMET accelerates the decay of CDKN2A mRNA by recruitment of YTHDF2
1:18:28 31.
CircMET accelerates the decay of CDKN2A mRNA by recruitment of YTHDF2
1:19:33 32.
Proliferation were inhibited by transfection with ΔYTHDF2 and gRNA-CDKN2A
1:19:35 33.
Slide 20
1:19:46 34.
CircMET functions as a ceRNA to sponge miR-1197
1:20:53 35.
CircMET functions as a ceRNA to sponge miR-1197
1:21:21 36.
CircMET functions as a ceRNA to sponge miR-1197
1:21:28 37.
miR-1197 binds to 3’-UTR of SMAD3 mRNA
1:22:16 38.
CircMET promotes SMAD3 expression through post‑transcriptional regulation
1:22:20 39.
miR-1197 binds to 3’-UTR of SMAD3 mRNA
1:23:11 40.
CircMET promotes SMAD3 expression through post‑transcriptional regulation
1:24:07 41.
miR-1197 inhibits cell proliferation by downregulated SMAD3
1:24:09 42.
Slide 27

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Comment

00:00 1.
index 1
00:03 2.
Slide 1
00:11 3.
CircMET expression is significantly increased in NONO‑TFE3 tRCC
05:24 4.
Characterization of CircMET in NONO‑TFE3 tRCC
07:29 5.
CircMET is predominantly located in the cytosol
10:04 6.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
10:07 7.
CircMET is predominantly located in the cytosol
11:02 8.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
13:31 9.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
14:57 10.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
16:01 11.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
16:02 12.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
16:07 13.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
16:11 14.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
17:04 15.
Slide 8
17:16 16.
NONO-TFE3 directly interacted with the promoter of MET
38:14 17.
NONO-TFE3 promotes tumor progression by upregulating circMET
38:19 18.
NONO-TFE3 directly interacted with the promoter of MET
39:31 19.
NONO-TFE3 promotes tumor progression by upregulating circMET
39:38 20.
Slide 11
39:41 21.
CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
1:02:10 22.
CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
1:04:29 23.
CircMET
1:04:29 24.
CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
1:08:31 25.
CircMET
1:08:39 26.
CircMET downregulates CDKN2A mRNA by direct binding
1:08:41 27.
CircMET
1:10:15 28.
CircMET downregulates CDKN2A mRNA by direct binding
1:12:48 29.
CircMET downregulates CDKN2A mRNA by direct binding
1:13:24 30.
CircMET accelerates the decay of CDKN2A mRNA by recruitment of YTHDF2
1:18:28 31.
CircMET accelerates the decay of CDKN2A mRNA by recruitment of YTHDF2
1:19:33 32.
Proliferation were inhibited by transfection with ΔYTHDF2 and gRNA-CDKN2A
1:19:35 33.
Slide 20
1:19:46 34.
CircMET functions as a ceRNA to sponge miR-1197
1:20:53 35.
CircMET functions as a ceRNA to sponge miR-1197
1:21:21 36.
CircMET functions as a ceRNA to sponge miR-1197
1:21:28 37.
miR-1197 binds to 3’-UTR of SMAD3 mRNA
1:22:16 38.
CircMET promotes SMAD3 expression through post‑transcriptional regulation
1:22:20 39.
miR-1197 binds to 3’-UTR of SMAD3 mRNA
1:23:11 40.
CircMET promotes SMAD3 expression through post‑transcriptional regulation
1:24:07 41.
miR-1197 inhibits cell proliferation by downregulated SMAD3
1:24:09 42.
Slide 27

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20220321 lab meeting_家銘

Duration: 1:29:48, Browse: 373, Last Updated: 2022-03-29

Attachment(s):

20220321 lab meeting.pptx (9 MB)

00:00 1.
index 1
00:03 2.
Slide 1
00:11 3.
CircMET expression is significantly increased in NONO‑TFE3 tRCC
05:24 4.
Characterization of CircMET in NONO‑TFE3 tRCC
07:29 5.
CircMET is predominantly located in the cytosol
10:04 6.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
10:07 7.
CircMET is predominantly located in the cytosol
11:02 8.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
13:31 9.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
14:57 10.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
16:01 11.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
16:02 12.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
16:07 13.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
16:11 14.
CircMET accelerates proliferation of NONO‑TFE3 tRCC
17:04 15.
Slide 8
17:16 16.
NONO-TFE3 directly interacted with the promoter of MET
38:14 17.
NONO-TFE3 promotes tumor progression by upregulating circMET
38:19 18.
NONO-TFE3 directly interacted with the promoter of MET
39:31 19.
NONO-TFE3 promotes tumor progression by upregulating circMET
39:38 20.
Slide 11
39:41 21.
CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
1:02:10 22.
CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
1:04:29 23.
CircMET
1:04:29 24.
CircMET is exported to cytoplasm by YTHDC1 in m6A‑depend manner
1:08:31 25.
CircMET
1:08:39 26.
CircMET downregulates CDKN2A mRNA by direct binding
1:08:41 27.
CircMET
1:10:15 28.
CircMET downregulates CDKN2A mRNA by direct binding
1:12:48 29.
CircMET downregulates CDKN2A mRNA by direct binding
1:13:24 30.
CircMET accelerates the decay of CDKN2A mRNA by recruitment of YTHDF2
1:18:28 31.
CircMET accelerates the decay of CDKN2A mRNA by recruitment of YTHDF2
1:19:33 32.
Proliferation were inhibited by transfection with ΔYTHDF2 and gRNA-CDKN2A
1:19:35 33.
Slide 20
1:19:46 34.
CircMET functions as a ceRNA to sponge miR-1197
1:20:53 35.
CircMET functions as a ceRNA to sponge miR-1197
1:21:21 36.
CircMET functions as a ceRNA to sponge miR-1197
1:21:28 37.
miR-1197 binds to 3’-UTR of SMAD3 mRNA
1:22:16 38.
CircMET promotes SMAD3 expression through post‑transcriptional regulation
1:22:20 39.
miR-1197 binds to 3’-UTR of SMAD3 mRNA
1:23:11 40.
CircMET promotes SMAD3 expression through post‑transcriptional regulation
1:24:07 41.
miR-1197 inhibits cell proliferation by downregulated SMAD3
1:24:09 42.
Slide 27

Location

Folder name

2022

Author

柯怡君

Branch

賴亮全教授

Created

2022-03-21 11:00:50

Last Updated

2022-03-29 09:59:11

Duration

1:29:48