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00:00
1.
index 1
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00:02
2.
Slide 1
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00:30
3.
index 2
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00:58
4.
Breast Cancer
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01:40
5.
Triple-Negative Breast Cancer(TNBC)
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02:26
6.
Paclitaxel(PTX) is frequently used as the first-line treatment drug in BC.Chemoresistance is a major problem of cancer treatment associated with poor response.Mechanism of action of PTX
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03:05
7.
MicroRNA (miRNA)
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03:52
8.
Circular RNA (CircRNA)
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03:56
9.
MicroRNA (miRNA)
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04:21
10.
Circular RNA (CircRNA)
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05:00
11.
Functions of circRNA
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05:38
12.
PI3K/AKT pathway
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07:04
13.
The expression and prognostic significance of circWAC in TNBC
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15:51
14.
Features of circWAC
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32:28
15.
CircWAC was mainly distributed in the cytoplasm
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37:56
16.
CircWAC decrease chemosensitivity to PTX in TNBC
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37:57
17.
CircWAC was mainly distributed in the cytoplasm
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38:15
18.
CircWAC decrease chemosensitivity to PTX in TNBC
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38:18
19.
CircWAC was mainly distributed in the cytoplasm
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39:20
20.
CircWAC decrease chemosensitivity to PTX in TNBC
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44:15
21.
CircWAC decrease chemosensitivity to PTX in TNBC
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45:31
22.
CircWAC decrease chemosensitivity to PTX in TNBC
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54:14
23.
CircWAC acts as a sponge of miR-142 in TNBC
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54:15
24.
CircWAC decrease chemosensitivity to PTX in TNBC
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55:36
25.
CircWAC acts as a sponge of miR-142 in TNBC
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56:41
26.
CircWAC acts as a sponge of miR-142 in TNBC
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56:44
27.
CircWAC acts as a sponge of miR-142 in TNBC
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57:14
28.
CircWAC acts as a sponge of miR-142 in TNBC
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1:01:23
29.
CircWAC acts as a sponge of miR-142 in TNBC
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1:01:24
30.
CircWAC acts as a sponge of miR-142 in TNBC
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1:11:26
31.
CircWAC acts as a sponge of miR-142 in TNBC
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1:13:34
32.
CircWAC regulates PTX resistance by targeting miR-142
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1:19:54
33.
CircWAC regulates PTX resistance by targeting miR-142
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1:21:13
34.
WWP1 is the direct target gene of miR-142
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1:25:20
35.
WWP1 is the direct target gene of miR-142
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1:25:55
36.
WWP1 is the direct target gene of miR-142
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1:29:55
37.
The expression and prognostic significance of circWAC in TNBC
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1:30:41
38.
Inhibition of circWAC increases sensitivity to PTX in vivo
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1:39:58
39.
Conclusion
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1:43:26
40.
Inhibition of circWAC increases sensitivity to PTX in vivo