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00:00
1.
index 1
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00:26
2.
Slide 2
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01:29
3.
CircRNA expression profiles in NSCLC and characterization of circACVR2A
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02:28
4.
CircRNA expression profiles in NSCLC and characterization of circACVR2A
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03:02
5.
Slide 5
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03:05
6.
CircRNA expression profiles in NSCLC and characterization of circACVR2A
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03:24
7.
Slide 5
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04:15
8.
Slide 6
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04:54
9.
Slide 7
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06:01
10.
Slide 8
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06:34
11.
Prostate Cancer (PC)
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07:21
12.
Genetic Alterations and Treatment Approaches of PC
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08:08
13.
Mechanism of Androgen Receptor (AR)
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08:47
14.
Structure and Mechanism of Second-Generation Androgen Receptor Antagonists (SG-ARA)
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09:22
15.
Prostate Cancer Resistance Mechanisms
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10:05
16.
Heterogeneous Patterns of Resistance Mechanisms
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10:52
17.
Biological Functions of Long Non-coding RNA (lncRNA)
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11:35
18.
Slide 16
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12:12
19.
IRX4-AS1 Upregulated in Prostate Cancer
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13:30
20.
The Characteristic of IRX4-AS1
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14:37
21.
IRX4-AS1 had Lower Protein Coding Probability
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15:21
22.
Slide 20
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15:48
23.
Knockdown IRX4-AS1 Inhibit Cell Proliferation
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16:25
24.
Knockdown IRX4-AS1 Increased Cell Viability after SG-ARA Treatment
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17:01
25.
Slide 23
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17:31
26.
IRX4-AS1 has Binding Potential with AR
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18:12
27.
IRX4-AS1 didn’t bind with AR
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18:58
28.
IRX4-AS1 has Binding Potential with miRNA
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19:47
29.
Slide 27
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20:05
30.
Knockdown IRX4-AS1 Increased the Level of AR mRNA and AR Protein
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21:16
31.
Knockdown IRX4-AS1 Increased the Level of Canonical Gene
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21:58
32.
The Characteristic of C4-2 SG-ARA resistant
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23:18
33.
The Characteristic of C4-2 SG-ARA resistant
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23:34
34.
IRX4-AS1 downregulated in SG-ARA resistant cells
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24:10
35.
Slide 33
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24:28
36.
Slide 34
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25:47
37.
Thank you for listening
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26:12
38.
Slide 34
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26:45
39.
Genetic Alterations and Treatment Approaches of PC
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28:28
40.
Mechanism of Androgen Receptor (AR)
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28:31
41.
Prostate Cancer Resistance Mechanisms
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28:56
42.
Structure and Mechanism of Second-Generation Androgen Receptor Antagonists (SG-ARA)
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28:56
43.
Mechanism of Androgen Receptor (AR)
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28:56
44.
Genetic Alterations and Treatment Approaches of PC
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28:57
45.
Prostate Cancer (PC)
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28:57
46.
Slide 8
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28:58
47.
Slide 7
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29:00
48.
Slide 6
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29:06
49.
Slide 5
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29:20
50.
Slide 7
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30:30
51.
Knockdown IRX4-AS1 Increased the Level of Canonical Gene
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35:02
52.
IRX4-AS1 didn’t bind with AR
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36:24
53.
IRX4-AS1 downregulated in SG-ARA resistant cells
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38:23
54.
Slide 7
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39:08
55.
Prostate Cancer (PC)
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40:56
56.
** after 20240430_林俐妤seminar_V2-3.pptx