• 00:00 1.
    index 1
  • 00:23 2.
    Colorectal cancer
  • 01:01 3.
    Colorectal cancer low survival rate in stage 4
  • 01:33 4.
    Hypoxia in cancer
  • 02:22 5.
    CircRNA
  • 03:23 6.
    CircINSIG1 is upregulated by hypoxia in CRC
  • 05:23 7.
    Characterization of hypoxia-induced circINSIG1 in CRC
  • 08:14 8.
    High expression of circINSIG1 lower survival rate
  • 10:56 9.
    CircINSIG1 had protein coding potential in circRNADb prediction
  • 11:02 10.
    High expression of circINSIG1 lower survival rate
  • 11:59 11.
    CircINSIG1 had protein coding potential in circRNADb prediction
  • 27:31 12.
    CircINSIG1-121 were verified with specific amino acids
  • 30:00 13.
    CircINSIG1 had protein coding potential in circRNADb prediction
  • 30:11 14.
    CircINSIG1-121 were verified with specific amino acids
  • 32:46 15.
    High expression of circINSIG1-121 in CRC tumor tissue
  • 33:41 16.
    High expression of circINSIG1-121 lower survival rate
  • 35:20 17.
    CircINSIG1-121 promoted CRC growth in both HCT8 and DLD1
  • 38:56 18.
    CircINSIG1-121 promoted CRC progression
  • 40:22 19.
    CRC growth and metastasis were induced by circINSIG1-121
  • 41:22 20.
    CircINSIG1-121 downregulated INSIG1 protein expression
  • 41:50 21.
    CRC growth and metastasis were induced by circINSIG1-121
  • 41:51 22.
    CircINSIG1-121 promoted CRC progression
  • 41:52 23.
    CircINSIG1-121 promoted CRC growth in both HCT8 and DLD1
  • 41:56 24.
    CircINSIG1-121 promoted CRC progression
  • 41:56 25.
    CRC growth and metastasis were induced by circINSIG1-121
  • 41:57 26.
    CircINSIG1-121 downregulated INSIG1 protein expression
  • 42:40 27.
    CircINSIG1-121 induced cholesterol metabolism by INSIG1 ubiquitination
  • 42:53 28.
    CircINSIG1-121 downregulated INSIG1 protein expression
  • 44:05 29.
    CircINSIG1-121 induced cholesterol metabolism by INSIG1 ubiquitination
  • 51:46 30.
    SREBP2 target genes were induced by circINSIG1-121
  • 51:54 31.
    CircINSIG1-121 induced cholesterol metabolism by INSIG1 ubiquitination
  • 52:00 32.
    SREBP2 target genes were induced by circINSIG1-121
  • 52:23 33.
    INSIG1 were K48 ubiquitinated on K156/158 sites by circINSIG1-121
  • 52:49 34.
    ** after 20240226 meeting.pptx
  • 52:56 35.
    ubiquitination
  • 54:11 36.
    ** after 20240226 meeting.pptx
  • 54:22 37.
    INSIG1 were K48 ubiquitinated on K156/158 sites by circINSIG1-121
  • 54:23 38.
    ** after 20240226 meeting.pptx
  • 54:28 39.
    ubiquitination
  • 54:47 40.
    ** after 20240226 meeting.pptx
  • 54:55 41.
    INSIG1 were K48 ubiquitinated on K156/158 sites by circINSIG1-121
  • 57:54 42.
    INSIG1 were ubiquitinated on K156/158 by ASB6-CUL5
  • 1:04:00 43.
    ASB6 regulated INSIG1 stability and cholesterol metabolism in CRC
  • 1:06:01 44.
    ** after 20240226 meeting.pptx
  • 1:06:09 45.
    INSIG1 and SCAP
  • 1:07:10 46.
    ** after 20240226 meeting.pptx
  • 1:07:23 47.
    ASB6 regulated INSIG1 stability and cholesterol metabolism in CRC
  • 1:07:27 48.
    EIF4A3 interacted with circINSIG1 downstream through hypoxia
  • 1:09:39 49.
    EIF4A3 promoted circINSIG1 circulation by circINSIG1 downstream 1-6
  • 1:13:26 50.
    SREBP2 target genes were induced by EIF4A3
  • 1:13:49 51.
    CircINSIG1 induced PDX CRC progression
  • 1:15:40 52.
    CircINSIG1 induced SREBP2 target genes and cholesterol metabolism
  • 1:16:04 53.
    Conclusion
  • 1:17:11 54.
    Pros
  • 1:17:46 55.
    Slide 29
  • 1:17:51 56.
    Pros
  • 1:17:52 57.
    Conclusion
  • Index
  • Notes
  • Comment
  • Fullscreen
20240226 lab meeting_楷軒
Duration: 1:18:21, Browse: 81, Last Updated: 2024-02-26
    • 00:00 1.
      index 1
    • 00:23 2.
      Colorectal cancer
    • 01:01 3.
      Colorectal cancer low survival rate in stage 4
    • 01:33 4.
      Hypoxia in cancer
    • 02:22 5.
      CircRNA
    • 03:23 6.
      CircINSIG1 is upregulated by hypoxia in CRC
    • 05:23 7.
      Characterization of hypoxia-induced circINSIG1 in CRC
    • 08:14 8.
      High expression of circINSIG1 lower survival rate
    • 10:56 9.
      CircINSIG1 had protein coding potential in circRNADb prediction
    • 11:02 10.
      High expression of circINSIG1 lower survival rate
    • 11:59 11.
      CircINSIG1 had protein coding potential in circRNADb prediction
    • 27:31 12.
      CircINSIG1-121 were verified with specific amino acids
    • 30:00 13.
      CircINSIG1 had protein coding potential in circRNADb prediction
    • 30:11 14.
      CircINSIG1-121 were verified with specific amino acids
    • 32:46 15.
      High expression of circINSIG1-121 in CRC tumor tissue
    • 33:41 16.
      High expression of circINSIG1-121 lower survival rate
    • 35:20 17.
      CircINSIG1-121 promoted CRC growth in both HCT8 and DLD1
    • 38:56 18.
      CircINSIG1-121 promoted CRC progression
    • 40:22 19.
      CRC growth and metastasis were induced by circINSIG1-121
    • 41:22 20.
      CircINSIG1-121 downregulated INSIG1 protein expression
    • 41:50 21.
      CRC growth and metastasis were induced by circINSIG1-121
    • 41:51 22.
      CircINSIG1-121 promoted CRC progression
    • 41:52 23.
      CircINSIG1-121 promoted CRC growth in both HCT8 and DLD1
    • 41:56 24.
      CircINSIG1-121 promoted CRC progression
    • 41:56 25.
      CRC growth and metastasis were induced by circINSIG1-121
    • 41:57 26.
      CircINSIG1-121 downregulated INSIG1 protein expression
    • 42:40 27.
      CircINSIG1-121 induced cholesterol metabolism by INSIG1 ubiquitination
    • 42:53 28.
      CircINSIG1-121 downregulated INSIG1 protein expression
    • 44:05 29.
      CircINSIG1-121 induced cholesterol metabolism by INSIG1 ubiquitination
    • 51:46 30.
      SREBP2 target genes were induced by circINSIG1-121
    • 51:54 31.
      CircINSIG1-121 induced cholesterol metabolism by INSIG1 ubiquitination
    • 52:00 32.
      SREBP2 target genes were induced by circINSIG1-121
    • 52:23 33.
      INSIG1 were K48 ubiquitinated on K156/158 sites by circINSIG1-121
    • 52:49 34.
      ** after 20240226 meeting.pptx
    • 52:56 35.
      ubiquitination
    • 54:11 36.
      ** after 20240226 meeting.pptx
    • 54:22 37.
      INSIG1 were K48 ubiquitinated on K156/158 sites by circINSIG1-121
    • 54:23 38.
      ** after 20240226 meeting.pptx
    • 54:28 39.
      ubiquitination
    • 54:47 40.
      ** after 20240226 meeting.pptx
    • 54:55 41.
      INSIG1 were K48 ubiquitinated on K156/158 sites by circINSIG1-121
    • 57:54 42.
      INSIG1 were ubiquitinated on K156/158 by ASB6-CUL5
    • 1:04:00 43.
      ASB6 regulated INSIG1 stability and cholesterol metabolism in CRC
    • 1:06:01 44.
      ** after 20240226 meeting.pptx
    • 1:06:09 45.
      INSIG1 and SCAP
    • 1:07:10 46.
      ** after 20240226 meeting.pptx
    • 1:07:23 47.
      ASB6 regulated INSIG1 stability and cholesterol metabolism in CRC
    • 1:07:27 48.
      EIF4A3 interacted with circINSIG1 downstream through hypoxia
    • 1:09:39 49.
      EIF4A3 promoted circINSIG1 circulation by circINSIG1 downstream 1-6
    • 1:13:26 50.
      SREBP2 target genes were induced by EIF4A3
    • 1:13:49 51.
      CircINSIG1 induced PDX CRC progression
    • 1:15:40 52.
      CircINSIG1 induced SREBP2 target genes and cholesterol metabolism
    • 1:16:04 53.
      Conclusion
    • 1:17:11 54.
      Pros
    • 1:17:46 55.
      Slide 29
    • 1:17:51 56.
      Pros
    • 1:17:52 57.
      Conclusion
    Location
    Folder name
    2024
    Author
    朱庭汶
    Branch
    賴亮全教授
    Created
    2024-02-26 14:31:38
    Last Updated
    2024-02-26 15:00:29
    Duration
    1:18:21