• 00:00 1.
    index 1
  • 00:27 2.
    METTL1-mediated m7G modification promotes lenvatinib resistance in HCC
  • 01:03 3.
    m7G function
  • 01:05 4.
    METTL1-mediated m7G modification promotes lenvatinib resistance in HCC
  • 03:11 5.
    m7G function
  • 06:39 6.
    TRAC-seq
  • 09:33 7.
    Screening of regulatory factors for Lenvatinib resistance
  • 13:54 8.
    Screening of regulatory factors for Lenvatinib resistance
  • 26:37 9.
    METTL1-induced tRNA m7G modification regulates the Lenvatinib sensitivity
  • 40:51 10.
    METTL1-induced tRNA m7G modification regulates the Lenvatinib sensitivity
  • 50:53 11.
    m7G tRNA modification upregulates translation activity in LR cells
  • 52:27 12.
    ** after 20241028 lab meeting.pptx
  • 52:33 13.
    Puromycin
  • 52:46 14.
    Puromycin
  • 53:28 15.
    ** after 20241028 lab meeting.pptx
  • 53:42 16.
    m7G tRNA modification upregulates translation activity in LR cells
  • 58:52 17.
    m7G tRNA modification upregulates translation activity in LR cells
  • 1:02:33 18.
    m7G tRNA modification sustains LR by EGFR translation
  • 1:08:37 19.
    m7G tRNA modification sustains LR by EGFR translation
  • 1:11:04 20.
    m7G tRNA modification sustains LR by EGFR translation
  • 1:18:18 21.
    EGFR is a key METTL1 target that mediates LR in HCC
  • 1:18:18 22.
    m7G tRNA modification sustains LR by EGFR translation
  • 1:18:21 23.
    EGFR is a key METTL1 target that mediates LR in HCC
  • 1:19:05 24.
    EGFR is a key METTL1 target that mediates LR in HCC
  • 1:19:26 25.
    METTL1 promotes lenvatinib resistance in vivo
  • 1:25:00 26.
    METTL1 promotes lenvatinib resistance in vivo
  • 1:26:27 27.
    Targeting METTL1 effectively retards LR in vivo
  • 1:30:41 28.
    Targeting METTL1 effectively retards LR in vivo
  • 1:30:57 29.
    Targeting METTL1 effectively retards LR in vivo
  • 1:31:01 30.
    Targeting METTL1 effectively retards LR in vivo
  • 1:32:35 31.
    Slide 20
  • 1:32:36 32.
    Targeting METTL1 effectively retards LR in vivo
  • 1:32:50 33.
    20241028 lab meeting 楷軒.pptx
  • Index
  • Notes
  • Comment
  • Fullscreen
20241028 lab meeting_楷軒
Duration: 1:33:06, Browse: 43, Last Updated: 2024-10-28
    • 00:00 1.
      index 1
    • 00:27 2.
      METTL1-mediated m7G modification promotes lenvatinib resistance in HCC
    • 01:03 3.
      m7G function
    • 01:05 4.
      METTL1-mediated m7G modification promotes lenvatinib resistance in HCC
    • 03:11 5.
      m7G function
    • 06:39 6.
      TRAC-seq
    • 09:33 7.
      Screening of regulatory factors for Lenvatinib resistance
    • 13:54 8.
      Screening of regulatory factors for Lenvatinib resistance
    • 26:37 9.
      METTL1-induced tRNA m7G modification regulates the Lenvatinib sensitivity
    • 40:51 10.
      METTL1-induced tRNA m7G modification regulates the Lenvatinib sensitivity
    • 50:53 11.
      m7G tRNA modification upregulates translation activity in LR cells
    • 52:27 12.
      ** after 20241028 lab meeting.pptx
    • 52:33 13.
      Puromycin
    • 52:46 14.
      Puromycin
    • 53:28 15.
      ** after 20241028 lab meeting.pptx
    • 53:42 16.
      m7G tRNA modification upregulates translation activity in LR cells
    • 58:52 17.
      m7G tRNA modification upregulates translation activity in LR cells
    • 1:02:33 18.
      m7G tRNA modification sustains LR by EGFR translation
    • 1:08:37 19.
      m7G tRNA modification sustains LR by EGFR translation
    • 1:11:04 20.
      m7G tRNA modification sustains LR by EGFR translation
    • 1:18:18 21.
      EGFR is a key METTL1 target that mediates LR in HCC
    • 1:18:18 22.
      m7G tRNA modification sustains LR by EGFR translation
    • 1:18:21 23.
      EGFR is a key METTL1 target that mediates LR in HCC
    • 1:19:05 24.
      EGFR is a key METTL1 target that mediates LR in HCC
    • 1:19:26 25.
      METTL1 promotes lenvatinib resistance in vivo
    • 1:25:00 26.
      METTL1 promotes lenvatinib resistance in vivo
    • 1:26:27 27.
      Targeting METTL1 effectively retards LR in vivo
    • 1:30:41 28.
      Targeting METTL1 effectively retards LR in vivo
    • 1:30:57 29.
      Targeting METTL1 effectively retards LR in vivo
    • 1:31:01 30.
      Targeting METTL1 effectively retards LR in vivo
    • 1:32:35 31.
      Slide 20
    • 1:32:36 32.
      Targeting METTL1 effectively retards LR in vivo
    • 1:32:50 33.
      20241028 lab meeting 楷軒.pptx
    Location
    Folder name
    2024
    Author
    黃鈺涵
    Branch
    賴亮全教授
    Created
    2024-10-28 10:50:36
    Last Updated
    2024-10-28 11:21:33
    Duration
    1:33:06