• 00:00 1.
    index 1
  • 00:29 2.
    Slide 1
  • 00:33 3.
    RNA methylation (m6A)
  • 00:42 4.
    Slide 1
  • 01:06 5.
    RNA methylation (m6A)
  • 01:49 6.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 01:50 7.
    RNA methylation (m6A)
  • 02:34 8.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 08:22 9.
    m6A motif
  • 08:51 10.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 11:04 11.
    m6A motif
  • 13:07 12.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 13:26 13.
    m6A motif
  • 13:27 14.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 13:27 15.
    m6A motif
  • 13:28 16.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 15:15 17.
    m6A motif
  • 15:16 18.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 15:17 19.
    m6A motif
  • 15:17 20.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 15:49 21.
    m6A motif
  • 15:50 22.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 19:54 23.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 24:56 24.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 25:06 25.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 26:02 26.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 26:36 27.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 28:14 28.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 30:12 29.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 37:56 30.
    Summary 1To assess overall levels of m6A modification in gastric cancer……
  • 37:58 31.
    Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
  • 38:26 32.
    Summary 1To assess overall levels of m6A modification in gastric cancer……
  • 39:30 33.
    Fig. 2 ALKBH5 inhibits cell invasion in vitro
  • 41:24 34.
    Fig. 2 ALKBH5 inhibits cell invasion in vitro
  • 41:26 35.
    Fig. 2 ALKBH5 inhibits cell invasion in vitro
  • 43:05 36.
    Fig. 2 ALKBH5 inhibits cell invasion in vitro
  • 43:50 37.
    Fig. 2 ALKBH5 inhibits cell invasion in vitro
  • 48:46 38.
    S2
  • 49:30 39.
    Slide 14
  • 49:35 40.
    RNA-seq
  • 49:54 41.
    Slide 14
  • 49:54 42.
    S2
  • 49:55 43.
    Fig. 2 ALKBH5 inhibits cell invasion in vitro
  • 49:55 44.
    Fig. 2 ALKBH5 inhibits cell invasion in vitro
  • 49:55 45.
    Fig. 2 ALKBH5 inhibits cell invasion in vitro
  • 49:59 46.
    Fig. 2 ALKBH5 inhibits cell invasion in vitro
  • 49:59 47.
    Fig. 2 ALKBH5 inhibits cell invasion in vitro
  • 49:59 48.
    S2
  • 50:00 49.
    Slide 14
  • 50:28 50.
    RNA-seq
  • 51:31 51.
    Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
  • 51:34 52.
    RNA-seq
  • 58:33 53.
    Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
  • 1:00:10 54.
    Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
  • 1:01:52 55.
    Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
  • 1:04:17 56.
    Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
  • 1:04:20 57.
    Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
  • 1:04:34 58.
    Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
  • 1:11:33 59.
    Slide 20
  • 1:11:34 60.
    Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
  • 1:12:03 61.
    Slide 20
  • 1:12:24 62.
    Fig. 4 ALKBH5 regulates PKMYT1 via its m6A-dependent manner
  • 1:15:12 63.
    Fig. 4 ALKBH5 regulates PKMYT1 via its m6A-dependent manner
  • 1:17:57 64.
    Fig. 4 ALKBH5 regulates PKMYT1 via its m6A-dependent manner
  • 1:17:58 65.
    Fig. 4 ALKBH5 regulates PKMYT1 via its m6A-dependent manner
  • 1:24:29 66.
    Fig. 4 ALKBH5 regulates PKMYT1 via its m6A-dependent manner
  • 1:26:22 67.
    Slide 24
  • 1:26:38 68.
    Fig. 5 ALKBH5 and IGF2BP3 together regulates the expression of PKMYT1 via its m6A modification
  • 1:28:36 69.
    Fig. 5 ALKBH5 and IGF2BP3 together regulates the expression of PKMYT1 via its m6A modification
  • 1:29:17 70.
    Fig. 5 ALKBH5 and IGF2BP3 together regulates the expression of PKMYT1 via its m6A modification
  • 1:30:44 71.
    Fig. 5 ALKBH5 and IGF2BP3 together regulates the expression of PKMYT1 via its m6A modification
  • 1:33:17 72.
    Fig. 5 ALKBH5 and IGF2BP3 together regulates the expression of PKMYT1 via its m6A modification
  • 1:34:19 73.
    Summary 5investigate the potential “reader” in m6A modification of PKMYT1 ……
  • 1:34:22 74.
    Fig. 6 ALKBH5-PKMYT1-IGF2BP3 axis inhibits invasion and migration in vivo
  • 1:36:24 75.
    Fig. 6 ALKBH5-PKMYT1-IGF2BP3 axis inhibits invasion and migration in vivo
  • 1:36:58 76.
    Fig. 6 ALKBH5-PKMYT1-IGF2BP3 axis inhibits invasion and migration in vivo
  • 1:37:00 77.
    Fig. 6 ALKBH5-PKMYT1-IGF2BP3 axis inhibits invasion and migration in vivo
  • 1:37:05 78.
    Fig. 6 ALKBH5-PKMYT1-IGF2BP3 axis inhibits invasion and migration in vivo
  • 1:38:22 79.
    Slide 34
  • 1:39:41 80.
    ** after 20220307_逸安 (Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modifcation).pptx
  • Index
  • Notes
  • Comment
  • Fullscreen
20220307 lab meeting_逸安
Duration: 1:43:32, Browse: 205, Last Updated: 2022-03-29
    • 00:00 1.
      index 1
    • 00:29 2.
      Slide 1
    • 00:33 3.
      RNA methylation (m6A)
    • 00:42 4.
      Slide 1
    • 01:06 5.
      RNA methylation (m6A)
    • 01:49 6.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 01:50 7.
      RNA methylation (m6A)
    • 02:34 8.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 08:22 9.
      m6A motif
    • 08:51 10.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 11:04 11.
      m6A motif
    • 13:07 12.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 13:26 13.
      m6A motif
    • 13:27 14.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 13:27 15.
      m6A motif
    • 13:28 16.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 15:15 17.
      m6A motif
    • 15:16 18.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 15:17 19.
      m6A motif
    • 15:17 20.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 15:49 21.
      m6A motif
    • 15:50 22.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 19:54 23.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 24:56 24.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 25:06 25.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 26:02 26.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 26:36 27.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 28:14 28.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 30:12 29.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 37:56 30.
      Summary 1To assess overall levels of m6A modification in gastric cancer……
    • 37:58 31.
      Fig. 1 MeRIP-seq reveals correlation between m6A and cell adhesion, and ALKBH5 is associated with GC prognosis
    • 38:26 32.
      Summary 1To assess overall levels of m6A modification in gastric cancer……
    • 39:30 33.
      Fig. 2 ALKBH5 inhibits cell invasion in vitro
    • 41:24 34.
      Fig. 2 ALKBH5 inhibits cell invasion in vitro
    • 41:26 35.
      Fig. 2 ALKBH5 inhibits cell invasion in vitro
    • 43:05 36.
      Fig. 2 ALKBH5 inhibits cell invasion in vitro
    • 43:50 37.
      Fig. 2 ALKBH5 inhibits cell invasion in vitro
    • 48:46 38.
      S2
    • 49:30 39.
      Slide 14
    • 49:35 40.
      RNA-seq
    • 49:54 41.
      Slide 14
    • 49:54 42.
      S2
    • 49:55 43.
      Fig. 2 ALKBH5 inhibits cell invasion in vitro
    • 49:55 44.
      Fig. 2 ALKBH5 inhibits cell invasion in vitro
    • 49:55 45.
      Fig. 2 ALKBH5 inhibits cell invasion in vitro
    • 49:59 46.
      Fig. 2 ALKBH5 inhibits cell invasion in vitro
    • 49:59 47.
      Fig. 2 ALKBH5 inhibits cell invasion in vitro
    • 49:59 48.
      S2
    • 50:00 49.
      Slide 14
    • 50:28 50.
      RNA-seq
    • 51:31 51.
      Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
    • 51:34 52.
      RNA-seq
    • 58:33 53.
      Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
    • 1:00:10 54.
      Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
    • 1:01:52 55.
      Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
    • 1:04:17 56.
      Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
    • 1:04:20 57.
      Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
    • 1:04:34 58.
      Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
    • 1:11:33 59.
      Slide 20
    • 1:11:34 60.
      Fig. 3 PKMYT1 was identified as a downstream target of ALKBH5
    • 1:12:03 61.
      Slide 20
    • 1:12:24 62.
      Fig. 4 ALKBH5 regulates PKMYT1 via its m6A-dependent manner
    • 1:15:12 63.
      Fig. 4 ALKBH5 regulates PKMYT1 via its m6A-dependent manner
    • 1:17:57 64.
      Fig. 4 ALKBH5 regulates PKMYT1 via its m6A-dependent manner
    • 1:17:58 65.
      Fig. 4 ALKBH5 regulates PKMYT1 via its m6A-dependent manner
    • 1:24:29 66.
      Fig. 4 ALKBH5 regulates PKMYT1 via its m6A-dependent manner
    • 1:26:22 67.
      Slide 24
    • 1:26:38 68.
      Fig. 5 ALKBH5 and IGF2BP3 together regulates the expression of PKMYT1 via its m6A modification
    • 1:28:36 69.
      Fig. 5 ALKBH5 and IGF2BP3 together regulates the expression of PKMYT1 via its m6A modification
    • 1:29:17 70.
      Fig. 5 ALKBH5 and IGF2BP3 together regulates the expression of PKMYT1 via its m6A modification
    • 1:30:44 71.
      Fig. 5 ALKBH5 and IGF2BP3 together regulates the expression of PKMYT1 via its m6A modification
    • 1:33:17 72.
      Fig. 5 ALKBH5 and IGF2BP3 together regulates the expression of PKMYT1 via its m6A modification
    • 1:34:19 73.
      Summary 5investigate the potential “reader” in m6A modification of PKMYT1 ……
    • 1:34:22 74.
      Fig. 6 ALKBH5-PKMYT1-IGF2BP3 axis inhibits invasion and migration in vivo
    • 1:36:24 75.
      Fig. 6 ALKBH5-PKMYT1-IGF2BP3 axis inhibits invasion and migration in vivo
    • 1:36:58 76.
      Fig. 6 ALKBH5-PKMYT1-IGF2BP3 axis inhibits invasion and migration in vivo
    • 1:37:00 77.
      Fig. 6 ALKBH5-PKMYT1-IGF2BP3 axis inhibits invasion and migration in vivo
    • 1:37:05 78.
      Fig. 6 ALKBH5-PKMYT1-IGF2BP3 axis inhibits invasion and migration in vivo
    • 1:38:22 79.
      Slide 34
    • 1:39:41 80.
      ** after 20220307_逸安 (Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modifcation).pptx
    Location
    Folder name
    2022
    Author
    柯怡君
    Branch
    賴亮全教授
    Created
    2022-03-07 11:05:58
    Last Updated
    2022-03-29 09:58:21
    Duration
    1:43:32