• 00:00 1.
    index 1
  • 00:21 2.
    Metabolic heterogeneity in lung tumors
  • 01:08 3.
    LncRNA ADPGK-AS1 was upregulated in TAMs
  • 04:10 4.
    LncRNA ADPGK-AS1 was upregulated in TAMs in association with mitochondria
  • 04:12 5.
    LncRNA ADPGK-AS1 was upregulated in TAMs
  • 05:40 6.
    LncRNA ADPGK-AS1 was upregulated in TAMs in association with mitochondria
  • 11:50 7.
    MRPL35 was abundant in M2-like TAMs
  • 18:52 8.
    ADPGK-AS1 overexpression altered the regulation of mitochondrial metabolism
  • 23:32 9.
    ADPGK-AS1 overexpression altered the regulation of mitochondrial metabolism
  • 25:12 10.
    ADPGK-AS1 overexpression altered the regulation of mitochondrial metabolism
  • 25:13 11.
    ADPGK-AS1 overexpression increased levels of TCA cycle metabolites
  • 25:13 12.
    ADPGK-AS1 overexpression decreased ROS levels
  • 25:14 13.
    Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
  • 25:14 14.
    Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
  • 25:15 15.
    ADPGK-AS1 overexpression in macrophages induced a tumor-promoting M2-like phenotype
  • 25:15 16.
    ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
  • 25:16 17.
    ADPGK-AS1 knockdown inhibited tumor growth in vivo
  • 25:16 18.
    ADPGK-AS1 knockdown inhibited tumor growth in vivo
  • 25:16 19.
    ADPGK-AS1 influenced human lung tumor progression ex vivo
  • 25:17 20.
    CircZFR modulated MYO1B splicing
  • 25:17 21.
    Slide 19
  • 25:17 22.
    Thank you for listening
  • 25:18 23.
    RNA therapy
  • 25:18 24.
    Oxygen consumption rate (OCR)
  • 28:58 25.
    RNA therapy
  • 28:59 26.
    Thank you for listening
  • 28:59 27.
    Slide 19
  • 28:59 28.
    CircZFR modulated MYO1B splicing
  • 29:00 29.
    ADPGK-AS1 influenced human lung tumor progression ex vivo
  • 29:00 30.
    ADPGK-AS1 knockdown inhibited tumor growth in vivo
  • 29:01 31.
    ADPGK-AS1 knockdown inhibited tumor growth in vivo
  • 29:01 32.
    ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
  • 29:02 33.
    ADPGK-AS1 overexpression in macrophages induced a tumor-promoting M2-like phenotype
  • 29:03 34.
    Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
  • 29:03 35.
    Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
  • 29:04 36.
    ADPGK-AS1 overexpression decreased ROS levels
  • 29:05 37.
    ADPGK-AS1 overexpression increased levels of TCA cycle metabolites
  • 29:05 38.
    ADPGK-AS1 overexpression altered the regulation of mitochondrial metabolism
  • 29:06 39.
    ADPGK-AS1 overexpression altered the regulation of mitochondrial metabolism
  • 29:08 40.
    ADPGK-AS1 overexpression altered the regulation of mitochondrial metabolism
  • 30:20 41.
    ADPGK-AS1 overexpression increased levels of TCA cycle metabolites
  • 36:55 42.
    ADPGK-AS1 overexpression decreased ROS levels
  • 38:57 43.
    Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
  • 39:00 44.
    ADPGK-AS1 overexpression decreased ROS levels
  • 39:07 45.
    Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
  • 41:32 46.
    Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
  • 41:37 47.
    Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
  • 41:38 48.
    Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
  • 45:33 49.
    ADPGK-AS1 overexpression in macrophages induced a tumor-promoting M2-like phenotype
  • 49:03 50.
    ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
  • 50:11 51.
    ADPGK-AS1 knockdown inhibited tumor growth in vivo
  • 50:13 52.
    ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
  • 50:14 53.
    ADPGK-AS1 overexpression in macrophages induced a tumor-promoting M2-like phenotype
  • 50:33 54.
    ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
  • 50:33 55.
    ADPGK-AS1 knockdown inhibited tumor growth in vivo
  • 50:34 56.
    ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
  • 50:35 57.
    ADPGK-AS1 overexpression in macrophages induced a tumor-promoting M2-like phenotype
  • 51:09 58.
    ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
  • 51:10 59.
    ADPGK-AS1 knockdown inhibited tumor growth in vivo
  • 57:37 60.
    ADPGK-AS1 knockdown inhibited tumor growth in vivo
  • 57:41 61.
    ADPGK-AS1 knockdown inhibited tumor growth in vivo
  • 58:29 62.
    ADPGK-AS1 knockdown inhibited tumor growth in vivo
  • 1:01:25 63.
    ADPGK-AS1 influenced human lung tumor progression ex vivo
  • 1:04:03 64.
    CircZFR modulated MYO1B splicing
  • 1:04:16 65.
    Slide 19
  • 1:06:32 66.
    Thank you for listening
  • 1:06:42 67.
    ** after 20240219 lab meeting_俐妤.pptx
  • Index
  • Notes
  • Comment
  • Fullscreen
20240219 lab meeting_俐妤
Duration: 1:06:51, Browse: 112, Last Updated: 2024-02-19
    • 00:00 1.
      index 1
    • 00:21 2.
      Metabolic heterogeneity in lung tumors
    • 01:08 3.
      LncRNA ADPGK-AS1 was upregulated in TAMs
    • 04:10 4.
      LncRNA ADPGK-AS1 was upregulated in TAMs in association with mitochondria
    • 04:12 5.
      LncRNA ADPGK-AS1 was upregulated in TAMs
    • 05:40 6.
      LncRNA ADPGK-AS1 was upregulated in TAMs in association with mitochondria
    • 11:50 7.
      MRPL35 was abundant in M2-like TAMs
    • 18:52 8.
      ADPGK-AS1 overexpression altered the regulation of mitochondrial metabolism
    • 23:32 9.
      ADPGK-AS1 overexpression altered the regulation of mitochondrial metabolism
    • 25:12 10.
      ADPGK-AS1 overexpression altered the regulation of mitochondrial metabolism
    • 25:13 11.
      ADPGK-AS1 overexpression increased levels of TCA cycle metabolites
    • 25:13 12.
      ADPGK-AS1 overexpression decreased ROS levels
    • 25:14 13.
      Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
    • 25:14 14.
      Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
    • 25:15 15.
      ADPGK-AS1 overexpression in macrophages induced a tumor-promoting M2-like phenotype
    • 25:15 16.
      ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
    • 25:16 17.
      ADPGK-AS1 knockdown inhibited tumor growth in vivo
    • 25:16 18.
      ADPGK-AS1 knockdown inhibited tumor growth in vivo
    • 25:16 19.
      ADPGK-AS1 influenced human lung tumor progression ex vivo
    • 25:17 20.
      CircZFR modulated MYO1B splicing
    • 25:17 21.
      Slide 19
    • 25:17 22.
      Thank you for listening
    • 25:18 23.
      RNA therapy
    • 25:18 24.
      Oxygen consumption rate (OCR)
    • 28:58 25.
      RNA therapy
    • 28:59 26.
      Thank you for listening
    • 28:59 27.
      Slide 19
    • 28:59 28.
      CircZFR modulated MYO1B splicing
    • 29:00 29.
      ADPGK-AS1 influenced human lung tumor progression ex vivo
    • 29:00 30.
      ADPGK-AS1 knockdown inhibited tumor growth in vivo
    • 29:01 31.
      ADPGK-AS1 knockdown inhibited tumor growth in vivo
    • 29:01 32.
      ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
    • 29:02 33.
      ADPGK-AS1 overexpression in macrophages induced a tumor-promoting M2-like phenotype
    • 29:03 34.
      Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
    • 29:03 35.
      Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
    • 29:04 36.
      ADPGK-AS1 overexpression decreased ROS levels
    • 29:05 37.
      ADPGK-AS1 overexpression increased levels of TCA cycle metabolites
    • 29:05 38.
      ADPGK-AS1 overexpression altered the regulation of mitochondrial metabolism
    • 29:06 39.
      ADPGK-AS1 overexpression altered the regulation of mitochondrial metabolism
    • 29:08 40.
      ADPGK-AS1 overexpression altered the regulation of mitochondrial metabolism
    • 30:20 41.
      ADPGK-AS1 overexpression increased levels of TCA cycle metabolites
    • 36:55 42.
      ADPGK-AS1 overexpression decreased ROS levels
    • 38:57 43.
      Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
    • 39:00 44.
      ADPGK-AS1 overexpression decreased ROS levels
    • 39:07 45.
      Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
    • 41:32 46.
      Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
    • 41:37 47.
      Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
    • 41:38 48.
      Macrophages upregulated ADPGK-AS1 and adapted their metabolic signaling pathways after crosstalk with tumor cells
    • 45:33 49.
      ADPGK-AS1 overexpression in macrophages induced a tumor-promoting M2-like phenotype
    • 49:03 50.
      ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
    • 50:11 51.
      ADPGK-AS1 knockdown inhibited tumor growth in vivo
    • 50:13 52.
      ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
    • 50:14 53.
      ADPGK-AS1 overexpression in macrophages induced a tumor-promoting M2-like phenotype
    • 50:33 54.
      ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
    • 50:33 55.
      ADPGK-AS1 knockdown inhibited tumor growth in vivo
    • 50:34 56.
      ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
    • 50:35 57.
      ADPGK-AS1 overexpression in macrophages induced a tumor-promoting M2-like phenotype
    • 51:09 58.
      ADPGK-AS1 knockdown in macrophages induced M1-like phenotype
    • 51:10 59.
      ADPGK-AS1 knockdown inhibited tumor growth in vivo
    • 57:37 60.
      ADPGK-AS1 knockdown inhibited tumor growth in vivo
    • 57:41 61.
      ADPGK-AS1 knockdown inhibited tumor growth in vivo
    • 58:29 62.
      ADPGK-AS1 knockdown inhibited tumor growth in vivo
    • 1:01:25 63.
      ADPGK-AS1 influenced human lung tumor progression ex vivo
    • 1:04:03 64.
      CircZFR modulated MYO1B splicing
    • 1:04:16 65.
      Slide 19
    • 1:06:32 66.
      Thank you for listening
    • 1:06:42 67.
      ** after 20240219 lab meeting_俐妤.pptx
    Location
    Folder name
    2024
    Author
    朱庭汶
    Branch
    賴亮全教授
    Created
    2024-02-19 10:22:21
    Last Updated
    2024-02-19 10:46:12
    Duration
    1:06:51