• 00:00 1.
    index 1
  • 00:21 2.
    Slide 2
  • 01:05 3.
    Slide 3
  • 01:57 4.
    CircRNA
  • 07:41 5.
    CircRNA and diseases
  • 08:03 6.
    gastric cancer
  • 08:59 7.
    hsa_circ_0069982 is selected from 12 DEcircRNAs in GC
  • 15:46 8.
    CircMTHFD2L is a downregulated circRNA with coding potential in GC
  • 16:49 9.
    hsa_circ_0069982 is selected from 12 DEcircRNAs in GC
  • 16:53 10.
    CircMTHFD2L is a downregulated circRNA with coding potential in GC
  • 33:43 11.
    CircMTHFD2L is more stable than linear, and located in cytoplasm
  • 40:40 12.
    circMTHFD2L binds to polysomes and be translated but not ATG mutant
  • 51:31 13.
    CM-248aa decrease expression in GC. and CM-248aa is verified in both endogenous or exogenous
  • 52:40 14.
    Low CM-248aa promotes overall survival in GC patients
  • 53:01 15.
    The subcellular localization of endogenous CM-248aawas distributed mainly in the nucleus by NLS
  • 53:02 16.
    Low CM-248aa promotes overall survival in GC patients
  • 55:04 17.
    The subcellular localization of endogenous CM-248aawas distributed mainly in the nucleus by NLS
  • 57:44 18.
    Low CM-248aa promotes overall survival in GC patients
  • 57:44 19.
    CM-248aa decrease expression in GC. and CM-248aa is verified in both endogenous or exogenous
  • 57:45 20.
    circMTHFD2L binds to polysomes and be translated but not ATG mutant
  • 58:02 21.
    CM-248aa decrease expression in GC. and CM-248aa is verified in both endogenous or exogenous
  • 58:03 22.
    Low CM-248aa promotes overall survival in GC patients
  • 58:03 23.
    The subcellular localization of endogenous CM-248aawas distributed mainly in the nucleus by NLS
  • 59:37 24.
    CM-248aa protein or mRNA expression is regulated by circMTHFD2L
  • 59:44 25.
    The subcellular localization of endogenous CM-248aawas distributed mainly in the nucleus by NLS
  • 1:04:29 26.
    CM-248aa protein or mRNA expression is regulated by circMTHFD2L
  • 1:08:12 27.
    GC progression is repressed by CM-248aa
  • 1:10:06 28.
    GC progression is repressed by CM-248aa
  • 1:11:04 29.
    GC progression is repressed by CM-248aa
  • 1:13:52 30.
    GC progression is repressed by CM-248aa
  • 1:14:16 31.
    GC progression is repressed by CM-248aa
  • 1:14:18 32.
    SET might potentially interact with CM-248aa
  • 1:14:19 33.
    GC progression is repressed by CM-248aa
  • 1:14:29 34.
    GC progression is repressed by CM-248aa
  • 1:15:24 35.
    GC progression is repressed by CM-248aa
  • 1:15:39 36.
    SET might potentially interact with CM-248aa
  • 1:18:29 37.
    CM-248aa inhibits phosphorylation of AKT, ERK, P65 by SET
  • 1:25:47 38.
    SET interacts with CM-248aa by salt bridge, inhibiting PP2Ac expression
  • 1:25:50 39.
    CM-248aa inhibits phosphorylation of AKT, ERK, P65 by SET
  • 1:26:30 40.
    SET interacts with CM-248aa by salt bridge, inhibiting PP2Ac expression
  • 1:37:54 41.
    CM-248aa represses GC growth in animal model
  • 1:38:17 42.
    CM-248aa inhibits p-AKT, p-ERK,p-P65 positive signal in IHC staining
  • 1:38:43 43.
    CM-248aa represses GC metastasis to lung in animal model
  • 1:40:07 44.
    Conclusion
  • 1:41:01 45.
    Pros
  • 1:41:56 46.
    Slide 28
  • 1:42:00 47.
    Pros
  • 1:42:00 48.
    Conclusion
  • Index
  • Notes
  • Comment
  • Fullscreen
20231225 lab meeting_楷軒
Duration: 1:42:16, Browse: 80, Last Updated: 2023-12-25
    • 00:00 1.
      index 1
    • 00:21 2.
      Slide 2
    • 01:05 3.
      Slide 3
    • 01:57 4.
      CircRNA
    • 07:41 5.
      CircRNA and diseases
    • 08:03 6.
      gastric cancer
    • 08:59 7.
      hsa_circ_0069982 is selected from 12 DEcircRNAs in GC
    • 15:46 8.
      CircMTHFD2L is a downregulated circRNA with coding potential in GC
    • 16:49 9.
      hsa_circ_0069982 is selected from 12 DEcircRNAs in GC
    • 16:53 10.
      CircMTHFD2L is a downregulated circRNA with coding potential in GC
    • 33:43 11.
      CircMTHFD2L is more stable than linear, and located in cytoplasm
    • 40:40 12.
      circMTHFD2L binds to polysomes and be translated but not ATG mutant
    • 51:31 13.
      CM-248aa decrease expression in GC. and CM-248aa is verified in both endogenous or exogenous
    • 52:40 14.
      Low CM-248aa promotes overall survival in GC patients
    • 53:01 15.
      The subcellular localization of endogenous CM-248aawas distributed mainly in the nucleus by NLS
    • 53:02 16.
      Low CM-248aa promotes overall survival in GC patients
    • 55:04 17.
      The subcellular localization of endogenous CM-248aawas distributed mainly in the nucleus by NLS
    • 57:44 18.
      Low CM-248aa promotes overall survival in GC patients
    • 57:44 19.
      CM-248aa decrease expression in GC. and CM-248aa is verified in both endogenous or exogenous
    • 57:45 20.
      circMTHFD2L binds to polysomes and be translated but not ATG mutant
    • 58:02 21.
      CM-248aa decrease expression in GC. and CM-248aa is verified in both endogenous or exogenous
    • 58:03 22.
      Low CM-248aa promotes overall survival in GC patients
    • 58:03 23.
      The subcellular localization of endogenous CM-248aawas distributed mainly in the nucleus by NLS
    • 59:37 24.
      CM-248aa protein or mRNA expression is regulated by circMTHFD2L
    • 59:44 25.
      The subcellular localization of endogenous CM-248aawas distributed mainly in the nucleus by NLS
    • 1:04:29 26.
      CM-248aa protein or mRNA expression is regulated by circMTHFD2L
    • 1:08:12 27.
      GC progression is repressed by CM-248aa
    • 1:10:06 28.
      GC progression is repressed by CM-248aa
    • 1:11:04 29.
      GC progression is repressed by CM-248aa
    • 1:13:52 30.
      GC progression is repressed by CM-248aa
    • 1:14:16 31.
      GC progression is repressed by CM-248aa
    • 1:14:18 32.
      SET might potentially interact with CM-248aa
    • 1:14:19 33.
      GC progression is repressed by CM-248aa
    • 1:14:29 34.
      GC progression is repressed by CM-248aa
    • 1:15:24 35.
      GC progression is repressed by CM-248aa
    • 1:15:39 36.
      SET might potentially interact with CM-248aa
    • 1:18:29 37.
      CM-248aa inhibits phosphorylation of AKT, ERK, P65 by SET
    • 1:25:47 38.
      SET interacts with CM-248aa by salt bridge, inhibiting PP2Ac expression
    • 1:25:50 39.
      CM-248aa inhibits phosphorylation of AKT, ERK, P65 by SET
    • 1:26:30 40.
      SET interacts with CM-248aa by salt bridge, inhibiting PP2Ac expression
    • 1:37:54 41.
      CM-248aa represses GC growth in animal model
    • 1:38:17 42.
      CM-248aa inhibits p-AKT, p-ERK,p-P65 positive signal in IHC staining
    • 1:38:43 43.
      CM-248aa represses GC metastasis to lung in animal model
    • 1:40:07 44.
      Conclusion
    • 1:41:01 45.
      Pros
    • 1:41:56 46.
      Slide 28
    • 1:42:00 47.
      Pros
    • 1:42:00 48.
      Conclusion
    Location
    Folder name
    2023
    Author
    周楷軒
    Branch
    賴亮全教授
    Created
    2023-12-25 11:56:23
    Last Updated
    2023-12-25 13:56:16
    Duration
    1:42:16