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00:00
1.
index 1
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00:21
2.
Slide 2
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01:05
3.
Slide 3
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01:57
4.
CircRNA
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07:41
5.
CircRNA and diseases
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08:03
6.
gastric cancer
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08:59
7.
hsa_circ_0069982 is selected from 12 DEcircRNAs in GC
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15:46
8.
CircMTHFD2L is a downregulated circRNA with coding potential in GC
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16:49
9.
hsa_circ_0069982 is selected from 12 DEcircRNAs in GC
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16:53
10.
CircMTHFD2L is a downregulated circRNA with coding potential in GC
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33:43
11.
CircMTHFD2L is more stable than linear, and located in cytoplasm
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40:40
12.
circMTHFD2L binds to polysomes and be translated but not ATG mutant
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51:31
13.
CM-248aa decrease expression in GC. and CM-248aa is verified in both endogenous or exogenous
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52:40
14.
Low CM-248aa promotes overall survival in GC patients
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53:01
15.
The subcellular localization of endogenous CM-248aawas distributed mainly in the nucleus by NLS
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53:02
16.
Low CM-248aa promotes overall survival in GC patients
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55:04
17.
The subcellular localization of endogenous CM-248aawas distributed mainly in the nucleus by NLS
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57:44
18.
Low CM-248aa promotes overall survival in GC patients
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57:44
19.
CM-248aa decrease expression in GC. and CM-248aa is verified in both endogenous or exogenous
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57:45
20.
circMTHFD2L binds to polysomes and be translated but not ATG mutant
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58:02
21.
CM-248aa decrease expression in GC. and CM-248aa is verified in both endogenous or exogenous
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58:03
22.
Low CM-248aa promotes overall survival in GC patients
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58:03
23.
The subcellular localization of endogenous CM-248aawas distributed mainly in the nucleus by NLS
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59:37
24.
CM-248aa protein or mRNA expression is regulated by circMTHFD2L
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59:44
25.
The subcellular localization of endogenous CM-248aawas distributed mainly in the nucleus by NLS
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1:04:29
26.
CM-248aa protein or mRNA expression is regulated by circMTHFD2L
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1:08:12
27.
GC progression is repressed by CM-248aa
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1:10:06
28.
GC progression is repressed by CM-248aa
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1:11:04
29.
GC progression is repressed by CM-248aa
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1:13:52
30.
GC progression is repressed by CM-248aa
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1:14:16
31.
GC progression is repressed by CM-248aa
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1:14:18
32.
SET might potentially interact with CM-248aa
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1:14:19
33.
GC progression is repressed by CM-248aa
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1:14:29
34.
GC progression is repressed by CM-248aa
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1:15:24
35.
GC progression is repressed by CM-248aa
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1:15:39
36.
SET might potentially interact with CM-248aa
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1:18:29
37.
CM-248aa inhibits phosphorylation of AKT, ERK, P65 by SET
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1:25:47
38.
SET interacts with CM-248aa by salt bridge, inhibiting PP2Ac expression
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1:25:50
39.
CM-248aa inhibits phosphorylation of AKT, ERK, P65 by SET
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1:26:30
40.
SET interacts with CM-248aa by salt bridge, inhibiting PP2Ac expression
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1:37:54
41.
CM-248aa represses GC growth in animal model
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1:38:17
42.
CM-248aa inhibits p-AKT, p-ERK,p-P65 positive signal in IHC staining
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1:38:43
43.
CM-248aa represses GC metastasis to lung in animal model
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1:40:07
44.
Conclusion
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1:41:01
45.
Pros
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1:41:56
46.
Slide 28
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1:42:00
47.
Pros
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1:42:00
48.
Conclusion