Decide Which Genes are Significantly Regulated ?

Decide Which Genes are Significantly Regulated ?

Decide Which Genes are Significantly Regulated ?

Statistical Distribution

Decide Which Genes are Significantly Regulated ?

Question

Decide which genes are significantly regulated ?3

Permutation test

QuestionWhat is F-test? Mann–Whitney tests Kruskal–Wallis tests Analysis of Variance Permutation test

Concept of Biostatistics About Nominal (Categorical) Variable

Concept of Biostatistics About Nominal Variable

Survival Analysis

Univariate Method: Kaplan-Meier Survival Curves

Web Tool: Kaplan-Meier Plotter

Multivariate Method: Cox Proportional Hazards

Summary

Clustering Analysis

Distances Between Clusters Used For Hierarchical Clustering

Algorithm: deterministic (top-down: divisive; bottom-up: agglomerative) Compute distance matrix for all pairs of nodes (genes); Find two closest nodes Merge them into a new node with some joining method Compute distance of new node to all other nodes Rep

Hierarchical Clustering1

Hierarchical Clustering2

Partitional Algorithms: K-means / K-medians

Partitional Algorithms: K-means / K-medians

Partitional Algorithms: Self-Organizing Map Algorithm

Artificial Neural Network

The SOM Algorithm - A Summary of Steps1

The SOM Algorithm - A Summary of Steps2

The SOM Algorithm - A Summary of Steps3

The SOM Algorithm - A Summary of Steps5

Supervised Algorithm

Support Vector Machine

K-Nearest Neighbor (K-NN)

Decision Trees / Random Forest